Current Enzooticity of <i>Dirofilaria immitis</i> and <i>Angiostrongylus vasorum</i> in Central and Southern Italy by Donato Traversa, Simone Morelli, Angela Di Cesare, Chiara Astuti, Alessandra Barlaam, Mariasole Colombo, Fabrizia Veronesi, Barbara Paoletti, Raffaella Iorio, Raffaella Maggi, Alessandra Passarelli, Alessia Pede, Linda Rossi, Manuela Diaferia

“…Many environmental and phenological changes have recently modified their geographic patterns in many countries; thus, this study has updated the distribution of <i>D. immitis</i> and <i>A. vasorum</i> in dog populations of selected regions of Central and Southern Italy. …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…RNA-seq was utilized to profile gene expression changes of ROD. We elucidated the functions of differentially expressed genes (DEGs) using gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and gene set enrichment analysis (GSEA). …”
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Evaluation of guided reporting: quality and reading time of automatically generated radiology report in breast magnetic resonance imaging using a dedicated software solution by Martin H. Maurer, Daniel Lorenz, Maximilian Clemens Otterbach, Igor Toker, Alexander Huppertz

“…Between FT and GR, 41 patient reports revealed no content differences, 33 revealed minor differences, and 6 revealed major differences that resulted in changes in treatment. The errors in all patient reports with major content differences were categorized as content omission errors caused by improper software operation (n = 2) or by missing content in software v. 0.8 displayable with v. 1.7 (n = 4). …”
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plaTform fOr Urinary tract infection diagnostiC evAluatioN (TOUCAN): a protocol for a prospective diagnostic accuracy study of point-of-care testing in patients suspected of acute... by Thomas R Fanshawe, Philip J Turner, Gail N Hayward, Margaret Glogowska, Alastair D Hay, Michael Moore, Mark Lown, Christopher C Butler, Mandy Wootton, Mark H Wilcox, Jane Freeman, Nicola Kenealy, Valerie Tate, Owain Llion, Rebecca Lowe

“…Secondary outcomes will include the symptom profile of patients presenting with uncomplicated UTI, a theoretical determination of how use of POCT results might change prescribing, an understanding of POCT failure rate and qualitative capture of the experiences of those using the POCT to deliver the study in primary care clinics.Ethics and dissemination Ethical approval was received from the London Central Research Ethics Committee (23/LO/0371) and the UK Health Research Authority. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…While much of the previous research has focused on transcriptional changes, this study examines translational alterations, specifically the role of cytoplasmic polyadenylation element binding protein 4 (CPEB4), a key regulator of translation. …”
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Age dependent deficits in speech recognition in quiet and noise are reflected in MGB activity and cochlear onset coding by Konrad Dapper, Stephan M. Wolpert, Jakob Schirmer, Stefan Fink, Etienne Gaudrain, Deniz Başkent, Wibke Singer, Sarah Verhulst, Christoph Braun, Ernst Dalhoff, Lukas Rüttiger, Matthias H.J. Munk, Marlies Knipper

“…In addition, increased phoneme-evoked EEG delay could be correlated with elevated extended high-frequency threshold (EHF) for phoneme changes that relied on TFS and TENV coding. This may suggest a role of pure-tone threshold averages (PTA) of EHF for TENV and TFS beyond sound localization that is reflected in likely MGB delays. …”
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Unravelling population structure and marker trait association using SSR markers among the identified drought tolerant rice landraces (Oryza sativa L.) by Shanmugam Manju Devi, John Amalraj Joel, Muthurajan Raveendran, Ramamoorthy Pushpam, Sengalan Muthuramu, Raman Pushpa, N. Sritharan, Periyasamy Prasanna, Ramalingam Suresh

“…With climate change, plants face numerous stresses, notably drought for rice cultivation. …”
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Effects of external ankle support on balance control outcomes following muscle fatigue in individuals with ankle instability: A systematic review and meta-analysis by Hanieh KHALILIYAN, Mahmood BAHRAMIZADEH, Amirhossein ZARE, Kavita BATRA, Gabriella NUCERA, Aldo SITIBONDO, Aanuoluwapo AFOLABI, Majid ANSARI, Olayinka ILESANMI, Lukasz SZARPAK, Alireza KHAGHANI, Shahla MOHAJERI, Farhad GHAFFARI, Arash SHARAFATVAZIRI

“…The meta-analysis results indicate that compared to the control group, external ankle supports after muscle fatigue significantly change Y balance clinical test-posterolateral [MD=1.22, 95% CI (0.16, 2.28), p=0.03], Y balance clinical test-posteromedial [Mean difference=2.60, 95% CI (0.42, 4.79), p=0.03], center of pressure time to stabilization-mediolateral [Mean difference=-0.68, 95% CI (-1.29, -0.07), p=0.04], center of pressure time to stabilization-vertical [Mean difference=-0.62, 95% CI (-0.94, -0.30), p=0.01], and vertical ground reaction force [Mean difference=0.58, 95% CI (0.21, 0.96), p=0.02]. …”
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The effectiveness of convalescent plasma administered on the first day of admission for COVID-19 patients: an open-label randomized controlled trial by Saeed Mohammadi, Mandana Pouladzadeh, Hamidreza Kouhpayeh, Shamsi Okati, Mehdi Safdarian, Peyman Eshghi, Parastoo Moradi Choghakabodi, Shahabeddin Mashaei, Sharareh Sanei Sistani, Yalda Khani, Soheila Nasizadeh, Ahmad Reza Shamshiri, Amir Teimourpour, Haijuan Wang

“…No significant differences were observed between the groups in terms of age (P = 0.119), sex (P = 0.418), comorbidities (P > 0.05), or pre- and post-treatment changes in temperature, lymphocyte count, erythrocyte sedimentation rate, or platelet count (all P > 0.05). …”
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Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo by Enrique Morales, Iñigo Rúa-Figueroa, José Luis Callejas Rubio, Ana Ávila Bernabéu, Ricardo Blanco Alonso, Maria C. Cid Xutgla, Gema Fernández Juárez, Natalia Mena-Vázquez, Juan José Ríos Blanco, Joaquín Manrique Escola, F. Javier Narváez García, Bernardo Sopeña, Luis F. Quintana Porras, Susana Romero-Yuste, Roser Solans Laqué

“…Current treatment has changed ANCA-associated vasculitis into a condition with a significant response rate, although with a not negligible relapse occurrence and cumulative organ lesions, mostly due to drug-related toxicities. …”
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Renin–angiotensin–aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study by Katharina Krenn, Felix Kraft, Luana Mandroiu, Verena Tretter, Roman Reindl-Schwaighofer, Theresa Clement, Oliver Domenig, Matthias G. Vossen, Gregor Riemann, Marko Poglitsch, Roman Ullrich

“…It is still unclear whether changes in the RAS are associated with prognosis of severe COVID-19. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…We found that transfection of LMH cells with miR124a-3p inhibitor alleviated the changes in GR and metabolic detoxification enzyme gene expression induced by AFB1. …”
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Acaricidal and insecticidal activities of entomopathogenic nematodes combined with rosemary essential oil and bacterium-synthesized silver nanoparticles against camel tick, Hyalomm... by Bander Albogami, Hadeer Darwish, Akram Alghamdi, Ahmed BahaaEldin Darwish, Wafa Mohammed Al-Otaibi, Mohamed A. Osman, Zamzam M. Al Dhafar, Abeer Mousa Alkhaibari, Abadi M. Mashlawi, Fadi Baakdah, Ahmed Noureldeen

“…Visual observation showed a color change from yellow to dark brown for AgNPs biosynthesized from P. mirabilis; the transmission electron microscopy (TEM) image and ultraviolet–visible (UV-Vis) spectrum showed well-dispersed particles with a diameter of 5–45 nm; and the greatest surface plasmon peaked at 320 nm. …”
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Spatiotemporal analysis of Plasmodium falciparum erythrocyte binding antigen-175 gene dimorphism in Ghana by Abraham Y. Kpirikai, Belinda A. Ofosu, Josie N. A. Okai, Victor Kornu, Abdul Rashid Kassim, Esther Donkor, Frederica Malm, Osumanu Ahmed, Mona-Liza E. Sakyi, Samirah Saiid, Albert Yao Kudakpo, Charles Mensah, Francis Dzabeng, Collins Morang’a, Gordon A. Awandare, Yaw Aniweh, Lucas N. Amenga-Etego

“…Between 2019 and 2022, the prevalence of the alleles changed significantly (χ2 = 6.5427, p = 0.03). Geometric mean parasite density for the C, F, and F/C alleles were 21,477.1 [95%CI 15,749.2 − 29,288.1], 18,308.0 [95%CI 15,149.9–22,124.5] and 22,690.4[95% CI 16,891.9–30,479.2], respectively. …”
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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…The soybean pot experiment was used to investigate the growth-promoting effects of cold-tolerant strains applied to soybeans and to analyze the effects of changes in soil bacterial activity on soybean growth. …”
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Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets by Carlotta De Filippo, Sofia Chioccioli, Niccolò Meriggi, Antonio Dario Troise, Francesco Vitali, Mariela Mejia Monroy, Serdar Özsezen, Katia Tortora, Aurélie Balvay, Claire Maudet, Nathalie Naud, Edwin Fouché, Charline Buisson, Jacques Dupuy, Valérie Bézirard, Sylvie Chevolleau, Valérie Tondereau, Vassilia Theodorou, Claire Maslo, Perrine Aubry, Camille Etienne, Lisa Giovannelli, Vincenzo Longo, Andrea Scaloni, Duccio Cavalieri, Jildau Bouwman, Fabrice Pierre, Philippe Gérard, Françoise Guéraud, Giovanna Caderni

“…In germ-free rats, FMT induced changes reminiscent of dietary effects, including heightened preneoplastic lesions in MBD rats and the transmission of specific diet-related bacterial and metabolic profiles. …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…Here, we found a single nucleotide change in the vapBC toxin:antitoxin system that stabilizes the large virulence plasmid of Shigella sonnei. …”
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Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats by Enes Aydın, Serpil Mungan Durankaya, Osman Yilmaz, Günay Kirkim, Safiye Aktaş, Salim Neşelioğlu, Özcan Erel, Yüksel Olgun, Abdullah Dalgıç

“…After sacrificing the rats, the right and left temporal bones of each rat were removed and stained with hematoxylin eosin for histological studies to explore any pyknotic changes in spiral ganglion cells. Results: Intergroup comparisons by frequency on day 5 of noise exposure showed statistically significantly lower responses in ABR measurements at 8 kHz, 12 kHz, and 16 kHz in group 2 compared to group 3 (P = .003, P=.006, and P=.002). …”
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Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial by Norberto Chavez-Tapia, Muneeba Ahsan Sayeed, Shobha Luxmi, Douglas J. Kasper, Fenchao Xue, Yang Shen, Weiliang Fan, Wei Yuan, Bin Du

“…Compare to placebo, SIR1-365 significantly increased arterial oxygenation from baseline to day 7 (least-squares mean change [standard error]: 109.4 [26.4] vs. -24.2 [23.6]; P=0.0095), significantly reduced hospitalization duration after treatment (mean±standard deviation: [4.7±3.7] days vs. [8.6±5.6] days; P=0.0145) and respiratory failure incidence (8.3% vs. 38.1%; two-sided P=0.0291) during the study, and numerically shortened the time to clinical improvement in World Health Organization ordinal scale (median: 5.0 days vs. 9.0 days, P=0.0766). …”
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Ascorbic acid-containing compound efficacy in ischemic brain damage by Rita M. Termulaeva, Konstantin Y. Belanov, Natalya D. Bunyatyan, Aleksander S. Pirozhkov, Dmitrii E. Timoshkin, Ekaterina V. Blinova, Olga V. Vasilkina, Kirill D. Blinov, Elena V. Semeleva, Aleksander A. Dmitriev, Dmitrii S. Blinov

“…Cell-protective effect of 3-EA involves changes in the basal and ischemia/reoxygenation-induced expression of genes encoding anti-apoptotic proteins and oxidative status proteins, which leads to inhibition of the late irreversible stages of apoptosis. …”
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