Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa by Hyuk Chan Kwon, Sup Kim, Sheng Jin, Sun-Ae Shin, Jeong Han Lee, Min Jung Park, Soo Jeong Kim, Yong-Ho Park

“…Abstract Radiotherapy (RTx) is a highly effective treatment for head and neck cancer that can cause concurrent damage to surrounding healthy tissues. …”
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Comparative Antiviral Efficacy of Generic Sofosbuvir versus Brand Name Sofosbuvir with Ribavirin for the Treatment of Hepatitis C by L. Tang, M. Kamat, A. Shukla, M. Vora, C. Kalal, S. Kottilil, S. Shah

“…Chronic hepatitis C infection is a major cause for liver failure and liver cancer and can be treated with highly effective all oral directly acting antiviral (DAA) drugs. …”
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Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury by Akemi Tsutsui, Yasuni Nakanuma, Kouichi Takaguchi, Satoko Nakamura, Hiroshi Shibata, Nobuyuki Baba, Tomonori Senoh, Takuya Nagano, Hiroko Ikeda

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Influence of Process Parameters on Content Uniformity of a Low Dose Active Pharmaceutical Ingredient in a Tablet Formulation According to GMP by Muselík Jan, Franc Aleš, Doležel Petr, Goněc Roman, Krondlová Anna, Lukášová Ivana

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Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes by Prasad Sherekar, Sanvidhan G. Suke, Archana Dhok, Srikant Malegaonkar, Shrikrishna A. Dhale

“…Silicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. …”
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miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κB/Inflammatory Signaling Pathway by Bin Xie, Can Lu, Chen Chen, Jianhua Zhou, Zhenghao Deng

“…The present study showed silica exposure caused the decrease in miR-135a level but the increase in inflammatory mediators. …”
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Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…Aim: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, and there is a pressing need to explore novel therapeutic strategies that enhance the efficacy of existing treatments. …”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…Abstract Ineffective medication is a major healthcare problem causing significant patient suffering and economic costs. …”
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Methods of massive parallel reporter assays for investigation of enhancers by S. E. Romanov, D. A. Kalashnikova, P. P. Laktionov

“…Alterations of gene regulatory elements may cause various pathologies, including cancer, congenital disorders and autoimmune diseases. …”
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Frequency and Treatment Outcome of Invasive Fungal Infections in Children with Hematological Malignancies by Rabiha Manzoor, Rabia Tariq, Awais Arshed, Qurat Ul Ain Ali, Ajaz Ahmed, Fozia Sayed Rasool

“… Background: Invasive fungal infections are the cause of significant morbidity and mortality among cancer patients of any age group. …”
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Crystal Guava (Psidium guajava L. “Crystal”): Evaluation of In Vitro Antioxidant Capacities and Phytochemical Content by Rika Hartati, Hashifah I. Nadifan, Irda Fidrianny

“…Free radicals can cause many diseases, such as cancer. Antioxidant is a compound that could scavenge free radicals. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…Helicobacter pylori is a gram-negative bacterium that persistently infects the human stomach, leading to peptic ulcers, gastritis, and an increased risk of gastric cancer. The extremophilic characteristics of this bacterium make it resistant to current drug treatments, and there are no licensed vaccines available against H. pylori. …”
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Pathogenic and therapeutic role of bile acids at reflux-gastritis by T. L. Lapina, I. M. Kartavenko, V. T. Ivashkin

“…Increase of endocellular calcium stimulates secretion of pepsinogen and acid production in the stomach,  that in the case of decreased cytoprotective factors by DGR can cause changes mucosal injury. According to the modern point of view bile acids are associated with a lot of neoplasms of digestive organs, including esophageal, stomach, small intestine, liver, pancreas and colorectal cancer. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Multiple myeloma (MM) is an intractable hematological malignancy caused by abnormalities in plasma cells. Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. …”
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A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons by Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni

“…The JC virus ( JCV) is well known for causing progressive multifocal leukoencephalopathy (PML), a potentially fatal, demyelinating disease of the central nervous system (CNS). …”
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Bilothorax: A Case Report and Systematic Literature Review of the Rare Entity by Roshan Acharya, Smita Kafle, Yub Raj Sedhai, Dhan Bahadur Shrestha, Kevin Walsh, Wasif Elahi Shamsi, Suraj Gyawali, Nikita Acharya, Anthony Lukas Loschner, Edmundo Raul Rubio

“…Most of the patients with mortality had advanced hepatobiliary cancer and were noted to die of complications not related to bilothorax. …”
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The outcomes of recent patient safety education interventions for trainee physicians and medical students: a systematic review by Charles Vincent, Nick Sevdalis, Sonal Arora, Paul Baker, Matthew A Kirkman, Maria Ahmed

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Anthropometric and Biochemical Correlations of Insulin Resistance in a Middle-Aged Maltese Caucasian Population by Rachel Agius, Nikolai Paul Pace, Stephen Fava

“…Insulin resistance (IR) is associated with increased cardiovascular disease risk, and with increased all-cause, cardiovascular, and cancer mortality. A number of surrogate markers are used in clinical practice to diagnose IR. …”
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Assessing the health and economic burden of obesity-related complications in East-Asian populations: implementation of risk equations in the Core Obesity Model for Japan and model... by Ichiro Tatsuno, Mark Lamotte, Laetitia Gerlier, Anamaria-Vera Olivieri, James Baker-Knight

“…Internal and external validation were performed.Results Overall, good internal validity was achieved, with mild underestimation for diabetes, cardiovascular and all-cause death taken together (ordinary least squares linear regression [OLS-LRL] 0.8844), moderate overestimation of TKR and cancers (OLS-LRL 1.267) and a slight underestimation for NAFLD and hyperuricaemia (OLS-LRL 0.934). …”
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Meta-Analysis of Integrated Therapeutic Methods in Noninvasive Lower Back Pain Therapy (LBP): The Role of Interdisciplinary Functional Diagnostics by Aleksandra Bitenc-Jasiejko, Krzysztof Konior, Danuta Lietz-Kijak

“…Quite often, it is a consequence of many years of disturbed distribution of tension within the human body caused by local conditions (injuries, hernias, stenoses, spondylolisthesis, cancer, etc.), global factors (postural defects, structural integration disorders, lifestyle, type of activity, etc.), or systemic diseases (connective tissue, inflammation, tumours, abdominal aneurysm, and kidney diseases, including urolithiasis, endometriosis, and prostatitis). …”
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