Analgesic Efficacy of Intravenous Ibuprofen in the Treatment of Postoperative Acute Pain: A Phase III Multicenter Randomized Placebo-ControlledDouble-Blind Clinical Trial by Hong-Su Zhou, Ting-Ting Li, Yu Pi, Ting-Hua Wang, Fei Liu, Liu-Lin Xiong

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Long-term efficacy and safety of alemtuzumab in participants with highly active MS: TOPAZ clinical trial and interim analysis of TREAT-MS real-world study by Tjalf Ziemssen, Ann D. Bass, Bart Van Wijmeersch, Sara Eichau, Stephan Richter, Frank Hoffmann, Nicole M. Armstrong, Magdalena Chirieac, Janete Cunha-Santos, Barry A. Singer

“…Sustained efficacy up to 9 years was observed in the phase IIIb/IV open-label TOPAZ clinical trial and assessed in the real-world retrospective and prospective study, TREAT-MS. …”
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Human-Prosthetic Interaction (HumanIT): A study protocol for a clinical trial evaluating brain neuroplasticity and functional performance after lower limb loss. by Elke Lathouwers, Bruno Tassignon, Alexandre Maricot, Ahmed Radwan, Maarten Naeyaert, Hubert Raeymaekers, Peter Van Schuerbeek, Stefan Sunaert, Johan De Mey, Kevin De Pauw, Kevin De Pauw

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Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial by Thanapon Chobpenthai, Patcharapol Arunwatthanangkul, Wiriya Mahikul

“…Patients with moderate to severe (grades 3-4) OA by the Kellgren and Lawrence grading system with a poor to good Oxford Knee Score were selected for enrollment in this clinical trial. The participants were divided into three intervention groups: the cooling gel pad group for 20 minutes duration once a day (n = 20), the diclofenac gel group for 4 times a day (n = 20) as the control group (total n = 40), and the cabbage leaf group for 1-hour duration once a day (n = 20) as the experimental group (total n = 20). …”
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Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinical trial. by Si-Jing Chen, Jian-Yu Que, Ngan Yin Chan, Le Shi, Shirley Xin Li, Joey Wing Yan Chan, Weizhen Huang, Chris Xie Chen, Chi Ching Tsang, Yuen Lam Ho, Charles M Morin, Ji-Hui Zhang, Lin Lu, Yun Kwok Wing

“…<h4>Trial registration</h4>ClinicalTrials.Gov (NCT04069247).…”
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Comparison of Adequacy of Anaesthesia (AoA) monitors with CONOX® monitor regarding sevoflurane consumption during routine general anaesthesia: A randomised clinical trial by Rajendran. Arulkumaran, Anusha Cherian, Aswini Kuberan, Prasanna Udupi Bidkar

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A Pragmatic Clinical Trial to Compare the Real-World Effectiveness of V-Go versus Standard Delivery of Insulin in Patients with Advanced Type 2 Diabetes by Mark J. Cziraky, Scott Abbott, Matt Nguyen, Kay Larholt, Elizabeth Apgar, Thomas Wasser, Poul Strange, Leon Shi, H. Courtenay Harrison, Beverly Everitt, Lynn Nowak

“…**Objective:** This prospective pragmatic clinical trial evaluated V-Go, a wearable insulin delivery device, compared with standard treatment optimization (STO) among insulin-treated patients with T2DM in a realworld, community-based practice setting. …”
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The Effect of Vitamin D Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis of Clinical Trials by Maryam Afraie, Pourya Bahrami, Parisa Kohnepoushi, Sorour Khateri, Lobat Majidi, Lotfollah Saed, Kamran Zamani, Hedyeh Mohammadi Baharm, Yousef Moradi, Farhad Moradpour

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Efficacy of Virtual Reality Distraction in Reduction of Pain and Anxiety of Pediatric Dental Patients in an Iranian Population: A Split-Mouth Randomized Crossover Clinical Trial by Zahra Bahrololoomi, Javad Zein Al-Din, Nahid Maghsoudi, Samira Sajedi

“…Materials and Methods. This crossover clinical trial was conducted with eligible 6–8-year-old children requiring bilateral mandibular molar pulpotomy. …”
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Feasibility, safety and tolerability of estrogen and/or probiotics for improving vaginal health in Canadian African, Caribbean, and Black women: A pilot phase 1 clinical trial. by Biban Gill, Jocelyn M Wessels, Christina L Hayes, Jenna Ratcliffe, Junic Wokuri, Elizabeth Ball, Gregor Reid, Rupert Kaul, Jesleen Rana, Muna Alkhaifi, Wangari Tharao, Fiona Smaill, Charu Kaushic

“…<h4>Trial registration</h4>The trial was registered with Clinicaltrials.gov (NCT03837015) and CIHR HIV Clinical Trials (CTN308).…”
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Antimicrobial Efficacy of Intracanal Medicaments against E. Faecalis Bacteria in Infected Primary Molars by Using Real-Time PCR: A Randomized Clinical Trial by Yasamin Ghahramani, Najmeh Mohammadi, Ahmad Gholami, Dordaneh Ghaffaripour

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Chest-to-Back Skin-to-Skin Contact to Regulate Body Temperature for Low Birth Weight and/or Premature Babies: A Crossover Randomized Controlled Clinical Trial by Sisay Gere, Yemane Berhane, Alemayehu Worku

“…We applied a noninferiority clinical trial among LBW and/or premature infants admitted to a referral hospital neonatal intensive care unit (NICU) in Ethiopia. …”
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Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical trial protocol by Eliete Bouskela, Gabriela Andrade Paz, Marcus VDS Rangel, Caio Luan Farias, André Luiz Conveniente Soares, Erica Langner, Tatiana Teixeira, Patrícia M L Dutra, Paulo Farinatti, Maria das Graças C Souza, Juliana P Borges

“…This study was approved by the Ethics Committee of Pedro Ernesto University Hospital (CAAE 81718324.3.0000.5259) and registered on ClinicalTrials.gov (NCT06579807). Dissemination of the findings will include peer-reviewed publications, conference presentations and media releases.…”
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Comparison of the Effect of Enteral Feeding through the Bolus and Continuous Methods on Serum Phosphorus and Glucose Levels in Patients with Mechanical Ventilation: A Randomized Clinical Trial by Javad Seyyedi, Zahra Rooddehghan, Mostafa Mohammadi, Shima Haghani

“…Methods. In this clinical trial study, 34 patients in the intensive care unit of Imam Khomeini Hospital affiliated to the Tehran University of Medical Sciences satisfied inclusion criteria and were randomly divided into control and intervention groups. …”
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Effects of whole-body vibration training on lower limb motor function and neural plasticity in patients with stroke: protocol for a randomised controlled clinical trial by Mingkai Zhang, Jianing Wei, Xueping Wu

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Efficacy and Safety of Dapagliflozin versus Liraglutide in Patients with Overweight or Obesity and Type 2 Diabetes Mellitus: A Randomised Controlled Clinical Trial in Tianjin, China by Hao Zhaohu, Huang Xiao, Shao Hailin, He Feng

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Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinical Trial by Muhittin CALIM, Serdar YESILTAS, Mustafa GUNAY, Ismail SUMER, Sedat AKBAS

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Randomized Clinical Trial of Intraocular Pressure-Lowering Medications on Preventing Spikes in Intraocular Pressure Following Intravitreal Anti-Vascular Endothelial Growth Factor Injections by Piriya Soomsawasdi, Kulawan Rojananuangnit, Eakkachai Arayangkoon, Ratchada Chantiwas, Sureeporn Pengrungreungwong, Nontakorn Preawsampran, Natnaree Tinpowong, Rujira Samakhararaksakul, Kanokwan Katkingkaew, Natthapuch Seekhum, Wanwisa Sathim

“…Methods This randomized double-blind clinical trial included one eye of each participant indicated for treatment with intravitreal injection of anti-VEGF agents (bevacizumab, aflibercept, and ranibizumab) and randomly allocated to one of the three prophylactic anti-glaucoma medications, with each drug further divided into one- and two-drop regimens before intravitreal injection. …”
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Feasibility, safety and tolerability of estrogen and/or probiotics for improving vaginal health in Canadian African, Caribbean, and Black women: A pilot phase 1 clinical trial by Biban Gill, Jocelyn M. Wessels, Christina L. Hayes, Jenna Ratcliffe, Junic Wokuri, Elizabeth Ball, Gregor Reid, Rupert Kaul, Jesleen Rana, Muna Alkhaifi, Wangari Tharao, Fiona Smaill, Charu Kaushic

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Effect of folic acid supplementation on diminished ovarian reserve: study protocol of a single-centre, open-label, randomised, placebo-controlled clinical trial by Yan Wang, Ling Zheng, Kaijun Liao, Dongli Lu, Jiaxin Wu, Binjin Wu, Zhaochun Wu, Zhenghua Jiang

“…The results of this clinical trial will be presented at scientific conferences and submitted to a peer-reviewed journal.Trial registration number Chinese Clinical Trial Registry, ChiCTR2100047410.…”
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