Does hospital strategic alliance affect the paediatric service capacity of local hospitals? A difference-in-differences econometric analysis by Zhanchun Feng, Qian Fu, Li Zhang, Xiaolu Yu, Cuiping Xiao, Cuili Yang

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Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial by Jing Tan, Yan Liang, Yong Liu, Wei Jiang, Duo Huang, Ning Tan, Chung-Wah Siu, Jo Jo Hai, Xiaoyu Huang, Jianfeng Ye, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Li-Xue Yin, Ming-Liang Zuo, Kui Kai Lau, Zhen Lei, Yingqing Feng, Bryan P Yan, Wen-Sheng Yue, Wen-Jun Zhang, Yuk-Ming Lau, Hin-Wai LUI, Koon-Ho Chan, Toi Meng Mok, Weng-Chio Tam, Kun-Chong Tam, Xiuhua Feng, Xiaofei Jiang, Guanming Tan, Mario Alberto Evora

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Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei by Marija Krasiļņikova, Catarina A. Marques, Emma M. Briggs, Craig Lapsley, Graham Hamilton, Dario Beraldi, Kathryn Crouch, Richard McCulloch

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A Radiograph Dataset for the Classification, Localization, and Segmentation of Primary Bone Tumors by Shunhan Yao, Yuanxiang Huang, Xiaoyu Wang, Yiwen Zhang, Ian Costa Paixao, Zhikang Wang, Charla Lu Chai, Hongtao Wang, Dinggui Lu, Geoffrey I Webb, Shanshan Li, Yuming Guo, Qingfeng Chen, Jiangning Song

“…Abstract Primary malignant bone tumors are the third highest cause of cancer-related mortality among patients under the age of 20. …”
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High-resolution genetic analysis of whole APC gene deletions: a report of two cases and patient characteristics by Hiroki Tanabe, Yasuyuki Koshizuka, Kazuyuki Tanaka, Kenji Takahashi, Masami Ijiri, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Takeo Sarashina, Kentaro Moriichi, Kenrokuro Mitsube, Yusuke Mizukami, Mikihiro Fujiya, Yoshio Makita

“…Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by germline variants in the APC gene, leading to the development of numerous colorectal polyps and significantly increases the risk of colorectal cancer. …”
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GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma by Zhao-shou Yang, Qin Yang, Xiao-xiao Sun, Kui Xiong, Xiao-ting Zhu, Yi-chen Wang, Qian-yao Ren, Guo-hui Wu, Shi-min Wang, Xu-qin Cao, Xiao-rong Yang, Wen-gong Jiang

“…Furthermore, GPX8 knockdown caused G1 cell cycle arrest, increased cell death, and reduced colony formation in U87MG and U118MG cells. …”
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The Contribution of Secondary Particles Following Carbon Ion Radiotherapy to Soft Errors in CIEDs by Yudai Kawakami, Makoto Sakai, Hiroaki Masuda, Masami Miyajima, Takao Kanzaki, Kazutoshi Kobayashi, Tatsuya Ohno, Hiroshi Sakurai

“…<italic>Introduction:</italic> While carbon ion radiotherapy is highly effective in cancer treatment, it has a high risk of causing soft error, which leads to malfunctions in cardiac implantable electrical devices (CIEDs). …”
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Cell Therapy for Chemically Induced Ovarian Failure in Mice by Paula Terraciano, Tuane Garcez, Laura Ayres, Isabel Durli, Melchiani Baggio, Cristiana Palma Kuhl, Claudia Laurino, Eduardo Passos, Ana Helena Paz, Elizabeth Cirne-Lima

“…Cell therapy has been linked to an unexplained return of ovarian function and fertility in some cancer survivors. Studies modeling this in mice have shown that cells transplantation generates donor-derived oocytes in chemotherapy-treated recipients. …”
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Catastrophic Brain Aspergillosis after Liver Transplantation by Mohammadmahdi Abbasi, Shirin Shams Ardakani, Nasir Fakhar, Hamid Eshaghi, Hosein Alimadadi, Toktam Faghihi, Behdad Gharib, Meisam Sharifzadeh, Masoomeh Safaei

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Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages by Yea-Jin Park, Se-Yun Cheon, Dong-Sung Lee, Divina C. Cominguez, Zhiyun Zhang, Sangwoo Lee, Hyo-Jin An

“…A hypernomic reaction or an abnormal inflammatory process could cause a series of diseases, such as cardiovascular disease, neurodegeneration, and cancer. …”
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A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies by Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy, Bo Porse, Kirsten Grønbæk

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Chronological trend of social contact patterns in Japan after the emergence of COVID-19 by Hwichang Jeong, Sehyun Park, June Young Chun, Norio Ohmagari, Yongdai Kim, Shinya Tsuzuki

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Thapsigargin Induces Apoptosis by Impairing Cytoskeleton Dynamics in Human Lung Adenocarcinoma Cells by Fei Wang, Da-zhong Liu, Hao Xu, Yi Li, Wei Wang, Bai-lu Liu, Lin-you Zhang

“…These alternations may be caused by the inhibition of of mTORC1 activities (indicated by pS6 (Ser240/244)) and RhoA pathways after thapsigargin treatment. …”
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AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…However, radiotherapy resistance is the main cause of therapeutic failure in patients. Our previous study revealed that Adiponectin Receptor 1 (AdipoR1) is involved in regulating radiation resistance in liver cancer patients treated with stereotactic body radiotherapy. …”
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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro by Yang Li, Jianfang Dong, Peiran Zhao, Ping Hu, Dawei Yang, Lei Gao, Lianzhi Li

“…All these complexes displayed moderate cytotoxicity toward esophageal cancer cell line Eca-109 with the IC50 values of 23.95 ± 2.54 μM for 1, 18.14 ± 2.39 μM for 2, and 21.89 ± 3.19 μM for 3. …”
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β-hydroxy-β-methylbutyrate-enriched nutritional supplements for obese adults during weight loss: study protocol of a randomised, double-blind, placebo-controlled clinical trial by Ming Yang, Xiaofan Jing, Yuxiang Liang, Renjie Wang, Hongbo Fu, Jiaojiao Jiang

“…To maintain a healthy weight, dieting and lifestyle changes are the first-line interventions; however, these interventions are of poor compliance and may cause body composition changes, mainly skeletal muscle wasting (sarcopenia). …”
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The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease... by Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanesh

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Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines by Wei-Yi Lei, Shih-Chieh Hsiung, Shao-Hsuan Wen, Chin-Hsuan Hsieh, Chien-Lin Chen, Christopher Glenn Wallace, Chien-Chung Chang, Shuen-Kuei Liao

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When math legitimizes knowledge: a step by step approach to Bayes’ rule in diagnostic reasoning by Yung Bruno de Mello Gonzaga, André Demambre Bacchi, Vitor Borin Pardo de Souza

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Ecological and human health implications of mercury contamination in the coastal water by A. Mallongi, A.U. Rauf, R.D.P. Astuti, S. Palutturi, H. Ishak

“…From the simulation results, the concentration of mercury at 23.3% and exposure time of 21.3 percent were the most influential and dominant factors in non-cancer risk for adults and children, respectively. …”
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