Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau by Feifei Cheng, Ren-Juan Shen, Zhili Zheng, Zhen Ji Chen, Peng-Juan Huang, Zhuo-Kun Feng, Xiaoman Li, Na Lin, Meiqin Zheng, Yuanbo Liang, Jia Qu, Fan Lu, Zi-Bing Jin, Jian Yang

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Common signatures of neutrophils in diverse disease conditions by Di Wu, Ying Cao, Hongjie Chen, Minghao Du, Tingting Wang, Jiarui Zhao, Mengyuan Li, Wenjing Wu, Huixuan Zhang, Ence Yang, Jing Yang, Jian Chen

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Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies by Xiao He, Weiyu Tao, Yunlu Kang, Jiaxuan Xu, Xiaoyu Liu, Lei Chen

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Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland by Zuobao Lin, Yajing Guo, Huiru Bai, Xiaoqin Liu, Meizhen Lin, Yue Zhang, Ruolan Tang, Tian’en Hu, Lili Yu, Chunhui Wang, Shang Cai

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Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo by Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang

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Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis by Pu Tian, Qiuyao Wu, Dasa He, Wenjing Zhao, Lichao Luo, Zhenchang Jia, Wenqian Luo, Xianzhe Lv, Yanan Liu, Yuan Wang, Qian Wang, Peiyuan Zhang, Yajun Liang, Qifeng Yang, Guohong Hu

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Inhaled bispecific single-domain antibody BM219 for mild-to-moderate COVID-19: a double-blind, randomized, placebo-controlled phase 2 trial by Yanling Wu, Yuan Li, Ping Zhang, Siwei Guo, Fang Yuan, Vivian Liu, Ting Yu, Feng Lin, Nan Yang, Chao Tu, Hongzhou Lu, Tianlei Ying, Xin Li

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The second messenger c-di-AMP controls natural competence via ComFB signaling protein by Sherihan Samir, Sofía Doello, Andreas M. Enkerlin, Erik Zimmer, Michael Haffner, Teresa Müller, Lisa Dengler, Stilianos P. Lambidis, Shamphavi Sivabalasarma, Sonja-Verena Albers, Khaled A. Selim

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Structural basis for tRNA mimicry by mascRNA and menRNA by Yuanlin He, Jie Deng, Xiaowei Lin, Zhizhong Lu, Liangliang Wang, Liang Xu, Yin Zhang, Jia Wang, Lin Huang

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Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling by Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu

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Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development by Yaoyu Sun, Min Li, Chao Ning, Lei Gao, Zhenbo Liu, Suijuan Zhong, Junjie Lv, Yuwen Ke, Xinxin Wang, Qiang Ma, Zeyuan Liu, Shuaishuai Wu, Hao Yu, Fangqi Zhao, Jun Zhang, Qian Gong, Jiang Liu, Qian Wu, Xiaoqun Wang, Xuepeng Chen

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A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline by Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Ming Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang

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RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease by Haixin Li, Xuemin Cai, Changfen Xu, Xinhui Yang, Xiaohan Song, Yuxin Kong, Mei Yang, Qielan Wu, Song Guo Zheng, Yiming Shao, Ping Wang, Jing Zhou, Hua-Bing Li

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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

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Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease by Eswar Kumar Nadendla, Rebecca E. Tweedell, Gary Kasof, Thirumala-Devi Kanneganti

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Structural characterization reveals substrate recognition by the taurine transporter TauT by Hao Xu, Qinru Bai, Han Wang, Jun Zhao, Aiping Guo, Renjie Li, Qihao Chen, Yiqing Wei, Na Li, Zhuo Huang, Yan Zhao

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A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy by Mingzhu Tang, Dade Rong, Xiangzheng Gao, Guang Lu, Haimei Tang, Peng Wang, Ning-Yi Shao, Dajing Xia, Xin-Hua Feng, Wei-Feng He, Weilin Chen, Jia-Hong Lu, Wei Liu, Han-Ming Shen

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The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway by Xueping Zheng, Dongmei Fang, Hao Shan, Beibei Xiao, Denghui Wei, Yingyi Ouyang, Lanqing Huo, Zhonghan Zhang, Yuanzhong Wu, Ruhua Zhang, Tiebang Kang, Ying Gao

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Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis by Xiaole Sheng, Lanfei Jin, Zhengrong Yao, Jiaji Gu, Longtao Zhu, Andi Huang, Junxuan Peng, Xin Xu, Xiaolong Ge, Wei Zhou, Jinghao Sheng, Zhengping Xu, Rongpan Bai

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ShennongAlpha: an AI-driven sharing and collaboration platform for intelligent curation, acquisition, and translation of natural medicinal material knowledge by Zijie Yang, Yongjing Yin, Chaojun Kong, Tiange Chi, Wufan Tao, Yue Zhang, Tian Xu

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