Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…Senescence β-galactosidase (SA-β-Gal) staining kit was employed to detect the change of SA-β-Gal level in the cells. Results‍　‍There obtained 145 potential targets of bergapten for OA. …”
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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…The primary endpoint is the semaglutide–placebo difference on change from baseline to week 104 in the Clinical Dementia Rating – Sum of Boxes score. …”
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Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia by Sicong Yu, Yicheng Xiong, Guangtao Lu, Xiangqing Xiong

“…According to the score of the Pittsburgh sleep quality index (PSQI), the participating patients were divided into four groups: control group (control group), mild sleep disorder group A (group A), moderate sleep disorder group B (group B), and severe sleep disorder group C (group C), with 30 patients in each group. The changes of mean arterial pressure (MAP) and heart rate (HR) at different time points, operation time, anesthesia time, extubation time, the time when Aldrete score reached 10 points, visual analog score (VAS) serum interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) were compared among different groups. …”
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Linear Programming as a Tool for Managing the Training Process of Esports Teams by Oksana Shynkaruk, Nataliia Byshevets, Alla Aloshyna, Olena Iakovenko, Kostiantyn Serhiienko, Valerii Pinchuk, Oleksandr Petryk, Ivan Lut

“…Variant 2 facilitates the investigation of different scenarios for planning the training process of esports teams, demonstrating how the distribution of time across training types changes depending on set goals and preparation phases. …”
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Characteristics and Influencing Factors of Soil CH4 and N2O Fluxes in Typical Broad-leaved Forests in the Yangtze River Delta Region, China by JIA Qinqi, XU Fei, CHEN Bingjiang, LU Yanran, CHEN Lihan, HU Jiahao, GUO Na, FANG Shuangxi

“…To explore the characteristics of changes in CH4 and N2O fluxes in the forest ecosystem soil in this region, as well as the effects of soil physicochemical properties and litter on these two greenhouse gas fluxes. …”
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Differential use of multiple food sources at a bathyal benthic ecosystem in the central Sagami Bay revealed by amino acid nitrogen isotopic compositions by Hidetaka Nomaki, Yoshito Chikaraishi, Nanako O. Ogawa, Koh Maki, Motohiro Shimanaga, Hisami Suga, Masashi Tsuchiya, Toshi Nagata, Naohiko Ohkouchi

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Mindfulness Intervention for Health Information Avoidance in Older Adults: Mixed Methods Study by Chenyu Gu, Liquan Qian, Xiaojie Zhuo

“…However, cyberchondria levels did not change significantly (Mt1=2.848, Mt2=2.685, P=.18). …”
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Adaptability of spring oat yield in the environments of the Near-Irtysh area in Omsk Province by P. N. Nikolaev, N. I. Aniskov, O. A. Yusova, I. V. Safonova

“…This situation may be changed by identifying, developing and introducing new oat cultivars. …”
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Exploring the Use of Smartwatches and Activity Trackers for Health-Related Purposes for Children Aged 5 to 11 years: Systematic Review by Lauren Thompson, Sydney Charitos, Jon Bird, Paul Marshall, Amberly Brigden

“… Background Digital health interventions targeting behavior change are promising in adults and adolescents; however, less attention has been given to younger children. …”
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The effectiveness of providing training and ongoing support to foster cultural humility in volunteers serving as mentors to youth of color: a mixed-methods study protocol by Bernadette Sánchez, Amy J. Anderson, Carla Herrera, David L. DuBois, Kay Thursby Bourke, Jean K. Sack, So Jung Lee, Karen Burchwell, Lidia Y. Monjaras-Gaytan, Yesenia Garcia-Murillo

“…., ethnic/racial identity, sense of mattering, efficacy) aligned with the theory of change, are collected at multiple time points within 12 months from mentors, youth and their parent/guardian, and BBBS staff. …”
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Simulations suggest offshore wind farms modify low-level jets by D. Quint, D. Quint, J. K. Lundquist, J. K. Lundquist, J. K. Lundquist, D. Rosencrans

“…Because LLJs provide considerable wind resources, it is important to understand how LLJs might change with turbine construction. LLJs also influence moisture and pollution transport; thus, the effects of wind farms on LLJs could also affect the region’s meteorology. …”
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Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease by Jing Xue, Miaomiao Nian, Yangyang Liang, Zeqin Zhu, Zhenyu Hu, Yuanyuan Jia, Shuhong Chi, Juan Chen

“…Methods Single-cell sequencing was used to identify changes in the quantity and function of neutrophils in the lung tissue of a zymosan A (ZYM)-induced interstitial pneumonia arthritis model. …”
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Effects of Low Reynolds Number on Wake-Generated Unsteady Flow of an Axial-Flow Turbine Rotor by Matsunuma Takayuki, Tsutsui Yasukata

“…Reynolds number, based on rotor exit velocity and rotor chord length <math alttext="$Rea_{ext{out}, ext{RT}$"> <mrow> <msub> <mrow> <mo>Re</mo> </mrow> <mrow> <mtext>out</mtext><mo>,</mo><mtext>RT</mtext> </mrow> </msub> </mrow> </math>, was varied from <math alttext="$3.2 imes 10^4$"> <mn>3.2</mn><mo>&times;</mo><msup> <mn>10</mn> <mn>4</mn> </msup> </math> to <math alttext="$12.8imes10^4$"> <mn>12.8</mn><mo>&times;</mo><msup> <mn>10</mn> <mn>4</mn> </msup> </math> at intervals of <math alttext="$1.6 imes 10^4$"> <mn>1.0</mn><mo>&times;</mo><msup> <mn>10</mn> <mn>4</mn> </msup> </math> by changing the flow velocity of the wind tunnel. The time-averaged and time-dependent distributions of velocity and turbulence intensity were analyzed to determine the effect of Reynolds number. …”
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Potentially actionable molecular alterations in particular related to poor oncologic outcomes in salivary gland carcinomas by Julia Pikul, Marcin M. Machnicki, Anna Rzepakowska, Natalia Winiarska, Agnieszka Chudy, Albert Moskowicz, Kacper Król, Łukasz Fus, Grażyna Kostrzewa, Tomasz Stokłosa

“…A targeted next-generation sequencing (NGS) panel was used for the identification of small-scale mutations, focal and chromosomal arm-level copy number changes. The final analysis included selected genes with potential actionable aberrations for targeted therapies and outcome predictions in 37 tumours’ samples. …”
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Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…However, routine continuous monitoring program of insecticide susceptibility and malaria vector composition is required so as to guide future decisions on insecticide use for IRS intervention toward malaria elimination and to track future changes in vector population.…”
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Microbial community succession characteristics in an anaerobic baffled reactor during phenol gradient acclimation by Yuan LI, Chunmei YU, Daqiang CANG

“…We analyzed hydrogen partial pressure, pH, chemical oxygen demand (COD), and phenol concentration to examine changes in reactor performance. The Microbial community dynamics were investigated using Illumina high-throughput sequencing technology. …”
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New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Stu... by Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L

“…Live studies have demonstrated that SD amplifies the atrial electrical rearrangement, structural changes, the infiltration of inflammatory cells, and the heightened presence of YBX1 along with inflammasome elements.Conclusion: The research pinpoints YBX1 as a crucial gene in SD-related AF, possibly influencing its impact via the NOD-like receptor signaling route and the invasion of immune cells. …”
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Geochemical signatures and nanomechanical properties of echinoid tests from nearshore habitats of Florida: environmental and physiological controls on echinoid biomineralization by Przemysław Gorzelak, Luis Torres Jr., Dorota Kołbuk, Tobias B. Grun, Michał Kowalewski

“…Such heterogeneity in Mg distribution within single specimens cannot be ascribed solely to environmental changes, indicating that these echinoids actively regulate their intraskeletal Mg content: the higher magnesium concentration at the tubercles relative to that of the underlying stereom may be interpreted as a strategy for enhancing their mechanical strength to withstand surface friction and wear. …”
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Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor by Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind

“…Sixty-six immune-compromised-RNU rats were implanted with human U-251 N cancer cells, and DCE-MRI data were acquired from all the rat brains. The time-trace of change in the longitudinal-relaxivity (ΔR1) for all animals’ brain voxels was calculated. …”
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Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating Hig... by Xie Y, Yang M, Huang J, Jiang Z

“…Finally, siRNA was utilized to suppress the expression of HDAC3 in Caco2 cells, and the changes in oxidative stress levels before and after hypoxia-reoxygenation in Caco2 cells were observed.Results: A total of 277 OSRGs and 4 HIOSRGs were obtained. …”
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