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461
Distributed Cooperative Search Control Method of Multiple UAVs for Moving Target
Published 2015-01-01“…The simulation results have verified that the proposed method can avoid the blindness of UAV searching better and improve overall efficiency of the team effectively.…”
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462
Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy
Published 2012-01-01“…Diabetic retinopathy (DR) is the major cause of acquired blindness in working-age adults. Current treatments for DR (laser photocoagulation, intravitreal corticosteroids, intravitreal antivascular endothelial growth factor (VEGF) agents, and vitreo-retinal surgery) are applicable only at advanced stages of the disease and are associated with significant adverse effects. …”
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463
The Genetic Basis of Congenital Cataracts: Advances in Diagnostics and Therapeutics
Published 2025-02-01“… Congenital cataracts, a significant cause of childhood blindness, result from genetic mutations, syndromic associations, and environmental factors, with autosomal dominant inheritance and mutations in genes like CRYAA and GJA8 being prevalent. …”
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464
Use of biologic response modifiers for the management of ocular inflammatory conditions
Published 2018-01-01“…We review and discuss, (1) a 60-year-old male with granulomatosis with polyangiitis and bilateral anterior scleritis who required rituximab; (2) a 25-year-old male with refractory, idiopathic, bilateral chronic panuveitis and retinal vasculitis, which was controlled with adalimumab after treatment failure with oral and topical corticosteroids, cyclosporine, and methotrexate; and (3) a 44-year-old female with unilateral blindness and juvenile psoriatic arthritis-related intermediate uveitis, who required adalimumab to control her complication of persistent macular edema. …”
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465
Leukocyte Adhesion Molecules in Diabetic Retinopathy
Published 2012-01-01“…One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms underlying the development of DR are not fully understood; however, extensive studies have recently implicated chronic, low-grade inflammation in the pathophysiology of DR. …”
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466
Leber hereditary optic neuropathy
Published 2018-12-01“…LHON is associated with severe, subacute, and painless bilateral vision loss and accounts for one of the most common causes of legal blindness in young individuals. Spontaneous visual acuity recovery has been reported in patients harbouring m.14484T>C mutation, however, this inherited optic neuropathy results in irreversible vision loss. …”
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467
Advances in Research Related to MicroRNA for Diabetic Retinopathy
Published 2024-01-01“…Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. …”
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468
Anton’s Syndrome due to Bilateral Ischemic Occipital Lobe Strokes
Published 2014-01-01“…Bilateral occipital brain damage results in blindness, and patients start to confabulate to fill in the missing sensory input. …”
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469
SCRD-Net: A Deep Convolutional Neural Network Model for Glaucoma Detection in Retina Tomography
Published 2021-01-01“…Early and accurate diagnosis of glaucoma is critical for avoiding human vision deterioration and preventing blindness. A deep-neural-network model has been developed for the diagnosis of glaucoma based on Heidelberg retina tomography (HRT), called “Seeking Common Features and Reserving Differences Net” (SCRD-Net) to make full use of the HRT data. …”
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470
Nephronophthisis: A Genetically Diverse Ciliopathy
Published 2011-01-01“…The most frequent extrarenal association is retinal degeneration, leading to blindness. Increasingly, molecular genetic testing is being utilised to diagnose NPHP and avoid the need for a renal biopsy. …”
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471
Varicella Zoster Meningitis, Optic Neuritis Preceding the Development of Posterior Outer Retinal Necrosis, and Central Retinal Artery Occlusion in a HIV Patient
Published 2019-01-01“…Four weeks after discharge, she presented with sudden onset blindness in the left eye. A cerebral angiogram revealed left retinal artery occlusion and was treated with tissue plasminogen activator (tPA). …”
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472
Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis
Published 2022-01-01“…Diabetic macular edema (DME) is the main cause of blindness in individuals with diabetes mellitus (DM). …”
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473
Antivascular Endothelial Growth Factor Agents for Neovascular Age-Related Macular Degeneration
Published 2012-01-01“…Age-related macular degeneration (AMD) is the leading cause of severe visual loss and blindness over the age of 50 in developed countries. …”
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474
Methamphetamine Use: A Narrative Review of Adverse Effects and Related Toxicities
Published 2022-09-01“…It can also cause cerebral vasculitis, which elicits cortical blindness and ischemic strokes. Methamphetamine-induced neurotoxicity in serotonergic systems is more diffuse, involving the striatum, hippocampus, septum, amygdala, and hypothalamus leading to mood changes, psychosis, and memory impairment. …”
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475
Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy.
Published 2025-01-01“…Traumatic optic neuropathy (TON) is a common cause of irreversible blindness following head injury. TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. …”
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476
Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration
Published 2019-01-01“…Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. …”
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477
Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton
Published 2015-01-01“…Patients typically displayed spontaneous fractures, anemia, and in the most severe forms hepatosplenomegaly and compression of cranial facial nerves leading to deafness and blindness. Osteopetrosis comprises a heterogeneous group of diseases as several forms are known with different models of inheritance and severity from asymptomatic to lethal. …”
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478
Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside
Published 2011-01-01“…While the mutated mtDNA impairs generation of ATP by all mitochondria, there is only a selective loss of retinal ganglion cells and degeneration of optic nerve axons. Thus, blindness is typically permanent. Half of the men and 10% of females who harbor the pathogenic mtDNA mutation actually develop the phenotype. …”
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479
Animal Models of Diabetic Retinopathy: Summary and Comparison
Published 2013-01-01“…Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. …”
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480
Non-Viral Delivery Systems to Transport Nucleic Acids for Inherited Retinal Disorders
Published 2025-01-01“…Inherited retinal disorders (IRDs) represent a group of challenging genetic conditions that often lead to severe visual impairment or blindness. The complexity of these disorders, arising from their diverse genetic causes and the unique structural and functional aspects of retinal cells, has made developing effective treatments particularly challenging. …”
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