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41
The Redox System in C. elegans, a Phylogenetic Approach
Published 2012-01-01“…The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals. …”
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42
Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex
Published 2012-01-01“…Recent developments in sequencing and the availability of comprehensive sequence data comprising many species showed that the receptors of the DECTIN-1 cluster are not only homologous to each other but also highly conserved between species. Even in Caenorhabditis elegans, genes displaying homology to the mammalian C-type lectin-like receptors have been detected. …”
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43
Molecular profiling and detection methods of microRNA in cancer research
Published 2020-08-01“…In truth, the first discovery of miRNA was in a simple organism -nematode (scientific name: Caenorhabditis elegans), whereby a mutant displayed aberrant morphological changes. …”
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44
Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms
Published 2011-01-01“…To address this deficit, we use protein sequences from Homo sapiens to query Genbank for homologous proteins in Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae. …”
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45
Nematicidal Action of Microencapsulated Essential Oil of Flesh Fingered Citron
Published 2020-01-01“…The loading capacity was 32.67%, and the embedding yield was 96.24%, assuming that a core-to-wall quality ratio of 1 : 6 is optimal for the carrier. Using Caenorhabditis elegans as a model organism, we explored the toxicity of (1) FFC EO microcapsules (MCs) and (2) four key compounds of the EOs. …”
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46
Finding the Correct Partner: The Meiotic Courtship
Published 2012-01-01“…Other mechanisms leading to homology search are recombination-independent and require specialized pairing sites. In the worm Caenorhabditis elegans, each chromosome carries a pairing center consisting of a chromosome-specific DNA-protein complex, and in the fission yeast Schizosaccharomyces pombe, the sme2 locus encodes a meiosis-specific non-coding RNA that mediates on homologous recognition. …”
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47
Assessment of food toxicology
Published 2016-09-01“…Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) and efforts to integrate organotypic systems and stem cell-based assays. …”
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48
Firing propagation in empirical cognitive networks of human brain
Published 2025-01-01“…So far, in the context of signal propagation, some progress has been achieved on complex networks, especially on the Caenorhabditis elegans network, but little attention has been paid to the empirical cognitive networks of the human brain, which are the networks responsible for cognitive tasks. …”
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49
MIKRORNA – MOLEKUL VERSATIL DALAM KANSER TIROID
Published 2019-07-01“…MikroRNA tidak diendahkan oleh saintis beberapa dekad sebelum ini kerana ia tidak mengekod sebarang protein lantas dianggap jujukan sampah (junk sequence), namun sejak penemuan lin-4 yang mengawalselia perkembangan larva Caenorhabditis elegans, semakin banyak kajian bertumpu ke arah molekul ini. …”
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50
Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i>
Published 2025-01-01“…This review explores the structure and function of the ETC in the context of its role in mtROS generation and regulation, emphasizing its dual roles in cellular damage and signaling. Using <i>Caenorhabditis elegans</i> as a model organism, we discuss how ETC mutations manifest as developmental abnormalities, lifespan alterations, and changes in mtROS levels. …”
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51
Spherical harmonics texture extraction for versatile analysis of biological objects.
Published 2025-01-01“…Our method can also quantify morphological differences in Caenorhabditis elegans germline nuclei, which lack a predefined pattern. …”
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52
Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes
Published 2025-02-01“…Such RNA can cross generational boundaries, as evidenced by somatic double-stranded RNA (dsRNA) in the nematode Caenorhabditis elegans silencing genes of matching sequence in progeny. …”
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53
Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC
Published 2025-02-01“…Brine shrimps, cell lines (A549, Hela, HEPG), and Caenorhabditis elegans were used initially to examine three solanaceous plant extracts (Solanum villosum (SV), Cestrum aurantiacum (CA), and Brugmansia suaveolens (BS)). …”
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54
Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.
Published 2025-01-01“…We analyze here the function of 5 Caenorhabditis elegans bHLH genes, falling into 3 phylogenetically conserved subfamilies, which are continuously expressed in a very small number of postmitotic neurons in the central nervous system. …”
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55
A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans
Published 2025-02-01“…Summary: Vitellogenin is thought to share a common ancestor with human apolipoprotein B (ApoB) for systemic lipid transport. In Caenorhabditis elegans, although a general route for inter-tissue vitellogenin transport has been described, the full mechanism that underlies its intracellular trafficking within the intestine remains obscure. …”
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56
Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK–IDH2 pathway
Published 2023-04-01“…We further showed this in primary hepatocytes, the L02 cell line, and the Caenorhabditis elegans strain. Mechanistically, RTN3 regulated these events through its interactions with glucose‐regulated protein 78 (GRP78), which further inhibited the adenosine 5 monophosphate‐activated protein kinase (AMPK)–isocitrate dehydrogenase 2 (IDH2) pathway. …”
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57
Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo
Published 2024-01-01“…This classic model however does not translate directly to species that lack a syncytium – such as Caenorhabditis elegans – where cell fate is specified by cell-autonomous cell lineage programs and their inter-signaling. …”
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58
Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i>
Published 2025-01-01“…This study aimed to evaluate the nematocidal effects of L. patula extracts and investigate their impact on germline development, DNA damage responses, and apoptosis in <i>Caenorhabditis elegans (C. elegans</i>), a model organism for studying these processes. …”
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59
Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
Published 2025-02-01“…These stalled complexes triggered synaptic degeneration in a Caenorhabditis elegans model of FAD independently of Aβ production. …”
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60
Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin.
Published 2025-01-01“…We performed a genome-wide association study using a genetically diverse panel of Caenorhabditis elegans strains to identify loci that contribute to resistance to the BZ drug thiabendazole (TBZ). …”
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