Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

“…Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs, but often result in aggregation-caused quenching (ACQ) effects, preventing site-specific activation.MethodsWe exploited manganese (Mn2+)–pyrochloric acid (PPa) nanocomplexes coordinated using the photosensitizer PPa and metal Mn ion for the treatment of osteosarcoma. …”
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A Lifelong Smoker with Hypopituitarism: Rethinking the Hypothesis of a Tumor in the Hypophysis by Nestoras Mathioudakis, Alfredo Quinones-Hinojosa, Roberto Salvatori, Shehzad Basaria

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Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis by Min Wei, Qiaoji Jiang, Shuang Bian, Pengzhao Chang, Bangbang Li, Changzhou Shi, Yangang Zhu, Yanchen Wang, Pingfu Hou, Jingjing Li

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A Human/Murine Chimeric Fab Antibody Neutralizes Anthrax Lethal Toxin In Vitro by Guipeng Ding, Ximin Chen, Jin Zhu, Nicholas S. Duesbery, Xunjia Cheng, Brian Cao

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Applying Machine Learning Techniques to Identify Undiagnosed Patients with Exocrine Pancreatic Insufficiency by Bruce Pyenson, Maggie Alston, Jeffrey Gomberg, Feng Han, Nikhil Khandelwal, Motoharu Dei, Monica Son, Jaime Vora

“…**Background:** Exocrine pancreatic insufficiency (EPI) is a serious condition characterized by a lack of functional exocrine pancreatic enzymes and the resultant inability to properly digest nutrients. EPI can be caused by a variety of disorders, including chronic pancreatitis, pancreatic cancer, and celiac disease. …”
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Biphasic Chromatin Structure and FISH Signals Reflect Intranuclear Order by Jyoti P. Chaudhuri, Eva Kasprzycki, Mathew Battaglia, John R. McGill, Anton Brøgger, Joachim-U. Walther, Albrecht Reith

“…Similarly, a genome-wide monoallelic replication may tilt the balance of heterozygosity resulting in aneusomy, initiating early events in malignant transformation and in predicting cancer mortality.…”
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Symptoms affecting patient’s intake of food with lymphoma in outpatient chemotherapy by Andressa Madalozo Laffitte, Carolina Lane Alves Farias, Jessica Wszolek

“…Lymphomas are a malignant neoplasm which arises in the lymph nodes, which are involved in fighting infection. This cancer had the highest increase in incidence among oncohematological diseases. …”
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Is hypercalcaemia immediately life-threatening? A prospective study by David Trewick, Mathilde Le Borgne, Julie Regnault, Camille Guimard

“…Results: The median calcium concentration was 3.3 mmol/L (3.1–3.7). Cancer was the first cause of hypercalcaemia. No patient presented a life-threatening cardiac arrhythmia during their stay in the ED. …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Excess reactive oxygen species (ROS) production is very harmful to cell constituents, especially proteins, lipids, and DNA, thus causing damage to the cell. Oxidative stress has been associated with a variety of pathologic conditions, including diabetes mellitus (DM), cancer, atherosclerosis, neurodegenerative diseases, rheumatoid arthritis, ischemia/reperfusion injury, obstructive sleep apnea, and accelerated aging. …”
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Efficacy of endoscopic vacuum therapy in esophageal luminal defects: a systematic review and meta-analysis by Ishaan Vohra, Harishankar Gopakumar, Neil R. Sharma, Srinivas R. Puli

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The Use of Noninvasive Velacur® for Discriminating between Volunteers and Patients with Chronic Liver Disease: A Feasibility Study by Michael P. Curry, Edward Tam, Caitlin Schneider, Noha Abdelgelil, Tarek Hassanien, Nezam H. Afdhal

“…Nonalcoholic fatty liver disease is the leading cause of chronic liver disease globally and can progress to cirrhosis, liver failure, and liver cancer. …”
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C-reactive protein as a diagnostic marker for ovarian carcinoma by Angga Dewi Umar Wahyu, Syahrul Rauf, Susiawaty Susiawaty, Maisuri T. Chalid, Nugraha Utama Pelupessy, Irma Savitri

“… Ovarian carcinoma is a leading cause of death in gynecological cancers, making early detection crucial for improving survival rates. …”
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Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration by Junyu Zhang, Yu Zhou

“…Age-related macular degeneration (AMD) is the leading cause of severe, permanent vision loss among the elderly in the developed world. …”
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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives by Zahra Khosroabadi, Samaneh Azaryar, Hassan Dianat-Moghadam, Zohreh Amoozgar, Mohammadreza Sharifi

“…Abstract Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. …”
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A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and exhibits a poor outcome. …”
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Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway by Wedad S. Sarawi, Hala A. Attia, Afraa Alzoubi, Nour Alanazi, Raeesa Mohammad, Rehab A. Ali

“…Abstract Tamoxifen (TAM) is extensively used to manage estrogen receptor-positive breast cancer. Despite its effectiveness, its administration can negatively impact various organs, including the liver. …”
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Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 by Hilmi Farhan Ramadhani, Annisa Annisa, Aryo Tedjo, Dimas R. Noor, Wisnu Ananta Kusuma

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Tumor Markers in Pleural Fluid: A Comprehensive Study on Diagnostic Accuracy by Vladimir Aleksiev, Daniel Markov, Kristian Bechev

“…These effusions are a leading cause of debilitating dyspnea and a diminished quality of life among cancer patients, with distant metastasis to the pleural layers occurring in about 20% of cases during treatment. …”
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Impact of interferon-free regimens in patients with chronic HCV and successfully ablated HCC by Amr Maged Mahmoud Rasheed, Maissa E. L. Raziky, Mohammad El Sayed, Mai Mehrez, Gamal Esmat

“…Abstract Background Hepatocellular carcinoma (HCC) ranks sixth amongst all cancers and is the 2nd top cause of mortality attributable to cancer. …”
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