Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…This study aimed to explore the internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics and Olink proteomics. …”
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When herpes zoster is not herpes: A case of statin-induced myopathy complicated by drug allergies by Hira Khalid Kareem, Muhammad Fawad Ashraf, Muhammad Shehryar, Hafsa Fayyaz, Shreyas Patil

“…After discontinuing atorvastatin and clindamycin, her CK levels improved, and subsequent testing confirmed the presence of anti-HMG-CoA reductase antibodies, establishing a diagnosis of statin-induced autoimmune necrotizing myopathy. This case underscores the importance of detailed patient histories and the need to consider drug-induced hypersensitivity reactions in immunocompromised individuals. …”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…Another contributing factor appears to be sex, as sex-specific differences in the dopaminergic pathway are described in the neurological context as well as in autoimmune diseases. However, a deeper understanding of these differences in peripheral immune cells remains limited. …”
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What Do Gases in the Large Intestine Have to Do with Health? by Klaudia Pawełek, Patrycja Kinga Marta, Filip Maciej Huzarski, Gabriela Monika Ferfecka, Magdalena Rosa-Bończak, Agata Ossolińska, Weronika Kłosowicz, Oliver Carlton, Lucyna Stolarska, Natalia Morawiecka

“…Celiac disease, an autoimmune condition, causes damage to intestinal villi, impairing digestion and absorption. …”
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Aspirin does not confer protection against major ischemic vascular events in patients diagnosed with rheumatoid arthritis by Chao Gao, Qiqi Hou, Hongxia Cao, Cangtuo Li, Xu Peng, Quanle Han, Shouling Wu, Kangbo Li

“…Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammatory arthritis and extra-articular involvement. …”
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Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…Arthritis forms a vicious cycle, where upon overuse of a joint or an autoimmune reaction inflammation and pain occur. These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. …”
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Beyond the microbiome: unraveling gut dysbiosis and its impact on systemic lupus erythematosus by Yara Safwat Roshdy, Shwikar Mahmoud Ahmed, Mona Gamaleldeen Morsi, Ahmed Shaaban, Samar Farouk Fouad Mostafa

“…Background Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors, with gut microbiota (GM) changes emerging as a key environmental contributor.Methods A total of 42SLE patients and 30 age – and sex-matched healthy controls were enrolled. …”
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Rules for investigation of patients with asymptomatic elevation of serum aminotransferase activity by M. V. Mayevskaya, V. T. Ivashkin, Ye. N. German

“…Screening markers and specifying diagnostic tests are necessary to diagnose correct the majority of liver diseases – viral hepatites, alcoholic (ALD) and non-alcoholic fatty liver diseases (NAFLD), autoimmune hepatitis (AIH), Wilson diseases, primary hemochromatosis etc. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…Taken together with other reports on the efficacy of PEPITEM, this study paves the way for the development and translation of a novel class of anti-inflammatory agents which may have utility in a broad range of autoimmune and chronic inflammatory diseases.…”
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Therapeutic proteins immunogenicity: a peptide point of view by Feliciana Real-Fernandez, Fosca Errante, Andrea Di Santo, Anna Maria Papini, Paolo Rovero

“…Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune response to the drug. …”
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Alexithymia in multiple sclerosis: past, present and future by Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Moussa A. Chalah, Moussa A. Chalah, Moussa A. Chalah

“…In multiple sclerosis (MS), an autoimmune disease of the central nervous system, alexithymia seems to occur in up to 53% of patients. …”
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Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. Aim: The purpose of this study was to determine the difference in natural Treg levels in Entamoeba histolytica, Schistosoma mansoni, Giardia lamblia, Enterobius vermicularis, and Hymenolepis nana infected patients. …”
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Rett syndrome complicated by diabetes mellitus type 1 by Yasutaka Kuniyoshi, Satoru Takahashi

“…Anti-glutamic acid decarboxylase antibodies were positive, confirming autoimmune DM type 1. Fluid resuscitation and insulin therapy were initiated with good glycemic control on continuous subcutaneous insulin infusion. …”
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B-cell non-Hodgkin's lymphoma in the patient with chronic hepatitis C and mixed cryoglobulinemia by V. S. Adonyeva, Ye. A. Kolodyazhnaya, A. B. Bochkarev

“…Presented case shows development of B-cell non-Hodgkin's lymphoma in the patient with long-term infection of hepatitis C virus and autoimmune disorders, i.e. mixed cryoglobulinemia. Laboratory tests revealed moderate cytolytical activity: alanine transaminase (ALT) was 135 U/ml, aspartate aminotransferase (AST) —140 U/ml. …”
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Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia by Amal F. Alshammary, Ghada BinSaif, Imran Ali Khan

“…The Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene has been reported to be related to vitiligo and other autoimmune diseases. The purpose of this study was to explore the molecular involvement of rs231775 and rs3087243 SNPs in the CTLA4 gene in vitiligo patients. …”
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Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Etiopathogenesis of IBD represents the cascade of self-maintaining pathophysiological reactions: adaptive microcirculational, hypoxicmetabolic, autoimmune inflammatory and dysbiotic disorders emerging on a background of genetic features of the body under the effect of unfavorable environmental factors. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Introduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. …”
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Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype by Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge, Ji Yang

“…Abstract Background Dermatomyositis (DM) is an autoimmune disease with a high rate of disability and mortality especially in DM with concurrent interstitial lung disease (DM-ILD). …”
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The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study by Ahmad Mansour, Tomer Kerman, Nir Amitai, Eran Zunz, Soltan Khalaila, Itai Hazan, Erez Tsumi

“…Systemic diseases such as hypertension (OR 1.46), dyslipidemia (OR 1.45), and autoimmune rheumatic diseases (OR 1.43) were also associated with involutional ectropion. …”
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Incidence rate and associated patient characteristics of liver disease in Wales 2004–2022: a retrospective population-scale observational study by Ashley Akbari, Andrew Yeoman, Haroon Ahmed, Jingwei Gao, Aled Davies, Thomas Peter Ignatius Pembroke

“…A total of 79 992 individuals (72%) entered the cohort with the underlying aetiology of liver disease, including alcohol-related liver disease, non-alcoholic fatty liver disease (NAFLD), viral hepatitis, metabolic, haemochromatosis and autoimmune liver diseases. NAFLD has contributed to most of the change in incidence.Conclusions We observed increasing incidence rates of liver disease in Wales, with NAFLD showing a particularly sharp increase and frequently identified as an underlying condition. …”
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