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Recent updates of centromere proteins in hepatocellular carcinoma: a review
Published 2025-02-01“…The numerous proteins that aggregate on this sequence during cell division are called centromere proteins (CENPs). …”
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Potassium (K) for Citrus Trees
Published 2013-08-01“…Potassium is necessary for several basic physiological functions such as the formation of sugars and starch, synthesis of proteins, normal cell division and growth, and neutralization of organic acids. …”
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Published 2025-02-01“…NMM exhibited a minimum inhibitory concentration (MIC) of 5 μM against S. aureus USA300, impacting cell division and the cell wall by repressing the expressions of genes in the division cell wall (dcw) gene cluster. …”
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The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation
Published 2025-04-01“…The post-translational redox regulation of protein function by cysteine oxidation controls diverse biological processes, from cell division to death. However, most current site-centric paradigms fail to capture the nonlinear and emergent nature of redox regulation in proteins with multiple cysteines. …”
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Impact of trainability on telomere dynamics of pet dogs (Canis lupus familiaris): An explorative study in aging dogs.
Published 2025-01-01“…Telomeres, essential for maintaining genomic integrity, undergo shortening with each cell division, leading to cellular senescence. Previous studies in humans have linked cognitive and social factors with telomere dynamics but in animals, such associations remain understudied. …”
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Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells
Published 2024-01-01“…Cells that can overcome senescence can proliferate as defective symmetric cell division, paving the way for malignancy and polyploid giant cancer cell cancers. …”
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Single cell suppression profiling of human regulatory T cells
Published 2025-02-01“…To overcome this limitation, we here develop ‘single cell suppression profiling of human Tregs’ (scSPOT). scSPOT uses a 52-marker CyTOF panel, a cell division detection algorithm, and a whole PBMC system to assess the effect of Tregs on all other cell types simultaneously. …”
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Microscopic origin of the spatial and temporal precision in biological systems
Published 2025-03-01“…In cell-size regulation, it is argued that a balance between stochastic cell growth and cell division processes leads to a narrow distribution of cell sizes. …”
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The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB)
Published 2024-06-01“…The cells lose their stemness and differentiation potential but persist in proliferation as low-grade polyploids (4n) through defective symmetric cell division (DSCD). Genomic integrity can be restored through homotypic cell and nuclear fusion, resulting in the formation of high-grade polyploids known as multinucleated genome repair syncytia, or by inductive hyperpolyploidization of more than 64n, as observed in single-celled polyploid giant cancer cells. …”
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CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance
Published 2025-02-01“…Abstract Cell division cycle associated 7 (CDCA7) plays a role in various malignancies, especially pancreatic cancer (PC). …”
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Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length
Published 2025-02-01“…Abstract Telomeres shorten with each cell division, serving as biomarkers of aging, with human tissues exhibiting short telomeres and restricted telomerase expression. …”
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Comparative gametogenesis and genomic signatures associated with pollen sterility in the seedless mutant of grapevine
Published 2025-02-01“…Conclusion The study showed the downregulation of transcription factors and their target genes involved in cell division, gibberellin biosynthesis and signalling, cell wall development, organization, and pollen germination. …”
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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t...
Published 2025-02-01“…We have also shown evidence of a distinct enrichment in pathways signatures that define processes such as Ca2+ ion homeostasis, cell division, phagosome, autophagy, senescence, cytokine/cytokine receptor interactions, Th17 and Th1/Th2 cell differentiation in Cd38-/- versus WT samples, which reflected the milder inflammatory and autoimmune response elicited in Cd38-/- mice relative to WT counterparts in response to the allogeneic challenge. …”
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