Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice by Yangwenjie Wang, Yang Xiang, Ruiqi Wang, Xiangning Li, Jianxiong Wang, Siwang Yu, Ying Zhang

“…In the present study, we evaluated the effects of sulforaphane (SFN), a dietary isothiocyanate derived from cruciferous vegetables and a potent Nrf2 activator, on Nrf2-mediated antioxidant defense responses of skeletal muscle induced by exhaustive exercise in HIIT mice. Male C57BL/6J mice were randomly allocated into control group, HIIT group, and HIIT pretreated with SFN (HIIT+SFN) group. …”
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Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes by Flavia Bruna, David Contador, Paulette Conget, Benjamín Erranz, Claudia L. Sossa, Martha L. Arango-Rodríguez

“…Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice. Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant. …”
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Transcriptome analysis of novel B16 melanoma metastatic variants generated by serial intracarotid artery injection by Jenny C. Kienzler, Erick M. Contreras, Janet Treger, Linda M. Liau, Geoffrey C. Owens, Robert M. Prins

“…To investigate brain tropism, we generated new variants of the B16 mouse melanoma model by serially passaging B16 cells through the brain of immune competent syngeneic C57BL/6 mice. Cells were injected into the right carotid artery and recovered from the brain after the mice had reached the study endpoint due to tumor burden, then expanded in vitro and reinjected. …”
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Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice by Haiping Wang, Jing Sun, Zhanjun Jia, Tianxin Yang, Liang Xu, Bing Zhao, Kezhou Yu, Rong Wang

“…The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male C57BL/6 mice were divided to receive DOCA-salt plus OA-NO2 or DOCA-salt plus vehicle and another group received neither DOCA-salt nor OA-NO2 (control group). …”
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Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation by Yunxiang Lv, Mengyuan Dai, Muzi Wang, Fangfang Chen, Rongyu Liu

“…We explored the pharmacological effects of Gal-1 on the progression of allergic airway inflammation and investigated the underlying mechanism. Female C57BL/6 mice were sensitized on day 0 and challenged with ovalbumin (OVA) on days 14-17 to establish an allergic airway inflammation model. …”
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Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice by Ziyi Xiong, Qiling Kong, Juan Hua, Qi Chen, Dandan Wang

“…Methods and results: Forty-eight male C57BL/6 mice were randomly divided into control and experimental groups. …”
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ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-/- Mouse through Promoting M2 Macrophage Polarization by Yong You, Xiaoqing Zhang, Xiao Wang, Dan Yue, Fanxiang Meng, Junfeng Zhu, Yuanyuan Wang, Xun Sun

“…We injected rIL-33 protein to C57/BL6 mouse to explore how IL-33 induces ILC2 proliferation. …”
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A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation by Shuhua Luo, Menglin Tang, Lei Du, Lina Gong, Jin Xu, Youwen Chen, Yabo Wang, Ke Lin, Qi An

“…The right carotid artery and external jugular vein of anesthetized adult male C57BL/6 mice were cannulated to allow blood flow through a 1/32-inch external tube. …”
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Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil by Lawrence Coppey, Alexander Obrosov, Hanna Shevalye, Eric Davidson, William Paradee, Mark A. Yorek

“…Wild-type and transgenic mice on a C57Bl/6J background were divided into three groups. …”
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Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model by Musaad A. Alshammari, Mohammad R. Khan, Fawaz Alasmari, Abdulaziz O. Alshehri, Rizwan Ali, Mohamed Boudjelal, Khalid A. Alhosaini, Abdurahman A. Niazy, Tahani K. Alshammari

“…In this research, we examined the AIS structure in a BTBR T+Itpr3tf/J mouse model (BTBR), a valid model that exhibits behavioral, electrical, and molecular features of autism, and compared this to the C57BL/6J wild-type control mouse. Using Western blot studies and high-resolution confocal microscopy in the prefrontal frontal cortex (PFC), our data indicate disrupted expression of different isoforms of the voltage-gated sodium channels (NaV) at the AIS, whereas other components of AIS such as ankyrin-G and fibroblast growth factor 14 (FGF14) and contactin-associated protein 1 (Caspr) in BTBR were comparable to those in wild-type control mice. …”
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Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota by Kai Kang, Yue Sun, Dan Pan, Bing Chang, Li-Xuan Sang

“…Colitis was induced in C57BL/6 male mice by administration of 1.5% dextran sulfate sodium (DSS), and the mice were intraperitoneally injected with normal saline (NS) or NAM. …”
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Age-Dependent Effects of Butyl Benzyl Phthalate Exposure on Lipid Metabolism and Hepatic Fibrosis in Mice by Min-Seo Park, Seonhwa Hwang, Hyun-Bon Kang, Minjeong Ha, Juyeon Park, So-Youn Park, Yong-Joo Park, Min-Hi Park

“…Young (2-month-old) and aged (20-month-old) male C57BL/6 mice were exposed to BBP through drinking water at a dose of 169 μg/kg/day for 6 and 4 months, respectively. …”
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Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression by Mingyan Chen, Yanfang Zhang, Yangbo Zhao, Kewei Cao, Ruiyan Niu, Dongguang Guo, Zilong Sun

“…For this study, sixty healthy 4-week-old male C57BL/6 N mice were divided randomly into four groups and treated for 28 days with T-2 concentrations of 0, 0.5, 1.0, and 2.0 mg/kg. …”
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PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles by H. Dihazi, K. Schwarze, S. Patschan, G. A. Müller, O. Ritter, M. Zeisberg, D. Patschan

“…AKI was induced in male C57/Bl6N mice (8–12 weeks) by bilateral renal ischemia (IRI-40 minutes). …”
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The composition of peripheral immunocompetent cell subpopulations and cytokine content in the brain structures of mutant Disc1-Q31L mice by M. M. Gevorgyan, S. Ya. Zhanaeva, E. L. Alperina, T. V. Lipina, G. V. Idova

“…This is the first study to examine the immune parameters in Disc1-Q31L mice with a point mutation in the second exon of the DISC1 gene compared to mice of the C57BL/6NCrl strain (WT, wild type). A flow cytometry assay has shown that intact Disc1-Q31L mice differ from the WT strain by an increase in the percentage of CD3+ T cells, CD3+CD4+ Т helper cells and CD3+CD4+CD25+ T regulatory cells and a decrease in CD3+CD8+ T cytotoxic/suppressor cells in the peripheral blood. …”
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Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina by Ling-Dan Dong, Jie Chen, Fang Li, Feng Gao, Jihong Wu, Yanying Miao, Zhongfeng Wang

“…The protein levels of NR1 and NR2A subunits in retinas of DBA/2J mice at all ages (6–12 months) were not different from those in age-matched C57BL/6 mice. In contrast, the protein levels of NR2B subunits, in addition to age-dependent change, significantly increased with elevated intraocular pressure (IOP) in DBA/2J mice at 6 and 9 months as compared with age-matched controls. …”
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Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling by Jun Wang, Yongzheng Liu, Changhui Ma, Yue Zhang, Meng Yuan, Guangping Li

“…This study is aimed at investigating the impact of the glucagon-like peptide-1 (GLP-1) receptor agonist, Liraglutide (Lir), on atrial remodeling (AR) mouse model induced by chronic intermittent hypoxia (CIH). C57BL/6 mice were categorized randomly into the control, Lir, CIH, and CIH+Lir groups. …”
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A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies by Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy, Bo Porse, Kirsten Grønbæk

“…We established a non-conditioned BMT model using C57BL/6J-Kit W-41J /J (W41) recipient mice to overcome the unwanted effects of irradiation. …”
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Effects of defined voluntary running distances coupled with high‐fat diet consumption on the skeletal muscle transcriptome of male mice by Afrina Brishti, Sarah J. Johnson, Daniel G. Palmer, Md Obayed Raihan, Lin Yan, Shanon L. Casperson

“…We investigated the interplay between diverse exercise regimes and HFD consumption on the adaptation of skeletal muscle transcriptome. C57BL/6 male mice were randomized into five groups—one sedentary control group and four exercise groups. …”
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Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…Acute renal injury was established in adult female C57BL/6 mice with 20mg/kg, i.p. single dose cisplatin. …”
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