Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel by Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang

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Idiopathic Peripheral Neuropathy Responsive to Sympathetic Nerve Blockade and Oral Clonidine by Jenna L. Walters, Daniel F. Lonergan, Robert D. Todd, Tracy P. Jackson

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Effects of Anesthetics on Barrier Tissue Function by Fujing Wang, Yanhui Li, Changlei Cui, Zhaoping Xue, Haichun Ma

“…Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. …”
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Skin Testing to Identify Safe Drugs for Patients with Rocuronium-Induced Anaphylaxis by Manzo Suzuki, Hajime Kawase, Azusa Ogita, Hiroyasu Bito

“…Among patients who develop anaphylaxis during anesthesia, anaphylaxis caused by a neuromuscular blocking agent has the highest incidence. …”
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Longitudinal impact of cross-clamp duration on postoperative sleep disturbance and quality of life in elderly cardiac surgery patients: a secondary analysis of the MINDDS trial by Grace E. Namirembe, Jamie Sparling, Alexis Novak, Ariel Mueller, Julia Bertsch, Kwame Wiredu, Jason Z. Qu, M. Brandon Westover, Timothy T. Houle, Oluwaseun Akeju

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Intraoperative haemodynamic optimisation using the Hypotension Prediction Index and its impact on tissular perfusion: a protocol for a randomised controlled trial by Javier Ripollés-Melchor, Ane Abad-motos, Juan Victor Lorente, Ignacio Jimenez, Alejandra Becerra, Wilbert Wesselink, Francesca Reguant, Irene Mojarro, Maria de los Angeles Fuentes, Elizabeth Agudelo, Francisco Herrero-Machancoses, Paula Callejo, Joan Bosch, Manuel Ignacio Monge

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Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education by Anna M. Lomanowska, Rabia Tahir, Christina Choo, Sabrina Zhu, Dora Y. Wang, P. Maxwell Slepian, Joel Katz, Hance Clarke

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A Multimodal Approach to Analgesia in Anorectal Surgery by T. N. Garmanova, D. R. Markaryan, E. A. Kazachenko, A. M. Lukianov, M. A. Kazachenko, M. A. Agapov

“…Stool softeners are recommended for reducing postoperative pain severity. Additional local anesthesia such as nerve blockade or infiltration anesthesia is recommended for all patients. …”
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Prevalence of Emergence Delirium and Associated Factors among Older Patients Who Underwent Elective Surgery: A Multicenter Observational Study by Gezahegn Tesfaye Mekonin, Megersa Kelbesa Olika, Mitiku Birhanu Wedajo, Ashanafi Tolasa Badada, Abebe Dukessa Dubiwak, Tajera Tageza Ilala, Mamo Nigatu Gebre

“…It occurs at any time in the perioperative period, during or immediately following emergence from general anesthesia. Unfortunately, it is highly associated with postoperative complications such as a decrease in functional capacity, prolonged hospital stay, an increase in health care costs, and morbidity and mortality. …”
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Reduced Effective Oxygen Delivery and Ventilation with a Surgical Facemask Placed under Compared to over an Oxygen Mask: A Comparative Study by Marvin G. Chang, Takashi Sakano, Benjamin S. Levin, David Convissar, Edward A. Bittner

“…Consensus guidelines for perioperative anesthesia management during the COVID-19 pandemic recommend that patients wear a facemask in addition to their oxygen mask or nasal cannulae following tracheal extubation, where this is practical. …”
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Comparative Evaluation of the Sniffing Position with Simple Head Extension for Laryngoscopic View and Intubation Difficulty in Adults Undergoing Elective Surgery by Smita Prakash, Amy G. Rapsang, Saurabh Mahajan, Shameek Bhattacharjee, Rajvir Singh, Anoop R. Gogia

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Subarachnoid Fluid Lactate and Paraplegia after Descending Aorta Aneurysmectomy: Two Compared Case Reports by Enrico Giustiniano, Silvia Eleonora Malossini, Francesco Pellegrino, Franco Cancellieri

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An Intensive Perioperative Regimen of Pregabalin and Celecoxib Reduces Pain and Improves Physical Function Scores Six Weeks after Total Hip Arthroplasty: A Prospective Randomized C... by Nicole ME Carmichael, Joel Katz, Hance Clarke, Deborah Kennedy, Hans J Kreder, Jeffrey Gollish, Colin JL McCartney

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Emergent Management of Intracardiac Thrombosis during Liver Transplantation by Caroline Protin, Dmitri Bezinover, Zakiyah Kadry, Thomas Verbeek

“…Intraoperative thromboembolism is a well-documented complication associated with orthotopic liver transplantation (OLT) but its identification and intraoperative treatment are still an emerging topic in anesthesia. Intracardiac thrombus during OLT is associated with a high mortality rate. …”
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Wernicke Encephalopathy Related to Hyperemesis Gravidarum: A Retrospective Study of 12 Cases by Kaouthar Abouelbaqua, Houssam Rebahi, Nisrine Louhab, Najib Kissani, Ahmed Rhassane El Adib

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The Perioperative NonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) Risk Stratification Tool by Laurence Weinberg, PhD, Dong Kyu Lee, PhD, Luke Fletcher, MD, Bobby Ou Yang, MD, Jadon Karp, MD, Anoop N Koshy, PhD, Ranjan Guha, FANZCA, Hugh Slifirski, MD, Michael R D’Silva, MD, Rinaldo Bellomo, PhD, Leonid Churilov, PhD

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Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner. by Caleb Larnerd, Maria Nolazco, Ashley Valdez, Vanessa Sanchez, Fred W Wolf

“…Ethanol memory-like states appear genetically and behaviorally paralleled to the canonical learning and memory traces anesthesia-sensitive, anesthesia-resistant, and long-term memory ASM, ARM, and LTM. …”
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Predictive Values of Preoperative Tests for Difficult Laryngoscopy and Intubation in Adult Patients at Tikur Anbessa Specialized Hospital by Tadese Tamire, Habtamu Demelash, Wosenyeleh Admasu

“…This is one of the most critical emergencies that may be faced in the practice of anesthesia. If the anesthetist can predict which patients are likely to prove difficult to intubate, he/she may reduce the risks of anesthesia considerably. …”
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Management of Severe COVID-19 in Pregnancy by Yassamine Abourida, Houssam Rebahi, Imane Oussayeh, Hajar Chichou, Bouchra Fakhir, Abderraouf Soummani, Hicham Jalal, Fatiha Bennaoui, Nadia El Idrissi Slitine, Fadl Mrabih Rabou Maoulainine, Ahmed Rhassane El Adib, Mohamed Abdenacer Samkaoui

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Waiting for Treatment for Chronic Pain – a Survey of Existing Benchmarks: Toward Establishing Evidence-Based Benchmarks for Medically Acceptable Waiting Times by Mary E Lynch, Fiona A Campbell, Alexander J Clark, Michael J Dunbar, David Goldstein, Philip Peng, Jennifer Stinson, Helen Tupper, the Canadian Pain Society Wait Times Task Force

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