Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Large-scale studies have revealed abnormal cancer epigenomes caused by mutations and structural alterations of chromatin modifiers, aberrant DNA methylation, and histone modification signatures. …”
Get full text

Preferences of melanoma patients to accept adjuvant therapy and toxicity – a qualitative substudy of the GerMelaTox-A project by Toni Maria Janke, Laura Moysig, Christine Blome, Katharina C. Kähler

Get full text

Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors by Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang

Get full text

RETRACTED ARTICLE: Construction and validation of a machine learning-based immune-related prognostic model for glioma by Qi Mao, Zhi Qiao, Qiang Wang, Wei Zhao, Haitao Ju

Get full text

Radiation-Induced Heart Disease: A Clinical Update by Syed Wamique Yusuf, Shehzad Sami, Iyad N. Daher

“…Cardiovascular diseases and cancer are the two leading causes of morbidity and mortality worldwide. …”
Get full text

RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis by Alicia K. Morgans, Matthew R. Smith

“…Male osteoporosis is an increasingly recognized problem in aging men. A common cause of male osteoporosis is hypogonadism. Thousands of men with prostate cancer are treated with androgen deprivation therapy, a treatment that dramatically reduces serum testosterone and causes severe hypogonadism. …”
Get full text

Diffuse Pancreatic Carcinoma with Hepatic Metastases by Hoang Quan Nguyen, Ngoc Trinh Thi Pham, Van Trung Hoang, Hoang Anh Thi Van, Chinh Huynh, Duc Thanh Hoang

“…Pancreatic cancer is one of the seven leading causes of cancer death worldwide. …”
Get full text

Pengaruh Art Therapy terhadap Kualitas Hidup Anak Kanker yang Menjalani Kemoterapi by Hidayatul Hasni, Mira Andika, Armein Syahid

“…Continuous chemotherapy causes side effects in children, one of which affects the quality of life of children. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…Cancer is one of the leading causes of death worldwide. …”
Get full text

Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

“…Anemia of cancer and chronic inflammatory diseases is a frequent complication affecting quality of life. …”
Get full text

Morbidity and Mortality Rates from Digestive Diseases in the RF Northwestern Federal District (NWFD) and Measures to Reduce Them by Andrey Yu. Baranovsky, Alexey M. Belyaev, Elina A. Kondrashina

“…Along with a decrease in the incidence of gastric cancer, an increase in the incidence of colorectal cancer, as well as pancreatic cancer, is observed. …”
Get full text

A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia by Sylwia Sasinowska, Pamela Traisak, Michael McCormack, Hala Eid

Get full text

Immunological Perspective: Helicobacter pylori Infection and Gastritis by Hang Yang, Bing Hu

“…It may develop from acute/chronic inflammation, chronic atrophic gastritis, intestinal metaplasia, dysplasia, and intraepithelial neoplasia, eventually to gastric cancer. This review attempts to cover recent studies which provide important insights into how H. pylori causes chronic inflammation and what the characteristic is, which will immunologically explain H. pylori gastritis.…”
Get full text

Increased mortality risk in people with schizophrenia in Lithuania 2001–2020 by Mingaile Drevinskaite, Auguste Kaceniene, Arunas Germanavicius, Giedre Smailyte

“…Abstract The aim of this study was to assess mortality risk in people with schizophrenia in Lithuania from 2001 and 2020. Cause-specific and all-cause mortality risk among patients with schizophrenia was assessed using a retrospective cohort study design. …”
Get full text

Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation by Piyanuch Kongtim, Kai Cao, Stefan O. Ciurea

Get full text

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts by Mariarosaria De Rosa, Ryan P. Barnes, Ariana C. Detwiler, Prasanth R. Nyalapatla, Peter Wipf, Patricia L. Opresko

Get full text

Knowledge and Attitude of Iranian University Students toward Genital Warts by Zeinab Aryanian, Maedeh Mohammadi, Arefeh Babazadeh, Parvaneh Hatami, Zeinab Mohseni Afshar, Azadeh Goodarzi, Ifa Etesami, Mohammad Barary, Soheil Ebrahimpour, Parisa Sabbagh

“…Human papillomavirus (HPV) is one of the well-known causes of cervical cancer and one of the most prevalent sexually transmitted diseases (STDs). …”
Get full text

Report of a Novel Mutation in MLH1 Gene in a Hispanic Family from Puerto Rico Fulfilling Classic Amsterdam Criteria for Lynch Syndrome by Juan M. Marqués-Lespier, Yaritza Diaz-Algorri, Maria Gonzalez-Pons, Marcia Cruz-Correa

“…In Puerto Rico, colorectal cancer (CRC) represents the second leading cause of cancer in men and women. …”
Get full text

Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs by Torić Jelena, Marković Ana Karković, Brala Cvijeta Jakobušić, Barbarić Monika

“…Cancer presents one of the leading causes of death in the world. …”
Get full text

Mistreatment or not the best treatment to the elder. Reality and challenge by Miguel Angel Serra Valdés, Girelda Cordero López, Marleny Viera García

“…Cuba is not exempted of this situation; the Cuban population ages and chronic non communicable diseases are a challenge to be concerned, mainly cancer, dementia, disability and prostration due to different causes which are the most frequent illnesses in elder people.…”
Get full text