Posterior and Anterior Spinal Fusion for the Management of Deformities in Patients with Parkinson's Disease by Masashi Sato, Takeshi Sainoh, Sumihisa Orita, Kazuyo Yamauchi, Yasuchika Aoki, Tetsuhiro Ishikawa, Masayuki Miyagi, Hiroto Kamoda, Miyako Suzuki, Gou Kubota, Yoshihiro Sakuma, Kazuhide Inage, Yasuhiro Oikawa, Junichi Nakamura, Masashi Takaso, Gen Inoue, Tomoaki Toyone, Kazuhisa Takahashi, Seiji Ohtori

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The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2 by Adam D Longhurst, Kyle Wang, Harsha Garadi Suresh, Mythili Ketavarapu, Henry N Ward, Ian R Jones, Vivek Narayan, Frances V Hundley, Arshia Zernab Hassan, Charles Boone, Chad L Myers, Yin Shen, Vijay Ramani, Brenda J Andrews, David P Toczyski

“…Our results demonstrate a role for PRC2.1, but not PRC2.2, in antagonizing G1 progression in a diversity of cell linages, including chronic myeloid leukemia (CML), breast cancer, and immortalized cell lines.…”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

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Comparative Structural and Biophysical Investigation of <i>Lycosa erythrognatha</i> Toxin I (LyeTx I) and Its Analog LyeTx I-b by Amanda Neves de Souza, Gabriele de Azevedo Cardoso, Lúcio Otávio Nunes, Christopher Aisenbrey, Evgeniy Salnikov, Kelton Rodrigues de Souza, Ahmad Saad, Maria Elena de Lima, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

“…Calcein release studies reveal that both peptides cause vesicle disruption, although DLS measurements and TEM imaging indicate distinct effects on phospholipid vesicle organization. …”
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong by Yin Zhang, Francisco T T Lai, Shirley Chiu Wai Chan, Chak Sing Lau, Xue Li, Eric Yuk Fai Wan, Lung Yi Mak, Celine S L Chui, Ivan F N Hung, Esther Wai Yin Chan, Vincent Ka Chun Yan, Deliang Yang, Carlos Wong, Ian Chi-Kei Wong

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study by Rina Triasih, Yan Mardian, Dewi Lokida, Helmia Farida, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane

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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

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Renal dysfunction contributes to deteriorated survival outcomes in patients with upper and lower gastrointestinal bleeding: insights from a cohort study of 1160 cases by Orsolya Anna Simon, Levente Frim, Nelli Farkas, Zoltán Sipos, Nóra Vörhendi, Eszter Boros, Dániel Pálinkás, Brigitta Teutsch, Patrícia Kalló, Vivien Vass, Andrea Szentesi, Roland Hágendorn, Péter Hegyi, Bálint Erőss, Imre Szabó

“…Impaired kidney function at admission results higher in-hospital mortality in overt all-cause GIB and increases the need of RBC transfusion.…”
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Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…Results: Mutation analysis rules out sequence variations as the cause of the altered MARK4 expression in glioma. …”
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Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity by Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Reza Khorasani, Hamed Haghi-Aminjan, Mahdi Gholami, Mahban Rahimifard, Mona Navaei-Nigjeh, Mohammad Abdollahi

“…Exposure to SA is associated with many health concerns, such as the prevalence of cancer and diabetes mellitus type 2 (DMT2). Many studies suggest that SA induces inflammation and biochemical impairments through different mechanisms, including increasing oxidative stress and altering vital genes such as biochemical and anti-inflammatory. …”
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Indoor, outdoor, and personal exposure to PM2.5 and associated health risk in community-dwelling elderly residents in Fuzhou city, 2021: a cross-sectional study by Shuling KANG, Xin LIN, Kan LIN, Baoying LIU, Chuancheng WU, Jianjun XIANG, Jingwen CHEN, Quan ZHOU

“…Exposure to PAHs in PM2.5 posed a potential carcinogenic risk to the participants, with excess lifetime cancer risks (ELCRs) of 12.74 × 10 – 6 and 1.673 × 10 – 6 for winter and summer exposure, respectively. …”
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Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis by J. Sam Meyer, MSc, Oliver K. Jawitz, MD, MHS, Yury Peysakhovich, MD, Dan Aravot, MD, Matthew G. Hartwig, MD, MHS, Yaron D. Barac, MD, PhD

“…Odds of lung non-use between DBD and DCD donors were significantly associated with blood type, alcohol use, cause of death, smoking history, drug use, death circumstance, ethnicity, gender, hypertension, cancer, age, and lung pO2 on 100% P/F ratio (P < 0.001 for all variables). …”
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Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era by Ayotola Fatola, Michael D. Evans, Jenna Brown, Elizabeth Davis, Andrew Johnson, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Susan Eubanks, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Ming Y. Lim, Nicole K. Kocher, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Marshall Mazepa, Shruti Chaturvedi

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RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…Cell experiments showed that asparagus, through the PI3K/AKT/NF-κB pathway, inhibited the proliferation and migration of MM cells, and caused retardation and apoptosis of MM cells in the G0/G1 phase.Discussion: In this study, the anti-cancer activity of asparagus against MM was demonstrated using network pharmacology, and potential pharmacological mechanisms were inferred using in vitro experimental data.…”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

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Against Futility Judgments for Patients with Prolonged Disorders of Consciousness by William Choi

“… Photo by National Cancer Institute on Unsplash ABSTRACT Medical futility judgments for patients in prolonged disorders of consciousness (PDOC) frequently lead to withdrawal of life-sustaining treatment (LST), which is the leading cause of death for patients with traumatic brain injuries. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…FDA finalizes guidance on placebos and blinding for cancer trials. Regulatory Affairs Professionals Society (RAPS). http://www.raps.org/news-and-articles/news-articles/2019/8/fda-finalizes-guidance-on-placebos-and-blinding-fo. …”
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Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism by Qingling Fan, Guanya Guo, Yinan Hu, Yi Lu, Rui Su, Jiaqi Yang, Erzhuo Xia, Shuoyi Ma, Miao Zhang, Jingbo Wang, Ting Li, Ying Han

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Gastric Outlet Obstruction as the Initial Presentation of Upper Tract Urothelial Carcinoma by Karl Andersen, Sarah Burroughs, Assad Munis, Ryan T. Hoff, Alan Shapiro

“…The most common neoplasms associated with GOO include gastric, pancreatic, and biliary tract cancers. Urinary tract urothelial carcinoma has been a rarely documented cause of GOO.…”
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Erythema Ab Igne due to Heating Pad Use: A Case Report and Review of Clinical Presentation, Prevention, and Complications by Marissa Milchak, Joanne Smucker, Catherine G. Chung, Elizabeth V. Seiverling

“…While this dermatosis carries a favorable prognosis, nonmelanoma skin cancers have been reported to arise within lesions of erythema ab igne. …”
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