Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

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Computerized QT and QTc Measurements From Bedside ICU Monitors Are Similar to Those Derived From a Standard 12‐Lead ECG by Arthur Murray, Karolina Ho, Thomas J. Hoffmann, Gopika K. Ganesh, Shelvin Prasad, Sarah Berger, Cass Sandoval, Amy Larsen, Hildy Schell‐Chaple, Michele M. Pelter

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Impact of moral distress on burn-out: a cross-sectional survey of front-line family physicians during the initial wave of the COVID-19 pandemic by John Billimek, Johanna Shapiro, Cynthia Haq, Tan Nguyen, Avital Sabrina Fischer, Reece Fenning, John Michael Robb, Allison Slater, Uyen Mai, Tien Lam, Jan Paolo De La Cruz

“…The primary objective of this study was to investigate factors contributing to burn-out and moral distress and their relationship among practising family physicians (FPs) in California early in the COVID-19 pandemic.Design Cross-sectional study, online survey evaluating burn-out, moral distress and associated factors.Setting California FPs between July and August 2020 practising in community health centres, hospital systems, private clinics and university systems were surveyed with a 22-item online questionnaire.Participants FPs practising in California were eligible. …”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

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Inhalable biohybrid microrobots: a non-invasive approach for lung treatment by Zhengxing Li, Zhongyuan Guo, Fangyu Zhang, Lei Sun, Hao Luan, Zheng Fang, Jeramy L. Dedrick, Yichen Zhang, Christine Tang, Audrey Zhu, Yiyan Yu, Shichao Ding, Dan Wang, An-Yi Chang, Lu Yin, Lynn M. Russell, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang, Joseph Wang

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Microcephaly protein ANKLE2 promotes Zika virus replication by Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert, Priya S. Shah

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Tricuspid Regurgitation in the Setting of Cardiac Implantable Electronic Devices by Omar M. Aldaas, MD, Gary Ma, MD, Quan Bui, MD, Ryan R. Reeves, MD, Ulrika Birgersdotter-Green, MD

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Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease by Maria Olaru, Amelia Hahn, Maria Shcherbakova, Simon Little, Wolf-Julian Neumann, Reza Abbasi-Asl, Philip A. Starr

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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

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TRACtion: A collaborative, community-researcher agenda-setting approach by Adam Millard-Ball, Juan Matute, Monisha Reginald, Carolyn Pugh, Chase Engelhardt, tamika l butler

“…This paper describes a collaborative, community-based research development process in Southern California, named TRACtion – Transformative Research and Collaboration. …”
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Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Lidocaine safety will be assessed with daily screening questionnaires and lidocaine plasma levels.Ethics and dissemination This study protocol has been approved by the ethics board at the University of California, San Francisco. The results of this study will be published in a peer-review journal and presented at national conferences as poster or oral presentations. …”
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The Association of Food Security With Hypertensive Disorders of Pregnancy: A National Health Interview Survey Analysis by Brittany N. Burton, Alexis Sykes, Cecilia Canales, Andrea J. Ibarra, En Chang, Jonathan Dahan, Adam J. Milam, Tina Yu, Catherine Cha

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Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms by Rujuta Sathe, Gyaneshwar Shrestha, Aria Terango, David Tabibzadeh, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain

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Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data by Caitlin Guccione, Lucas Patel, Yoshihiko Tomofuji, Daniel McDonald, Antonio Gonzalez, Gregory D. Sepich-Poore, Kyuto Sonehara, Mohsen Zakeri, Yang Chen, Amanda Hazel Dilmore, Neil Damle, Sergio E. Baranzini, George Hightower, Teruaki Nakatsuji, Richard L. Gallo, Ben Langmead, Yukinori Okada, Kit Curtius, Rob Knight

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Characterizing suburban soil and microbial properties along a soil age chronosequence by Andie Suratt, Kavisha Behl, Wai Lam Hong, Yae Eun Yoon, Steven D. Allison

“…To address this knowledge gap, we established a chronosequence of residential yards in Southern California to test how urban soils change after development. …”
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Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling by Suguru Saito, Duo‐Yao Cao, Tomohiro Shibata, Yan Liu, Aoi Otagiri‐Hoshi, Xiaojiang Cui, Kenneth E. Bernstein

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Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic... by Partha Ray, Tomoko Hayashi, Karen Messer, Stephen Schoenberger, Aaron Miller, Dennis Carson, Sara McArdle, Zbigniew Mikulski, Jayanth S Shankara Narayanan, Suna Erdem, Herve Tiriac, Minya Pu, Rebekah R White

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Role of imaging in the diagnosis and management of mixed epithelial and stromal tumors of the kidney: Case series and comprehensive review by Kasha Chen, BS, Jasmine Zhao, MD, Ali Sasani, BS, MS, Ryan Sabour, BS, Hannah Cho, BS, Riya Bansal, BS, Chang Shu, BSEE, MSEE, MSCS, Ryan O'Connell, MD, Roozbeh Houshyar, MD

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Contrast-Induced Sialadenitis of the Sublingual Glands by Ki Wan Park, Albert Y. Han, Christine M. Kim, Kenric Tam, Dinesh K. Chhetri

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Hematometrocolpos following Low Transverse Cesarean Delivery Complicated by Uterine Dehiscence by Lauryn C. Gabby, Katherine E. McDaniel, Brian J. Gordon, Laila A. Al-Marayati

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