Temporal Changes in Phosphatidylserine Expression and Glucose Metabolism after Myocardial Infarction: An in Vivo Imaging Study in Mice by Sebastian Lehner, Andrei Todica, Stefan Brunner, Christopher Uebleis, Hao Wang, Carmen Wängler, Nadja Herbach, Tanja Herrler, Guido Böning, Rüdiger Paul Laubender, Paul Cumming, Ralf Schirrmacher, Wolfgang Franz, Marcus Hacker

“…Annexin- and FDG-PET recordings were obtained in female (C57BL6/N) mice on days 1 to 4 after ligation of the left anterior descending (LAD) artery. [ 68 Ga]annexin A5 uptake (%ID/g) in the LAD artery territory increased from 1.7 ± 1.1 on day 1 to 5.0 ± 3.3 on day 2 and then declined to 2.0 ± 1.4 on day 3 (p = .047 vs day 2) and 1.6 ± 1.4 on day 4 ( p = .014 vs day 2). …”
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Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice by Fernanda S. Oliveira, Natalia B. Carvalho, Dario S. Zamboni, Sergio C. Oliveira

“…Additionally, spleen cells from NOD1-, NOD2-, and Rip2-deficient mice showed unaltered production of IFN-γ compared to C57BL/6 mice. Taken together, this study demonstrates that NOD1, NOD2 and Rip2 are dispensable for the control of B. abortus during in vivo infection.…”
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Effect of a high-fat diet and iron overload on erythropoiesis in mice by Joe Varghese, Jithu James Varghese, Molly Jacob

“…The effects of hyperinsulinemia and/or iron overload on erythroid differentiation are unclear. Methodology: Male C57Bl/6J wild-type (WT) mice were fed a high-fat diet (HFD) (to produce hyperinsulinemia) or a control diet (CD) for varying periods (4–24 weeks). …”
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Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice by Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

“…In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m3 radon for 24 h. …”
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Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without E... by Sumit Bhattacharyya, Leo Feferman, Terry Unterman, Joanne K. Tobacman

“…Major aims were to determine whether exposure to the commonly used food additive carrageenan could induce fasting hyperglycemia and could increase the effects of a high fat diet on glucose intolerance and dyslipidemia. Methods. C57BL/6J mice were exposed to either carrageenan, high fat diet, or the combination of high fat diet and carrageenan, or untreated, for one year. …”
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Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice by Karrie E. Wheatley, Leticia M. Nogueira, Susan N. Perkins, Stephen D. Hursting

“…We tested the hypothesis that obesity reversal by calorie restriction (CR) versus treadmill exercise (EX) differentially modulates adipose gene expression using 48 female C57BL/6 mice administered a diet-induced obesity (DIO) regimen for 8 weeks, then randomized to receive for 8 weeks either: (1) a control (AIN-76A) diet, fed ad libitum (DIO control); (2) a 30% CR regimen; (3) a treadmill EX regimen (with AIN-76A diet fed ad libitum); or (4) continuation of the DIO diet. …”
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Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins by Hu Wei, Jiang Wen-Bing

“…C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. …”
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Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice by Tracy Baynard, Victoria J. Vieira-Potter, Rudy J. Valentine, Jeffrey A. Woods

“…We aimed to determine the effects of 6 wks of exercise on inflammatory markers in mice concomitantly fed either high-fat (HF) or normal chow (NC) diets in young mice. C57BL/6 mice were randomized into (/group) an NC/sedentary (NC/SED), NC/exercise (NC/EX), HF/SED, and HF/EX groups. …”
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Pyrogallol-Phloroglucinol-6, 6-Bieckol Restored Primary Cilia Length, Which Was Decreased by High-Fat Diet in Visceral Adipose Tissue, and Decreased Adipogenesis by Seyeon Oh, Myeongjoo Son, Ji Tae Jang, Chul Hyun Park, Kuk Hui Son, Kyunghee Byun

“…It is known that the cilia length in adipose tissue of the high-fat diet (HFD) animals was shortened and accompanied by increased adipogenesis. Male C57BL/6N mice were randomly divided into groups. The mice group was given the normal fat diet (NFD/saline), HFD mice group for 4 weeks, and then HFD was also treated for the next 4 weeks with saline (HFD/saline), Ecklonia cava extract (HFD/ECE), or pyrogallol-phloroglucinol-6, 6-bieckol, a segment of ECE (HFD/PPB). …”
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The Effect of Gentle Handling on Depressive-Like Behavior in Adult Male Mice: Considerations for Human and Rodent Interactions in the Laboratory by Caroline Neely, Christina Lane, Julio Torres, Jane Flinn

“…This study examined the effects of different handling techniques on depressive-like behavior, measured by the Porsolt forced swim test, in adult C57BL/6J male mice. The same two researchers handled the mice in a gentle, aggressive, or minimal (control) fashion over approximately two weeks prior to testing. …”
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Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation by Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hong

“…Our study investigated that hypertrophy and fibrosis can be induced after being treated with Ang II in cardiomyocytes (H9c2 cells and primary rat cardiomyocytes) and C57BL/6J mice. The anti-inflammatory drug oridonin could effectively attenuate the degree of cardiac remodeling both in vivo and vitro by inhibiting GSDMD, a key protein of intracellular inflammation which can further activate kinds of inflammation factors such as IL-1β and IL-18. …”
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Shielding the Gut: Ghrelin and Ferrostatin-1’s Protective Role Against Sepsis-Induced Intestinal Ferroptosis by Qiliang Hou, Zhimin Dou, Lei Zhu, Bin Li

“…<b>Methods:</b> This study evaluates the therapeutic efficacy of intraperitoneal ghrelin (80 μg/kg) and Ferrostatin-1 (5 mg/kg) using a cecal ligation and puncture (CLP) model in C57BL/6 mice to determine their potential in alleviating sepsis-induced intestinal damage. …”
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Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin by Esben Axelgaard, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen

“…In the present study, we induced diabetes in MBL knockout mice and in wild type C57BL/6J mice by low-dose streptozotocin injection and measured blood glucose and urine albumin-to-creatinine ratio to monitor development of diabetes. …”
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Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus by Maximilian Lenz, Marina Ben Shimon, Thomas Deller, Andreas Vlachos, Nicola Maggio

“…Indeed, single dose intraperitoneal pilocarpine injection (250 mg/kg) in three-month-old male C57BL/6J mice leads to a rapid reduction in hippocampal SP-cluster sizes and numbers (in CA1 stratum radiatum of the dorsal hippocampus; 90 min after injection). …”
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Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4 by Qianjie Yang, Kuangqi Chen, Siyi Chen, Yinhao Wang, Yutong Xia, Jinbo Chen, Ye Shen

“…We exposed human conjunctival epithelial cells and C57BL/6 mice to BL to establish in vitro and in vivo models and identified the responsive genes in mice’s conjunctiva to BL exposure by RNA sequencing transcriptome analysis. …”
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Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury by Honglei Guo, Hongmei Li, Lilu Ling, Yong Gu, Wei Ding

“…In the present study, we investigated the role of ER stress in inflammation-mediated renal injury in Aldo-infused mice. C57BL/6J mice were randomized to receive treatment for 4 weeks as follows: vehicle infusion, Aldo infusion, vehicle infusion plus tauroursodeoxycholic acid (TUDCA), and Aldo infusion plus TUDCA. …”
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miR-224-5p Attenuates Allergic Responses in Mice with Allergic Rhinitis by Modulating the Th1/Th2 Response by Yuxiao Li, Ran An, Mingjin Wu, Jiayan He, Xiaoguang He

“…Human nasal epithelial cells (HNEpCs) were used to establish an AR cell model induced by Der P1, and C57BL/6 mice were used to establish an AR animal model induced by OVA (ovalbumin). …”
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Toll-like receptor 2/6-stimulated HMC-1 mast cells promote keratinocyte migration in wound healing. by Jiyun Kwon, Kyung-Ah Cho, So-Youn Woo

“…Moreover, FSL-1-HMC-1 CM enhanced wound healing in C57BL/6J mice in vivo. Our findings indicated that TLR2/6-stimulated mast cells contributed to skin homeostasis by promoting tryptase-dependent wound healing.…”
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Local inflammation, lethality and cytokine release in mice injected with Bothrops atrox venom by S. F. Barros, I. Friedlanskaia, V. L. Petricevich, T. L. Kipnis

“…We have provided evidence that: (a) lethality of mice to crude Bothrops venom varies according the isogenic strain (A/J > C57Bl/6 > A/Sn > BALB/c > C3H/ HePas > DBA/2 > C3H/He); (b)BALB/c mice (LD50=100.0 μg) were injected i.p. with 50 μg of venom produced IL-6, IL-10, INF-γ, TNF-α and NO in the serum. …”
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Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation by Taketomo Kido, Mitsuhiro Yoneda, Yan Cai, Tsutomu Matsubara, Jerrold M. Ward, Shioko Kimura

“…In ovalbumin- (OVA-) induced airway allergy inflammation model, Scgb3a2−/− mice in mixed background showed a decreased OVA-induced airway inflammation, while six times C57BL/6NCr backcrossed congenic Scgb3a2−/− mice showed a slight exacerbation of OVA-induced airway inflammation as compared to wild-type littermates. …”
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