Showing 161 - 180 results of 304 for search '"CRISPR"', query time: 0.07s Refine Results
  1. 161

    The necessity of cell banks by A. G. Menzorov, O. L. Serov

    Published 2017-02-01
    “…In addition, a recently developed technology of directed genome modification, CRISPR/Cas, allows correction of genetic mutations in iPSCs. …”
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    Article
  2. 162

    Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

    Published 2025-02-01
    “…Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. …”
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    Article
  3. 163

    Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

    Published 2017-12-01
    “…The new genome editing approaches, such as CRISPR/Cas9, allow us to generate isogenic cell lines that can be useful for drug screening and studying mechanisms of molecular and cellular events triggered by certain mutation on an equal genetic background. …”
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    Article
  4. 164

    A versatile cell line for establishing potency of cell type-specific AAV transgenes by Refugio A. Martinez, Yemeserach M. Bishaw, Meagan A. Quinlan, Erin L. Groce, Bryan B. Gore, Ed S. Lein, John K. Mich, Boaz P. Levi

    Published 2025-03-01
    “…Here, we present the CRISPR activation-AAV receptor (CRAAVR) cell line, a stable HEK293T-derived line that overcomes both problems. …”
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    Article
  5. 165

    Colon Cancer Genetic and Epigenetic Changes, Etiopathogenesis, Risk Factors, Treatment: Literature Review by Gabrielė Ūbaitė, Aurelija Remeikaitė, Justas Žilinskas

    Published 2024-06-01
    “…It highlights the potential of CRISPR/Cas9, immunotherapies, and liquid biopsies in pioneering personalized CRC treatments and early detection. …”
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    Article
  6. 166

    The use of maize haploidy inducers as a tool in agricultural plant biotechnology by A. V. Ulyanov, A. V. Karlov, E. B. Khatefov

    Published 2022-11-01
    “…Thanks to this technology, it became possible to improve haploid inducers by introducing various CRISPR/cas constructs into the haploid inducer genome for editing any DNA site. …”
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    Article
  7. 167

    Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions by Sandip Patil, Xiaowen Chen, Feiqiu Wen

    Published 2024-01-01
    “…Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. …”
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    Article
  8. 168

    GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding by Jiahui Zou, Meijun Jiang, Rong Xiao, Huimin Sun, Hailong Liu, Thomas Peacock, Shaoyu Tu, Tong Chen, Jinli Guo, Yaxin Zhao, Wendy Barclay, Shengsong Xie, Hongbo Zhou

    Published 2025-01-01
    “…In this study, we conduct a comprehensive genome-wide CRISPR/Cas9 knockout screen utilizing EA H1N1 SIV in porcine kidney cells. …”
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    Article
  9. 169

    HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis by Erchen Zhang, Lei Peng, Kejia Yuan, Zexian Ding, Qi Yi

    Published 2025-01-01
    “…Methods: The clustered regularly interspaced short palindromic repeats with CRISPR-associated protein 9 (CRISPR-Cas9) system and overexpression approaches were employed alongside immunofluorescence to investigate the mechanism of ATRX localization at the centromere. …”
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    Article
  10. 170

    THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES by Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini

    Published 2024-08-01
    “…Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding b-globin in defective CD34 cells; more recently, gene editing techniques have been used involving either CRISPR-Cas9, transcription activation-like effector protein nuclease, zinc finger nuclease, and base editing to either induce fetal hemoglobin production at therapeutic levels or to genetically repair the underlying molecular defect causing the disease. …”
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    Article
  11. 171

    Genomic Analysis Methods of Microorganisms by Canan Kebabçıoğlu, Osman Erganiş

    Published 2025-01-01
    “…Sequencing provides genetic data by identifying DNA sequences; Sanger sequencing is the basis for next-generation approaches. CRISPR modifies the genetic code and can correct mutations or control genes using Cas9. …”
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    Article
  12. 172

    Advances in lignocellulosic feedstocks for bioenergy and bioproducts by Daniel B. Sulis, Nathalie Lavoine, Heike Sederoff, Xiao Jiang, Barbara M. Marques, Kai Lan, Carlos Cofre-Vega, Rodolphe Barrangou, Jack P. Wang

    Published 2025-02-01
    “…It also explores emerging biotechnologies such as CRISPR-based genome editing informed by machine learning, aimed at improving feedstock traits and reducing the environmental impact of fossil fuel dependence.…”
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  13. 173
  14. 174
  15. 175

    Biosécurité et surveillance épidémiologique by Valleron, Alain-Jacques

    Published 2024-11-01
    “…Examples are the monitoring of sewer systems and the development of CRISPR tools for detection of biological agents. A new problem is that these tools can be used out of the research laboratories, because they are relatively cheap and easy to develop. …”
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    Article
  16. 176

    A REVIEW ON RECENT ADVANCES IN ANIMAL BIOTECHNOLOGY by Sarada Bhandari, Lokendra Nath Yogi

    Published 2023-09-01
    “…Recent advancements encompass various domains, including genetic editing techniques like CRISPR-Cas9, which allow precise genetic modifications for improved animal health and product quality. …”
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    Article
  17. 177

    A COMPREHENSIVE REVIEW ON-APPLICATION AND FUTURE PROSPECT OF CYTOPLASMIC MALE STERILITY by Sujan Chapagain

    Published 2023-05-01
    “…From the identification of diverse CMS sources to the utilization of advanced genetic engineering techniques like CRISPR-Cas gene editing, the future of CMS in crop breeding appears promising. …”
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    Article
  18. 178

    How data science and AI-based technologies impact genomics by Jing Lin, Kee Yuan Ngiam

    Published 2023-01-01
    “…In this review, we focus on the application of data science and AI technology in three areas, including risk prediction and identification of causal single-nucleotide polymorphisms, EHR-based phenotyping and CRISPR guide RNA design. Additionally, we highlight a few emerging AI technologies, such as transfer learning and multi-view learning, which will or have started to benefit genomic studies.…”
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  19. 179

    Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

    Published 2025-02-01
    “…To improve long-term efficacy, we used CRISPR/CRISPR-associated protein 9-mediated gene editing to ablate the expression of the transcription factor Blimp-1. …”
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    Article
  20. 180

    mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii. by Elisabeth Kravets, Gereon Poschmann, Sebastian Hänsch, Veronica Raba, Stefanie Weidtkamp-Peters, Daniel Degrandi, Kai Stühler, Klaus Pfeffer

    Published 2025-01-01
    “…Furthermore, we could prove the requirement of Gal9 for growth control of T. gondii by CRISPR/Cas9 mediated gene editing. These discoveries clearly indicate that Gal9 is a crucial factor for the mGBP2-coordinated cell-autonomous host defense mechanism against T. gondii.…”
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