Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…Methods This study is a prospective, multicenter, randomized controlled clinical trial involving patients with pleural infections. …”
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Effects of aquatic exercise compared with land-based exercise on the body composition and function of older adults with sarcopenia: protocol for a randomised controlled trial by Na Li, Fang Cheng, Jinfeng Yang, Yuanpeng Liao, PeiJie Sun, Weicheng Yang, Jinqi Yang, Jianxin Ran

“…This study has been registered with the Chinese Clinical Trial Registry (ChiCTR2300077457). All participants will provide written informed consent.Trial registration number Chinese Clinical Trial Registry ChiCTR2300077457.…”
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CIMAvax-EGF®, new therapeutic alternative for lung cancer: its application in Cienfuegos by Yoana Herrera Leiva, Teresita Sabatés Llerandi

“…In 2016, the EGF-Predictor Phase IV Clinical Trial Opening Workshop was held in Cienfuegos, sponsored by the Center for Molecular Immunology of Havana which coexist with other clinical trials. …”
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Reassessing the Role for Lamivudine in Chronic Hepatitis B Infection: A Four-Year Cohort Analysis by Tahir Shaikh, Curtis Cooper

“…The data supporting the use of antiviral agents other than lamivudine in the management of patients with hepatitis B virus (HBV) infection are based on highly selected clinical trial populations that may not be representative of typical HBV-infected populations encountered in many clinics. …”
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Żywienie a prewencja chorób układu krążenia by Grażyna Nowicka

“…Recent epidemiological and clinical trial data provide evidence of the great effectiveness of dietary interventions in cardiovascular disease prevention and treatment. …”
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Association of delayed asthma diagnosis with asthma exacerbations in children by Chung-Il Wi, MD, Euijung Ryu, PhD, Katherine S. King, MS, Jung Hyun Kwon, MD, PhD, Joshua T. Bublitz, BS, Miguel Park, MD, Sergio E. Chiarella, MD, Jason D. Greenwood, MD, MS, Thanai Pongdee, MD, Lynnea Myers, PhD, Björn Nordlund, PhD, Sunghwan Sohn, PhD, Elham Sagheb, MS, Bhavani Singh Agnikula Kshatriya, MS, Dave Watson, PhD, Hongfang Liu, PhD, Beverley J. Sheares, MD, MS, Carla M. Davis, MD, Wade Schulz, MD, PhD, Young J. Juhn, MD, MPH

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An Objective Pain Score for Chronic Pain Clinic Patients by Agnes K. Pace, Melanio Bruceta, John Donovan, Sonia J. Vaida, Jill M. Eckert

“…This study was registered with ClinicalTrial.gov with National Clinical Trial Number NCT02882971.…”
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Impact of a synchronous prophylactic treatment of the anterior accessory saphenous vein on the recurrent varicose vein rate in patients undergoing thermal ablation of an insufficie... by Lorenz Uhlmann, Christine Fink, Karsten Hartmann, Thomas Mattausch, Hans-Christian Wenzel, Phillip Zollmann, Jürgen Veltman, Thomas Weiler, Guido Lengfellner, Lars Müller, Markus Stücker, Felizitas Pannier, Carmen Dietrich, Tobias Hirsch

“…This study was prospectively registered at the German Clinical Trial Register (https://www.germanctr.de/). Research findings will be disseminated in a peer-reviewed journal and at relevant conferences.Trial registration number German Clinical Trial Registry (DRKS00015486).…”
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The Effect of Counseling Based on Functional Analytic Psychotherapy with Enhanced Cognitive Therapy on Married Adolescent Women’s Sexual Self-efficacy: A Prospective Study by Maryam Gholami, Katayoun Alidousti, Mozhgan Taebi, Yunes Jahani, Atefeh Ahmadi

“…Methods: This prospective clinical trial, conducted in 2019, used a pre-test/post-test design with a control group. …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…Written informed consent was obtained from all participants.Clinical trial registrationhttps://clinicaltrials.gov/, identifier, ChiCTR2200061859.…”
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Dentoskeletal effects of aesthetic and conventional twin block appliances in the treatment of skeletal class II malocclusion: a randomized controlled trial by Mohamed Najati Alsilq, Mohamed Youssef

“…A two-arm parallel group randomized clinical trial was performed at the Department of Orthodontics, University of Damascus, Syria. …”
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Digestive bleeding in children by Ana Barbarita Navarro Sombert, Graciela Goire Herrera, Ledicel Nilo Gámez Fonts, Luis Antonio García Rodríguez

“…The most serious bleedings are secondary to esophageal varices and Meckel's diverticulum. A good clinical trial, supported by image and endoscopic tests, and standardized therapy, are the key elements for the reduction of mortality in these patients. …”
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Therapeutic landscape for inherited ocular diseases: current and emerging therapies by Hwei Wuen Chan, Jaslyn Oh, Bart Leroy

“…This review discusses the fundamentals underlying the mode of inheritance, natural history studies and clinical trial outcomes, as well as current and emerging therapies covering gene therapy strategies, cell-based therapies and bionic vision.…”
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The Pain and Sleep Questionnaire Three-Item Index (PSQ-3): A Reliable and Valid Measure of The Impact of Pain on Sleep in Chronic Nonmalignant Pain of Various Etiologies by Lindsay E Ayearst, Zoltan Harsanyi, Kenneth J Michalko

“…Because pain-related sleep disturbance may serve as a marker for the assessment of responses to treatment for chronic pain, inclusion of a measure designed to assess the impact of pain on sleep in clinical trial protocols is important, if not necessary. …”
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Efficacy and Safety Concerns with Sn-Mesoporphyrin as an Adjunct Therapy in Neonatal Hyperbilirubinemia: A Literature Review by Prakar Poudel, Sudhir Adhikari

“…This review evaluates in-vitro studies, animal studies, and clinical trials for the efficacy and safety of tin analogues of metalloporphyrin. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…By enhancing CCR, healthcare teams can improve patient outcomes and ensure safer healthcare delivery. Clinical trial number Not required, as this is not a clinical trial and does not involve any healthcare interventions with human participants.…”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by Ana Izabela Sobral de Oliveira-Souza, Jordana Barbosa-Silva, Douglas P. Gross, Bruno R. da Costa, Nikolaus Ballenberger, Tiago V. Pereira, Liz Dennett, Susan Armijo-Olivo

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Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis by Ryoji Ichijima, Hisatomo Ikehara, Tomomi Sugita, Daisuke Yamaguchi, Yasuhiko Nagata, Kanako Ogura, Mitsuru Esaki, Yosuke Minoda, Hiroyuki Ono, Yuki Maeda, Shinsuke Kiriyama, Tetsuya Sumiyoshi, Yuichi Kanmura

“…ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two groups were matched using propensity score matching. …”
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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Continued efforts to understand how people with HIV experience ATIs will improve future designs of HIV cure clinical trials.…”
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