Everolimus Implicated in Case of Severe Gastrointestinal Hemorrhage by Paul Gonzales, Seth Klusewitz, Johanna Marowske, John Gancayco, Michael B. Osswald, Robert Setlik

“…Breast cancer remains the leading cause of cancer and the third leading cause of cancer related deaths among our population with an estimated number of 246,660 new cases and 40,450 deaths in 2016. …”
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<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…In Russia, cancer is the second leading cause of death following cardiovascular diseases. …”
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THE ALGORITHM FOR DETERMINING TIMING OF RADIOTHERAPY SESSION COMPONENTS FOR DIFFERENT METHODS OF ONCOLOGY PATIENTS IRRADIATION AT THE STAGE OF RADIOTHERAPY PLANNING by E. V. Titovich, P. A. Patsiapalau, M. I. Piatkevich, M. G. Kiselev

“…The objective of this work was to define components that influence on the treatment session and to develop an algorithm that allows to determine the duration of the patient treatment sessions with the use of different methods of radiotherapy and tumor localization.In order to determine radiation therapy session components, that cause the dominant influence on the session timing, the authors carried out a retrospective analysis of each fraction of the total sample of cancer patients treatment plans with most often irradiated with the use of linear accelerators in the NCCB localizations of tumors (more than 5200 fractions).The appropriate algorithms were designed to assess the results of the analysis of time parameters of radiation therapy oncology patient session during its pre-radiation preparation. …”
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T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis by Dina Soliman, Sherin Sallam, Susanna Akiki, Deena Mudawi, Feryal Ibrahim

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Lobular Mammary Carcinoma Presenting as an Obstructing Rectal Mass by Ebrahim Almahmeed, Eman Aljufairi, Noof Alshaibani

“…Breast cancer is the leading cause of cancer death in women, and while metastasis is common to areas like the bone, lungs, and brain, it is rare to metastasize to the gastrointestinal tract and especially to the rectum. …”
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Pure Primary Ovarian Squamous Cell Carcinoma Perforating the Rectum by Kazuya Mimura, Aiko Okada, Naotsugu Haraguchi, Kenjiro Sawada, Takuji Tomimatsu, Tadashi Kimura

“…Rectal perforation is uncommon in ovarian cancer, even in advanced stages. Pure primary ovarian squamous cell carcinoma is a very rare subtype of ovarian cancer and has not been reported to cause rectal perforation. …”
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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

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Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis by Claire M. Payne, Cheray Crowley-Skillicorn, Hana Holubec, Katerina Dvorak, Carol Bernstein, Mary Pat Moyer, Harinder Garewal, Harris Bernstein

“…Rapamycin (activator of autophagy) pre-treatment of NCM-460 cells significantly (P<.05) decreased, and 3-MA (inhibitor of autophagy) significantly (P<.05) increased the cell loss caused by DOC treatment, alone. Rapamycin pre-treatment of the apoptosis-resistant colon cancer cell line, HCT-116RC (developed in our laboratory), resulted in a significant decrease in DOC-induced cell death. …”
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Optimizing colorectal polyp detection and localization: Impact of RGB color adjustment on CNN performance by Jirakorn Jamrasnarodom, Pharuj Rajborirug, Pises Pisespongsa, Kitsuchart Pasupa

“…Colorectal cancer, arising from adenomatous polyps, is a leading cause of cancer-related mortality, making early detection and removal crucial for preventing cancer progression. …”
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Gastric Intestinal Metaplasia: Demographic and Epidemiological Characterization in Puerto Rican Hispanics (2012-2014) by Jorge J. Cruz-Cruz, María González-Pons, Adrián Cora-Morges, Marievelisse Soto-Salgado, Giancarlo Colón, Kimberly Alicea, Kathia Rosado, Douglas R. Morgan, Marcia Cruz-Correa

“…Background and Aims. Gastric cancer is the 5th leading cause of cancer mortality worldwide and the leading infection-associated cancer. …”
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Tiptoeing on Metastatic Adenocarcinoma of the Lung by Arupreet Kochar, Harrison D. Winters, Li Zhang, Bin Zhang, Kamia Thakur, Rajesh Essrani

“…Lung cancer remains the top cause of cancer-related death in the United States. …”
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Endometrial Carcinoma Presenting as Vasculitic Sensorimotor Polyneuropathy by Marketa Vasku, Thomas Papathemelis, Nicolai Maass, Ivo Meinhold-Heerlein, Dirk Bauerschlag

“…Paraneoplastic syndromes (PNS) are a heterogeneous group of symptoms which are indirectly caused by primary or metastatic tumor. Paraneoplastic polyneuropathy (PNP) is mostly related to small cell lung cancer (5%), prostate, gastric, and breast cancer. …”
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Development of the inner ear and regeneration of hair cells after hearing impairment by Xin Bing, Chengcheng Liu, Xue Cao, Chengzhilin Li, Xiaochen Gao, Fangyuan Zhu, Xinhao Wu, Na Guo, Houyang Hu, Ming Xia, Miaoqing Zhao

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Search for signals of positive selection of circadian rhythm genes <i>PER1</i>, <i>PER2</i>, <i>PER3</i> in different human populations by A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva

“…In addition, many of the selection variants in the PER1, PER2, PER3 genes appear to regulate biological processes that are associated with major modern diseases, including obesity, cancer, metabolic syndrome, bipolar personality disorder, depression, rheumatoid arthritis, diabetes mellitus, lupus erythematosus, stroke and Alzheimer’s disease, making them extremely interesting targets for further research aimed at identifying the genetic causes of human disease.…”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. …”
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The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis by Alexandra Arcilla Xin Hui Sim, Jia Ying Cheam, Jodi Woan-Fei Law, Vengadesh Letchumanan, Yatinesh Kumari, Satoshi Ogawa, Sunny Hei Wong, Kok-Gan Chan, Loh Teng-Hern Tan

“… Colorectal cancer (CRC) remains one of the top cancers in the world. …”
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miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers. …”
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Barrett’s Esophagus: Is It All That Bad? by GNJ Tytgat

“…Because superficial cancers only rarely cause symptoms, detection of cancer at such an early curable state can only be achieved through surveillance of patients at risk. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Radiofrequency ablation combined with immunotherapy to treat hepatocellular carcinoma: a comprehensive review by Gui-Lin Xie, Zhi-Han Zhong, Tai-Wei Ye, Zun-Qiang Xiao

“…Abstract Background and aim Hepatocellular carcinoma (HCC) is a highly immunogenic tumor and the third leading cause of cancer-related deaths worldwide with an increasing incidence. …”
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