The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Iranian overweight and obese elderly: a randomized, double-blind, placebo-controlled clinical trial by Mehran Noori, Zainab Shateri, Siavash Babajafari, Mohammad Hadi Eskandari, Karim Parastouei, Mohammad Ghasemi, Hoseein Afshari, Mohammad Samadi

“…Methods This study was a double-blind, randomized, and placebo-controlled clinical trial conducted on 67 elderly men aged over 65, who were randomly divided into two groups. …”
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β-hydroxy-β-methylbutyrate-enriched nutritional supplements for obese adults during weight loss: study protocol of a randomised, double-blind, placebo-controlled clinical trial by Ming Yang, Xiaofan Jing, Yuxiang Liang, Renjie Wang, Hongbo Fu, Jiaojiao Jiang

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Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol. by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

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Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator randomised clinical trial by Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts

“…The objective of this study was to determine if a targeted, digital health intervention changed patient risk behaviour, increased naloxone uptake and increased knowledge about opioid overdose prevention and naloxone.Methods We conducted a pragmatic randomised clinical trial among patients prescribed LTOT in a healthcare delivery system in Colorado. …”
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Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

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Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial by Mahin Bakhshi, Shahzad Gholami, Arash Mahboubi, Mahmoud Reza Jaafari, Mahshid Namdari

“…This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. …”
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A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty liver disease by Sara Mighani, Rasoul Samimi, Mohamadreza Rashidi Nooshabadi, Seyed Amir Farzam, Hossein Khadem Haghighian, Maryam Javadi

“…Trial registration This study was prospectively registered at the Iranian Registry of Clinical Trials on the 23th of January 2022 (ID: IRCT20141025019669N21).…”
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Response to: Comment on “Effects of a Pragmatic Home-Based Exercise Program Concurrent With Neoadjuvant Therapy on Physical Function of Patients With Pancreatic Cancer: The PancFit Randomized Clinical Trial” by An T. Ngo-Huang, DO, Nathan H. Parker, PhD, Keri L. Schadler, PhD, Matthew H. G. Katz, MD

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Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers by John Metzcar, Rachael Guenter, Yafei Wang, Kimberly M Baker, Kate E Lines

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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

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The Effect of Breathing Exercise Using Bubble Blower on Anxiety and Pain during Inferior Alveolar Nerve Block in Children Aged 7 to 10 Years: A Crossover Randomized Clinical Trial by Zahra Bahrololoomi, Tahereh Sadeghiyeh, Maedeh Rezaei, Nahid Maghsoudi

“…In this randomized crossover clinical trial, thirty-five children with moderate to severe anxiety requiring bilateral pulp therapy of mandibular primary molars were enrolled. …”
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A comparative study between central quadrantectomy and nipple resection with areola preservation Versus Grisotti flap mammoplasty in central breast lesions extending to nipple: a randomized clinical trial by Philobater Bahgat Adly Awad, Basma Hussein Abdelaziz Hassan, Abanoub Adel Shafek Awad, Abdelrahman Ahmed Younis Mohamed Attaia, Kerolos Bahgat Adly Awad, Dina Mohamed Hanafy, Ahmed Gamal El Din Osman

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Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a randomized clinical trial by Larissa dos Santos Leonel, Ingrid Alessandra Victoria Wolin, Angélica Danielevicz, Mabel Diesel, Marina Isolde Constantini, João Batista de Oliveira Junior, Allana Andrade Souza, Thaís Reichert, João Gabriel Silveira-Rodrigues, Danusa Dias Soares, Marcelo Fernando Ronsoni, Simone Van De Sande Lee, Alex Rafacho, Guilherme Fleury Fina Speretta, Karla Siqueira Lottermann, Josefina Bertoli, Alexandre Pastoris Muller, Aline Mendes Gerage, Cíntia de La Rocha Freitas, Rodrigo Sudatti Delevatti

“…Trial registration Brazilian Clinical Trial Registry (ReBEC) RBR-10fwqmfy. Registered on April 16, 2024.…”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, multi-site clinical trial by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…This trial was registered with ClinicalTrials.gov (NCT04709952). Results In the tDCS study, of 141 participants (102 [72.3%] women; mean age 35.7 years, standard deviation 12.7), 95 completed the trial. …”
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A Commentary on “Effect of Acupuncture Intervention on Chronic Musculoskeletal Pain in Hemodialysis-Dependent Kidney Failure Patients: Study Protocol for a Randomized Controlled Clinical Trial” [Letter] by Li S, Kong D, Gao H

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A comparison of the efficacy of the effect of online versus face-to-face group counseling based on positive-approach on sexual intimacy of women after benign abdominal hysterectomy: a clinical trial by Orly Nazanin Kalimi, Tayebeh Mokhtari Sorkhani, Ali Dehghani, Mahshid Bokaie

“…Iranian Registry of Clinical Trials - IRCT20230209057373N1…”
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Investigating the impact of couple counseling based on the CHARMS model on sexual quality of life and marital satisfaction of wives of men suffering from myocardial infarction: a randomized clinical trial study by Delniya Ghafuri, Soheila Rabeipoor, Kamal Khademvatani, Samira Barjasteh, Atefeh Yas

“…Method This two-group randomized clinical trial study with a parallel design was conducted in 2024 in Urmia, Iran. …”
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Representativeness of the dabigatran, apixaban and rivaroxaban clinical trial populations to real-world atrial fibrillation patients in the United Kingdom: a cross-sectional analysis using the General Practice Research Database by Gregory Y H Lip, Sally Lee, Brigitta U Monz, Andreas Clemens, Martina Brueckmann

“…Differences between trials should be taken into account when considering the applicability of findings from randomised clinical trials. However, assessing representativeness is not a substitute for assessing generalisibility, that is, how well clinical trial results would translate into effectiveness and safety in everyday routine care.…”
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One-stage versus two-stage video-assisted thoracic surgery for synchronous bilateral pulmonary nodules: protocol for a single center, non-randomized clinical trial (OTVATS-1) by Yu Han, Weixun Zhang, Peihang Xu, Zhoujunyi Tian, Yang Hao, Jin Zhang, Tai Ren, Chaoyang Liang

“…It has been officially registered with the China Clinical Trial Registry, TRN: ChiCTR2300071198 and registration date is May. 8, 2023.…”
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Evaluation of Comparative Efficacy of Ashwagandha (Withania somnifera) vs Brahmi (Bacopa monnieri Linn) on Stress Level and Quality of Sleep in the Subjects Experiencing Mental Stress: A Clinical Trial Protocol by Mohnish Vijay Gokhale, Vaishali Kuchewar, Pankaj Yadav, Bhishmani Tarare

“…Materials and Methods: It is a double-blind standard control clinical trial and the study will be undertaken at Department of Kayachikitsa, Mahatma Gandhi Ayurved Hospital and Research Centre (MGACHRC) at Salod (H), Wardha, Maharashtra, India starting from January 2024 to June 2025. …”
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