TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. C57BL/6 mice received 105 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. …”
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Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function by Shubhnita Singh, Ariane Bruder, Rafael M. Costa, Juliano V. Alves, Sivakama Bharathi, Eric S. Goetzman, Thiago Bruder‐Nascimento

“…Methods and Results We used aortae from male and female C57BL6/J wild‐type (PGRN+/+) and B6(Cg)‐Grntm1.1Aidi/J (PGRN−/−) mice. …”
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Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics by Ilias Doulamis, Despina N. Perrea, Panagiotis E. Chatzistergos, Athanasios S. Mitousoudis, Stavros K. Kourkoulis

“…A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). …”
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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Results Our findings demonstrated significant variations in the recorded phenotypes across different CC lines compared to the reference mouse line, C57BL/6J. CC037 line exhibited a substantial increase in body weight on HFD, whereas line CC005 exhibited differing responses based on sex. …”
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PTPIP51: A New Interaction Partner of the Insulin Receptor and PKA in Adipose Tissue by M. A. Bobrich, S. A. Schwabe, A. Brobeil, M. Viard, M. Kamm, F. C. Mooren, K. Krüger, C. Tag, M. Wimmer

“…Methods. Four groups of ten C57Bl/6 mice each were used. Two groups were fed a standard diet; two groups were fed a high-fat diet. …”
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Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway by Linhua Lv, Qiuhuan Kong, Zhiying Li, Ying Zhang, Bijiao Chen, Lihua Lv, Yubi Zhang

“…Methods. Seventy-eight male C57BL/6 mice were categorized randomly into three cohorts including the Sham operation (Sham) cohort, the MI/RI cohort (Con), and the Honokiol cohort (n=26 for each cohort). …”
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…After the model was performed, C57BL/6J mice received topical treatment with saline eye drops or pranoprofen eye drops and were, respectively, categorized as saline group and pranoprofen group, whereas the remaining normal mice that were not subjected to alkali burns served as control, each group containing 15 mice (n = 45). …”
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Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice by Masaru Yamaguchi, Khin Thandar Htun, Youta Tatara, Yoshiaki Sato, Masato Hosoda, Suchart Kothan, Chikashi Kamimura, Osamu Inanami, Ikuo Kashiwakura

“…In this study, female C57BL/6J mice given ad libitum access to ultra-fine bubble hydrogen water (UBHW) were subjected to whole-body irradiation (WBI) with X-rays, and the radio-protective effect of UBHW was evaluated. …”
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Mesenchymal Stem Cells Enhance Pulmonary Antimicrobial Immunity and Prevent Following Bacterial Infection by Wenchao Li, Weiwei Chen, Saisai Huang, Xiaojun Tang, Genhong Yao, Lingyun Sun

“…Methods. In this study, C57BL/6 mice were treated with either CTX or MSCs, and then both the innate and adaptive immunity of the lung were determined. …”
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Cryopreservation of Bone Marrow Mononuclear Cells Alters Their Viability and Subpopulation Composition but Not Their Treatment Effects in a Rodent Stroke Model by Bing Yang, Kaushik Parsha, Krystal Schaar, Nikunj Satani, Xiaopei Xi, Jaroslaw Aronowski, Sean I. Savitz

“…In the present study, C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAo) for 60 minutes and then divided into two treatment groups: fresh MNCs versus cryopreserved MNCs. …”
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Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice by Md Imam Faizan, Gagandeep Kaur, Sadiya Bi Shaikh, Felix Effah, Hoshang Unwalla, Irfan Rahman

“…In contrast, the J:DO strain, characterized by genetic outbreeding, showed a much more robust lung macrophage response comparable to C57BL/6J. The findings provide valuable insight into how genetic diversity affects immune responses in response to acute CS/ETS exposure, with implications for understanding diverse human responses to environmental stressors in studying lung pathophysiology.…”
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Antitumor effect of a pyrazolone-based-complex [Cu(PMPP-SAL)(EtOH)] against murine melanoma B16 cell in vitro and in vivo by Abula Ayipairi, Zhao Jing, Xu Guancheng, Li Yijie, Sun Surong

“…B16 cell apoptosis was significantly higher in comparison to the control group (DMSO) (p < 0.01), and cell cycle arrest occurred at the G0/G1 phase. When challenged C57 BL/6J mice were treated with [Cu(PMPPSAL)(EtOH)], a smaller volume of B16 solid tumors were reported than the control group (p < 0.01), with lower positive expression indices of CD 34, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) (p < 0.01). …”
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IL-18 Blockage Reduces Neuroinflammation and Promotes Functional Recovery in a Mouse Model of Spinal Cord Injury by Easmin Begum, Md Rashel Mahmod, Md Mahbobur Rahman, Fumiko Fukuma, Takeshi Urano, Yuki Fujita

“…In a mouse model of SCI (C57BL/6J strain), mice were administered 150 μg of the anti-IL-18 antibody intraperitoneally. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Mechanical force-induced HSs were generated in C57BL6/J mice by suturing a dorsal incision and applying a stretching device on Days 6, 8, 10, and 12. …”
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Peripheral Blood DNA Methylation Changes in Response to <i>Centella asiatica</i> Treatment in Aged Mice by Olivia Monestime, Brett A. Davis, Cora Layman, Kandace J. Wheeler, Wyatt Hack, Jonathan A. Zweig, Amala Soumyanath, Lucia Carbone, Nora E. Gray

“…Eighteen-month-old mice were treated with CAW in their drinking water for 5 weeks alongside vehicle-treated eighteen-month-old C57BL6 mice. Reduced representation bisulfite sequencing (RRBS) was used to identify genome-wide differential methylation in the blood of CAW-treated aged mice compared to vehicle-treated aged mice. …”
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Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis by Munkhtugs Davaatseren, Jin-Taek Hwang, Jae Ho Park, Myung-Sunny Kim, Shuaiyu Wang, Mi Jeong Sung

“…Experimental colitis was induced in male C57BL/6 mice by administering 3% DSS. Disease activity index (DAI), histopathological scores, microvascular density, myeloperoxidase activity, and VEGF-A and VEGFR2 expression were compared among control mice, DSS-treated mice, and mice receiving 3% DSS along with γ-PGA at 50 mg/kg body weight per day or 3% DSS with γ-PGA at 200 mg/kg body weight per day. …”
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Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation by Shuxiao Chen, Xiaotian Liu, Xincheng Zhou, Weixiao Lin, Minting Liu, Haoran Ma, Keli Zhong, Qiming Ma, Chengjian Qin, Chengjian Qin

“…The purpose of this study is to investigate the role of ATL-I in the progression of AAA.MethodsAAA was constructed in C57BL/6 mice by porcine pancreatic elastase (PPE)-incubation, and the diameter of the aorta was measured by ultrasound. …”
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Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice by Dong Han, Jue Wang, Lulu Wen, Miao Sun, Hang Liu, Yan Gao

“…We carried out middle cerebral artery occlusion/reperfusion (MCAO/R) surgery on C57BL/6 male mice. RIPC was generated by 10-minute occlusion followed by the same period of reperfusion of the bilateral hind limb femoral artery and repeated for 3 cycles. …”
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Time-Restricted Feeding Reinforces Gut Rhythmicity by Restoring Rhythms in Intestinal Metabolism in a Jetlag Mouse ModelSummary by Hui Leng, Theo Thijs, Louis Desmet, Guillaume Vanotti, Mona Farhadipour, Inge Depoortere

“…Enteroids from Bmal1+/+ and Bmal1-/- mice were used to replicate the processes that were affected by chronic jetlag and rescued by TRF. Methods: C57BL/6J male mice were subjected to chronic jetlag or night-TRF for 4 weeks. …”
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Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness by Qiufang Ouyang, Ziyang Huang, Zhenhua Wang, Xiaoqing Chen, Jingqin Ni, Ling Lin

“…We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. …”
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