Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin by Wen-Tsan Chang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Chien-Chih Chiu, King-Teh Lee, Kee-Lung Chang

“…Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Epirubicin can induce intracellular reactive oxygen species and is widely used to treat unresectable HCC. …”
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Phylostratigraphic analysis of gene networks of human diseases by Z. S. Mustafin, S. A. Lashin, Yu. G. Matushkin

“…It was also shown that among the gene networks analyzed, the highest proportion of evolutionarily young genes was found in the networks associated with diseases of the immune system (65 %), and the highest proportion of evolutionarily ancient genes was found in the networks responsible for the formation of human dependence on substances that cause addiction to chemical compounds (88 %); gene networks responsible for the development of infectious diseases caused by parasites are signif icantly enriched for evolutionarily young genes, and gene networks responsible for the development of specif ic types of cancer are signif icantly enriched for evolutionarily ancient genes.…”
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Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review by Yingbo Gong, Xin Wang, Zhi Zhu

“…There have been no reports of PMP originating from a transverse colonic mucinous adenocarcinoma and causing metastatic mucinous adenocarcinoma. Case Presentation. …”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…Ataxia Telangiectasia (A-T) is a rare, autosomal recessive genetic disorder characterized by a variety of symptoms, including progressive neurodegeneration, telangiectasia, immunodeficiency, and an increased susceptibility to cancer. It is caused by bi-allelic mutations impacting a gene encoding a serine/threonine kinase ATM (Ataxia Telangiectasia Mutated), which plays a crucial role in DNA repair and maintenance of genomic stability. …”
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Helicobacter pylori: From Bench to Bedside by N Chiba, A Matisko, P Sinclair, ABR Thomson

“…It is now recognized that H pylori is a chronic infection of the stomach causing inflammation. Some patients remain asymptomatic, while others may develop dyspepsia, duodenal or gastric ulcer, gastric cancer or a mucosa-associated lymphoid tissue lymphoma. …”
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Relationship between oxidative stress biomarkers and micronuclei scoring as a biomarker for DNA damage in Egyptian nicotine-dependent smokers: A cross-sectional study by Asmaa Mahmoud Mohammed, Dalia Farouk, Adel F. Hashish

“…Background/aim About one-fifth of cancer deaths are caused by tobacco smoking. Nicotine-related DNA damage is thought to be the result of oxidative stress, whereas DNA damage can be represented in the form of binucleated micronuclei (BMNi). …”
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The 500-year Cultural & Economic Trajectory of Tobacco: A Circle Complete by Christopher A. Jones, Amanda Wassel, William Mierse, E. Scott Sills

“…Its use in all forms represents the world’s single greatest cause of preventable disease and death. Tobacco was introduced to Europe by Christopher Columbus, who in October 1492 discovered the crop in Cuba. …”
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Electroanalytical Methods as a Tool for Determining the Antioxidant Capacity in Blood Samples by Fernanda Gonçalves de Oliveira, Thiago da Silveira Alvares, Rodrigo de Siqueira Melo

“… Aerobic metabolism is an essential process for energy production in cells, but it also generates reactive oxygen species (ROS), which, in excess, can cause cellular damage and contribute to the development of various diseases, such as cardiovascular diseases, cancer, and neurodegenerative disorders. …”
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Smoking among pregnant women attending philanthropic maternity in São Paulo (Br by Natália Machado Costa Lopes, Maria Alice Tsunechiro, Alfredo Almeida Pina-Oliveira, Anna Maria Chiesa

“…About the harms to ma- ternal health, cancer was the most remembered. It was observed that it is necessary to intensify the approach of smoking at prenatal period, warning pregnant women about the risks and harms caused by cigarette for both the mother and the newborn, as there are still a lot of women who do not know basic information about the subject.…”
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Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis by Sadichhya Lohani, Emily Schuiteman, Lohit Garg, Dhiraj Yadav, Sami Zarouk

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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…Other studies seek to pharmacologically aggravate chronic ER stress in cancer cells in order to enhance apoptosis and achieve tumor cell death. …”
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Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis by Zhe Yuan, Lei Liu, Jingyang Wu, Desheng Huang, Jin Geng

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Intra-Abdominal Bleeding during Pregnancy, Preterm Delivery, and Placental Polyp in a Long-Term Survivor of Neuroblastoma: A Case Report by Noriyoshi Watanabe, Junna Tsutsui, Satsuki Kakiuchi, Seung Chik Jwa, Hironori Takahashi, Naomi Kato, Nobuaki Ozawa, Haruhiko Sago, Michihiro Kitagawa

“…She also had a placental polyp and developed massive postpartum bleeding. Conclusion. Cancer treatment, especially radiation therapy, in childhood may cause adverse outcomes during pregnancy in long-term survivors of neuroblastoma.…”
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COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis by Sasmit Roy, Srikanth Kunaparaju, Narayana Murty Koduri, Vikram Sangani, Mytri Pokal, Venu Madhav Konala, Mamtha Balla, Sreedhar Adapa

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New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy by Mengran Li, Mengran Li, Hu Tian, Yanshuang Zhuang, Zili Zhang, Zili Zhang

“…The formation and progression of many diseases, especially cancer, can be attributed to dysregulated m6A alteration, which can cause disturbances in a variety of cellular functions, such as immunological responses, cell proliferation, and differentiation. …”
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SiameseNet based on multiple instance learning for accurate identification of the histological grade of ICC tumors by Zhizhan Fu, Fazhi Feng, Xingguang He, Tongtong Li, Xiansong Li, Jituome Ziluo, Zixing Huang, Jinlin Ye

“…BackgroundAfter hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Timely and accurate identification of ICC histological grade is critical for guiding clinical diagnosis and treatment planning.MethodWe proposed a dual-branch deep neural network (SiameseNet) based on multiple-instance learning and cross-attention mechanisms to address tumor heterogeneity in ICC histological grade prediction. …”
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A Case Report of Obstructive Shock from an Esophageal Bolus Leading to Left Atrial Compression by Sharmin Kalam, Sergio Marquez, Emmelyn J. Samones, Tammy Phan, Vi Am Dinh

“…Cardiac tamponade compresses cardiac chambers, particularly the left atrium, causing decreased end-diastolic volume and cardiac output. …”
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasingly used in therapy, its metabolism and effects on the organism are still not described in detail. …”
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Prompt injection attacks on vision language models in oncology by Jan Clusmann, Dyke Ferber, Isabella C. Wiest, Carolin V. Schneider, Titus J. Brinker, Sebastian Foersch, Daniel Truhn, Jakob Nikolas Kather

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Plant Sources, Extraction Methods, and Uses of Squalene by M. Azalia Lozano-Grande, Shela Gorinstein, Eduardo Espitia-Rangel, Gloria Dávila-Ortiz, Alma Leticia Martínez-Ayala

“…Scientific research has shown that SQ reduces skin damage by UV radiation, LDL levels, and cholesterol in the blood, prevents the suffering of cardiovascular diseases, and has antitumor and anticancer effects against ovarian, breast, lung, and colon cancer. The inclusion of SQ in the human diet is recommended without causing health risks; however, its intake is low due to the lack of natural sources of SQ and efficient extraction methods which limit its commercialization. …”
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