Efficacy and safety of glycyrrhizic acid combined to essential phospholipids (Phosphogliv) at non-alcoholic fatty liver disease: results of multicenter double blind randomized placebo-controlled post-registration clinical study (IV phase) «Gepard» (PHG-M2/P02-12) by V. T. Ivashkin, I. G. Bakulin, P. O. Bogomolov, M. V. Matsiyevich, N. I. Geyvandova, P. V. Koroy, S. V. Nedogoda, O. A. Sablin, L. G. Lenskaya, Ye. V. Beloborodova, A. A. Bagretsova, R. A. Abdulkhakov, M. F. Osipenko, I. V. Osipova, D. A. Pocheptsov, Ye. V. Chumachek, O. M. Khromtsova, Ye. V. Kuzmicheva

Get full text

Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the ‘EEG in General Anaesthesia - More Than Only a Bispectral Index’ Trial, a multicentre, double-blind, randomised controlled trial by Luzius A Steiner, Salome Dell-Kuster, Bettina U Gruber, Valerie Girsberger, Lukas Kusstatscher, Simon Funk, Anita Luethy, Lien Jakus, Julien Maillard, Christoph S Burkhart

“…We hypothesise that quality of recovery (QoR) in patients undergoing laparoscopic surgery is better, if propofol is titrated by anaesthesia practitioners able to interpret the EEG.Methods and analysis This is a multicentre, double-blind (patients and outcome assessors) randomised controlled trial taking place in four Swiss hospitals. …”
Get full text

Research on Density Peak Clustering Color-Separation Algorithm Based on SOM Neural Network by Xin Ru, Yanhao Wang, Ran Chen, Zhifa Zeng, Laihu Peng, Wei Tang, Weimin Shi, Hui Wang

Subjects: Get full text

Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2) by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Here, we summarise an ethically approved protocol for a double-blind, randomised controlled trial investigating the effect of the 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPV23) on pneumococcal nasopharyngeal colonisation acquisition, density and duration using experimental human pneumococcal challenge (EHPC).Methods and analysis Healthy adult participants aged 18–50 years will be randomised to receive PCV13, PPV23 or placebo and then undergo one or two EHPCs involving intranasal administration of SPN at 1-month post-vaccination with serotype 3 (SPN3) and 6 months with serotype 6B (SPN6B). …”
Get full text

Investigation of the effects of combined exercises and self-management education, with and without functional exercises, on pain and functional outcomes in patients with avascular necrosis of the femoral head: a protocol for a single-blind, randomised controlled trial with a parallel design and a 4 month follow-up by Zohreh Gholami, Seyedeh Tahereh Faezi, Elham Madreseh, Raghad Mimar

Get full text

Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protocol for a Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase Ia/b Clinical Trial by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Methods: In a multi-center, randomized, double-blind, and placebo-controlled dose-escalation phase Ia/b trial, the safety, tolerability, and immunogenicity of three intramuscular vaccinations administered 4 weeks apart with 2.5 µg or 10 µg of Invaplex_AR-Detox vaccine, alone or in combination with 0.1 µg of the dmLT adjuvant, will first be assessed in a total of 50 healthy Dutch adults (phase Ia) and subsequently in 35 healthy Zambian adults (phase Ib) aged 18–50 years. …”
Get full text

Access to electronic resources by visually impaired people by Jenny Craven

Subjects: Get full text

The Taking Charge After Stroke (TaCAS) study protocol: a multicentre, investigator-blinded, randomised controlled trial comparing the effect of a single Take Charge session, two Take Charge sessions and control intervention on health-related quality of life 12 months after stroke for non-Māori, non-Pacific adult New Zealanders discharged to community living by Mark Weatherall, Harry McNaughton, Vivian Wai Yin Fu

“…However, there is limited information on the generalisability and optimum dose of these interventions.Methods The Taking Charge After Stroke (TaCAS) study is a multicentre, investigator-blinded, randomised controlled trial recruiting 400 participants following acute stroke from seven hospitals in New Zealand. …”
Get full text

The Prevalence and Causes of Visual Impairment in Type 2 Diabetes Mellitus in Northeast China by Liang Wen, Yu Wang, Zhong Lin, Feng Hua Wang, Xiao Xia Ding, Dong Li, Kemi Feng, Yuan Bo Liang, Dong Xiao Zhang, Yu Dou, Gang Zhai

“…The primary causes of blindness and low vision were assessed by senior ophthalmologists. …”
Get full text

Intravitreal Ampicillin Sodium for Antibiotic-Resistant Endophthalmitis: Streptococcus uberis First Human Intraocular Infection Report by Raul Velez-Montoya, Dulce Rascón-Vargas, William F. Mieler, Jans Fromow-Guerra, Virgilio Morales-Cantón

Get full text

Prevalence, Risk Factors, and Causes of Visual Impairment in an Elderly Chinese Uygur Population in Southern Xinjiang by Yi Sun, Guangming Jin, Mengting Yang, Jing Fu, Xueyi Chen, Bingsheng Lou

“…Cataract is the leading cause of low vision and blindness.…”
Get full text

Anterior Segment Findings in Vitamin A Deficiency: A Case Series by Pierangela Rubino, Paolo Mora, Nicola Ungaro, Stefano A. Gandolfi, Jelka G. Orsoni

“…Vitamin A deficiency is a rare but vision threatening disorder in the developed world, which can lead to blindness for severe keratomalacia with cornea scarring and perforation or night blindness due to impaired dark adaptation. …”
Get full text

The Nonmydriatic Fundus Camera in Diabetic Retinopathy Screening: A Cost-Effective Study with Evaluation for Future Large-Scale Application by Giuseppe Scarpa, Francesca Urban, Stela Vujosevic, Michele Tessarin, Giovanni Gallo, Annalisa Visentin, Emanuela Foglia, Lucrezia Ferrario, Edoardo Midena

“…Fundus images obtained with a nonmydriatic fundus camera could be considered an effective, cost-sparing, and feasible screening tool for the early detection of DR, preventing blindness as a result of diabetes.…”
Get full text

Visual impairment prevention by early detection of diabetic retinopathy based on stacked auto-encoder by Shagufta Almas, Fazli Wahid, Sikandar Ali, Ahmed Alkhyyat, Kamran Ullah, Jawad Khan, Youngmoon Lee

“…Abstract Diabetic retinopathy (DR) presents a significant concern among diabetic patients, often leading to vision impairment or blindness if left untreated. Traditional diagnosis methods are prone to human error, necessitating accurate alternatives. …”
Get full text

Reducing the risk of visual disability for children with juvenile idiopathic arthritis uveitis through disease surveillance: past and future challenges by Ameenat Lola Solebo, Ivan Foeldvari

“…Abstract Childhood blindness significantly impacts development, education, employment, and mental health, creating burden for families and society. …”
Get full text

Uveitis associated with elevation of intraocular pressure – what is the optimal therapy? by Agnieszka Kubicka-Trząska

“…Uveitis is the fifth leading cause of blindness in developed countries. The ocular complications of uveitis are not only related to the inflammation itself but also result from glucocorticosteroid therapy, which is the mainstay of treatment. …”
Get full text

Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model by Yuanyuan Zhang, Kewei Tian, Hong Jiang, Beibei Wang, Shu Han

“…In conclusion, our study suggests a possible treatment that can relieve progressive blindness and paralysis in an animal model of NMO through improvement of the inflammatory milieu.…”
Get full text

Comparison of Fully Convolutional Networks and U-Net for Optic Disc and Optic Cup Segmentation by Jin Zixiao

“…Glaucoma, the leading cause of irreversible blindness, must be diagnosed early and thus treated in time. …”
Get full text

Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy by Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Mohammad Sharifzadeh, Ahmad Reza Dehpour

“…Abstract Onchocerciasis, commonly known as river blindness, is a neglected tropical disease caused by the parasite Onchocerca volvulus. …”
Get full text

A 5-Year Retrospective Review of Fungal Keratitis at Hospital Universiti Sains Malaysia by Fadzillah Mohd-Tahir, A. Norhayati, Ishak Siti-Raihan, M. Ibrahim

“…Background. Corneal blindness from healed infected keratitis is one of the most preventable causes of monocular blindness in developing countries, including Malaysia. …”
Get full text