Journey of medical device development from the bench to the bedside—four real-life examples of commercial biomaterials development by Yves Bayon, Christophe Bureau, Maria J N Perreira, François Aubert, Michel Caillibotte, Robert Vestberg, Didier Letourneur

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The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical developmentBiomarke... by Morten Asser Karsdal, Lucio C. Rovati, Jeyanesh Tambiah, Olga Kubassova, Christoph Ladel, Francis Berenbaum, Anne-Christine Bay-Jensen, Lachy Mclean, Richard Loeser, Ali Mobasheri, Virginia B. Kraus

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REGULATORY STRATEGY OF CLINICAL DEVELOPMENT FOR FIXED COMBINATION MEDICINAL PRODUCTS by K. A. Yatsenko, V. S. Berezina

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Developer and Partnership Differences in COVID-19 and Other Infections: Insights from DNA Vaccines by Ryo Okuyama

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Optimizing development of anti-TNFα biosimilars based on 10 years’ experience by Cecil Nick

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Thrombopoietin Receptor Agonists: Clinical Use and Evaluation of Treatment Efficacy by A. G. Solodovnikov, E. Yu. Sorokina, E. I. Morkovin

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Healthy participant engagement in early clinical trials: results from the European EUFEMED survey by J. Klein, T. van Iersel, D. de Vries, Y. Donazzolo, I. Klingmann

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Unlocking cancer vaccine potential: What are the key factors? by Michael Grant, Lian Ni Lee, Senthil Chinnakannan, Orion Tong, Jonathan Kwok, Nicole Cianci, Luke Tillman, Abhishek Saha, Vinnycius Pereira Almeida, Carol Leung

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Deuteration may reduce the efficacy of dextromethorphan in treating agitation in Alzheimer’s disease by Anton Bespalov, Jina Swartz, Nadine Knowles, Hans J. Moebius

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Recommendations for the Clinical Development of Medicinal Products for Non-specific Influenza Chemoprophylaxis by A. I. Gubenko, O. Yu. Ivanova

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Integrating artificial intelligence in drug discovery and early drug development: a transformative approach by Alberto Ocana, Atanasio Pandiella, Cristian Privat, Iván Bravo, Miguel Luengo-Oroz, Eitan Amir, Balazs Gyorffy

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Approaches to clinical development of combination medicines in the Russian Federation and the Eurasian Economic Union in view of the requirements of the current legislation by A. V. Dobrovolskiy

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Important tool in our rare disease toolbox: hybrid retrospective-prospective natural history studies serve well as external comparators for rare disease studies by Chinenye Ugoji, Julien Heidt, Joan Largent, Emily Bratton, Laura Hester, Sareh Keshavarzi, Stuart Turner, Christina Mack

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Accelerated therapeutic development during COVID-19: insights, regulatory strategies, and recommendations for future pandemic preparedness by Miyuki Katayama, Mayumi Shikano

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