Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

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Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

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Factors affecting the implementation of guideline-based prophylactic antiemetic therapy for chemotherapy-induced nausea and vomiting in Japan: a protocol for a hospital-based quali... by Yosuke Uchitomi, Junko Saito, Maiko Fujimori, Taichi Shimazu, Ayako Okuyama, Sadamoto Zenda, Ayumu Matsuoka, Akiko Yaguchi-Saito, Yuki Kaji, Miyuki Odawara, Aki Otsuki

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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

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Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

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Telehealth and patient satisfaction: a systematic review and narrative analysis by Clemens Scott Kruse, Nicole Krowski, Blanca Rodriguez, Lan Tran, Jackeline Vela, Matthew Brooks

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Ethnic differences between South Asians and white Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review protocol by Olalekan Abdulrahman Uthman, Mubarak Patel, Salim Abatcha

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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

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Innovative models of healthcare delivery: an umbrella review of reviews by Frances Rapport, Jeffrey Braithwaite, Yvonne Zurynski, Peter D Hibbert, Kate Churruca, Louise A Ellis, Chiara Pomare, Robyn Clay-Williams, Stephanie Best, Janet C Long, Gaston Arnolda, Bróna Nic Giolla Easpaig, Zeyad Mahmoud, Mitchell N Sarkies, Hoa Mi Nguyen, Karen Hutchinson, Gilbert Thomas Knaggs, Katherine Maka, Elizabeth E Austin, Diana Fajardo Pulido, Sarah Hatem, Natalie Roberts, Emilie Francis Auton, Genevieve Dammery, Isabelle Meulenbroeks, Ann Carrigan, Mai-Tran Nguyen

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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

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Information needs and mHealth applications for carers of people with dementia in managing behavioural and psychological symptoms of care recipients: an integrative review protocol by Samath Dharmaratne, Thilanka Jagoda, Sarath Rathnayake

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Ethical challenges in palliative sedation of adults: protocol for a systematic review of current clinical practice guidelines by Cécile Jaques, Ralf J Jox, Martyna Tomczyk

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BIOSKIN: A Protocol for the Copenhagen Translational Skin Immunology Biobank and Research Programme by Lone Skov, Jeanne Duus Johansen, Marianne Bengtson Løvendorf

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Determinants of subjective well-being among migrant and local elderly in China: a cross-sectional study by Chonghua Wan, Rassamee Sangthong, Liu Yuxi, Thammasin Ingviya

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Stress dynamics between clinical supervisors and allied health students: a scoping review protocol by Yongsheng Wang, XinRong Li, Piao Wang, Laurie Peebles, Aine O'Connor

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Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies by Huaqing Zheng, Changhong Chen

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Understanding patient views and experiences of the IDENTIfication of PALLiative care needs (IDENTI-Pall): a qualitative interview study protocol by Sarah Mitchell, Isabel Leach, Nicola Turner, C R Mayland

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Effect of traditional Chinese exercise on abnormal lipid metabolism in patients with atherosclerosis: a protocol for meta-analysis of randomised controlled trials by Chen Wang, Peizhen Zhang, Yuting Yang

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Why do patients with ‘primary care sensitive’ problems access ambulance services? A systematic mapping review of the literature by Ali R G Shaw, Sarah Purdy, Matthew J Booker

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