Development of Novel Fluticasone/Salmeterol/Tiotropium-Loaded Dry Powder Inhaler and Bioequivalence Assessment to Commercial Products in Rats by Hyukjun Cho, Hyunji Lee, Duhyeong Hwang

“…Furthermore, micronized FP/SX/TB-loaded DPI exhibited bioequivalence to commercial products, as evidenced by no significant differences in pharmacokinetic parameters following intratracheal administration in rats. <b>Conclusions</b>: A novel triple-combination DPI containing FP/SX/TB was successfully developed, demonstrating comparable pharmacological performance to commercial products. …”
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Direct-Acting Antivirals in Hepatitis C Treatment for Renal Impairment: Liver Safety Concerns and Effectiveness in Peritoneal Dialysis by Hsuan-Yu Hung, Wei-Liang Hung, Ye Gu, Chung-Yu Chen

“…This study investigates the association between renal failure and DILI, using real-world data, and assesses the effectiveness of these treatments in peritoneal dialysis patients. <b>Methods:</b> A retrospective cohort study was conducted using data from the Ditmanson Research Database, including patients with CHC treated with G/P or EBR/GZR from 1 August 2017 to 31 December 2020. …”
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Reexamination In Vitro and In Situ of an Antibacterially Modified Experimental Dental Resin Composite with Molecular Methods: A Pilot Study by Birgit Henrich, Ilka Hermann, Mara Di Giulio, Karl Köhrer, René Deenen, Sugi Sivalingam, Ulrike Peters, Thomas Beikler, Ralf Janda, Stefan Rüttermann

“…Initial biofilm formation was altered by B. A shift between actinomycetes and streptococci was observed in situ. …”
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Versatile High-Throughput Platform for Focused Ultrasound In Vitro Application by Steffen H. Tretbar, Marc Fournelle, Christian Degel, Franz-Josef Becker, Peter Weber, Sarah Therre-Mohr, Wolfgang Bost, Lisa Landgraf, Andreas Melzer

“…Two different platform configurations were developed: (a) a low-intensity version with 96 individual transducers allowing dry coupling of the well plate; and (b) a high-intensity version with water cooling, supporting parallel sonication of 32 out of 96 wells. …”
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The Comparison Of The Success Rates Of The Prostaglandin E2 (PGE2) Versus Foley Catheter In Females With Postdate Pregnancy by Qamarunissa Muhabat Khan, Khadija Mastoor, Amna Javaid, Tahira Raza, Sadia Ilyas, Safoora Anjum

“…The study findings revealed that success was attained by 30(34.4%) individuals in group A and 57(65.5%) in group B. A statistically significant difference was observed between groups regarding the success of patients. i.e., p-value (<0.05) Conclusion: A study concludes that Prostaglandin E2 (PGE2) showed significantly higher success rates for achieving vaginal delivery within 24.0 hours when compared to Foley catheters in female individuals with postdate pregnancies. …”
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The Effects of Garlic and Red Chilli Pepper Powder on Physicochemical, Microbiological, and Sensory Properties of Cincalok by Risa Nofiani, Novi Maulidi Syahmurdiandi, Puji Ardiningsih

“…Cincalok was made to be three recipes, namely, original cincalok, A, consists of 2 kg of rebon shrimp, 400 g of granulated sugar, and 100 g of coarse salt; B (A ingredients plus 20 g of red chilli pepper powder); and C (A ingredients plus 20 g of garlic powder). …”
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Comparative assessment of plasticity, stability and homeostasis based on ‘1000 grain weight’ in winter rye cultivars developed at VIR by N. I. Aniskov, I. V. Safonova

“…Data processing was performed using the analysis of variance according to B. A. Dospekhov. Adaptability and stability levels were calculated using the methods by S. …”
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Rotavirus Vaccination Protects Against Diabetes Mellitus Type 1 in Children in Developed Countries: A Systematic Review and Meta-Analysis by Chrysoula Kosmeri, Achilleas Klapas, Nikolas Evripidou, Evanthia Kantza, Anastasios Serbis, Ekaterini Siomou, Fani Ladomenou

“…The analysis pooled hazard ratios (HRs) from selected studies using a fixed-effects model, with statistical significance set at <i>p</i> < 0.05 and heterogeneity evaluated using the I² statistic. <b>Results</b>: A systematic search identified 90 records, of which 5 studies met the inclusion criteria. …”
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Calidad higiénico-sanitaria de dos sistemas de ordeño en fincas bovinas ubicadas en el sector Vuelta Larga, municipio Maturín, estado Monagas (Venezuela) by B. Guevara, M. C. Rivas, R. Silva-Acuña

“…Adicionalmente, se determinó la población de bacterias aerobias mesófilas (BAM) que se cuantificaron en un experimento en bloques al azar, con arreglo factorial de los tratamientos (2x2) donde el factor A, correspondió al sistema de ordeño manual y mecánico y el factor B, a la aplicación y omisión de secado de los pezones de cada animal previo al ordeño. …”
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Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review by Jakub Fiegler-Rudol, Natalia Zięba, Radosław Turski, Maciej Misiołek, Rafał Wiench

“…Inclusion criteria encompassed preclinical in vitro and in vivo studies and clinical trials focusing on HY-PDT for head and neck malignancies and its subtypes. <b>Results</b>: A total of 13 studies met the inclusion criteria, comprising both in vitro and in vivo investigations. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Here, we report a method of targeted immunotherapy using an attenuated Salmonella typhimurium (SAM-FC) engineered to release dual payloads: cytolysin A (ClyA), a cytolytic anti-cancer agent, and Vibrio vulnificus flagellin B (FlaB), a potent inducer of anti-tumor innate immunity. …”
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Factors Associated with Adherence to Diabetic Retinopathy Screening Among Patients Attending a Nurse-Led Community Clinic in Australia: A Qualitative Study by Fouziah Almouqati, Judith Daire, Catherine Catanach, Jean-Louis deSousa, Sam Quill, Mohamed Estai

“…The interview data were analyzed thematically using NVivo based on the socio-ecological model, with salience identified by the frequency of the theme. <b>Results:</b> A total of 22 participants completed the interview, including 10 females with a mean age of 60 ± 16.2 years. …”
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Long-Haul COVID: Investigating the Effects Within the Mauritian Context by Aïsha B. Soreefan, Manish Putteeraj, Jhoti Somanah

“…<b>Research Setting:</b> A cross-sectional study was performed using an adapted online questionnaire, using two definitions of Long COVID, namely the WHO and NICE, SIGN and RCGP definitions. …”
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Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD by Wei Du, Xiao-Wei Wu, Qing-Feng Li, Bing-Yu Zhang, Jing Wu, Ya-Ping Xu, Xue Yi

“…Chromosomal assembly factor 1B (CHAF1B), a p60 component of the CAF-1 complex, is closely linked to tumor incidence and cell proliferation. …”
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Xanthomonas citri subsp. citri requires a genus-specific outer membrane protein and TolB to coordinate cell membrane integrity and virulence by Leilei Wu, Xueyan Zhu, Hang Long, Xinyu Huang, Shuying Zhu, Qi Xue, Ziao Li, Huasong Zou

“…Pull-down and yeast two-hybrid assays revealed that OMPXan interacts with TolB, a substrate of the Tol/Pal membrane protein system. …”
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Controversies in the Application of AI in Radiology—Is There Medico-Legal Support? Aspects from Romanian Practice by Ana-Maria Ungureanu, Sergiu-Ciprian Matei, Daniel Malita

“…This narrative review manuscript analyzes the existing literature data regarding the medico-legal aspects of AI application in radiology, highlighting the controversial aspects and the lack of statutory legislative regulations in Romania. <b>Methods</b>: A detailed search was conducted across three electronic databases including MEDLINE/PubMed, Scopus, and Web of Science, with 53 papers serving as the literature corpus of our review. …”
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Investigations of Long-Acting Formulations in Children, Adolescents, and Pregnant Women: A Systematic Review by Lynn Bertagnolli, Zhengyi Deng, Melissa Davy-Rothwell, Elaine J. Abrams, Charles Flexner, Ethel D. Weld

“…After abstract review and duplication removal, full-text articles were obtained for further review, reviewed by two independent reviewers, and disagreements were resolved by a third reviewer. <b>Results:</b> a total of 101 studies of long-acting therapeutics were completed in these populations, and most (80%) of these had a sample size of <100 individuals. …”
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Concept, features and types of corruption by L. I. Kalienichenko, D. V. Slynko

“…The main features of corruption: 1) committed by a special subject of law; 2) is performed within the scope of official authority or related opportunities; 4) is committed for the purpose of obtaining illegal benefit for oneself or other persons; 5) is committed in a certain form (the legislator establishes two forms of corruption: a) acceptance of illegal benefit or acceptance of a promise / proposal of illegal benefit; b) a promise / proposal or provision of illegal benefit to a person specified in Part 1 of Art. 3 of the Law of Ukraine “On Prevention of Corruption”); 6) the result is improper performance of duties. …”
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Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy by Esra Kızıldağ Özbay, Şenol Sabancı, Mehmet Fatih Küçük, Muhammet Kazım Erol

“…<b>Background:</b> This study aims to evaluate the quantitative changes in retinal nerve fiber layer (RNFL) thickness and radial peripapillary capillary (RPC) vessel density in patients with chronic central serous chorioretinopathy (CSCR), specifically excluding the peripapillary region. <b>Methods:</b> A prospective case–control study was conducted at the Antalya Training and Research Hospital, Health Sciences University, involving 65 patients with chronic CSCR. …”
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Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis by Lie Huang, Juan Fan, Yan-Xiang Chen, Jian-Hui Wang

“…Necrotizing enterocolitis (NEC) is a lethal gastrointestinal tract disease that occurs in premature infants. Adenosine receptor A2B (A2BR) regulates the inflammation cytokine secretion and immune cell infiltration in the colonic pathophysiology conditions. …”
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