A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons by Joon Pio Hong, Wei F. Chen, Dung H. Nguyen, Qingping Xie

“…The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells—including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau—are disposed of. Evidence is building that suggests disease progression in AD and other cognitive impairments could be explained by dysfunction in the brain's lymphatic system or obstruction of drainage. …”
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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex by Emily Petrus, Hey-Kyoung Lee

“…Alzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβ is produced in an activity-dependent manner and has physiological relevance to normal brain functions. …”
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Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model by Samuel de Mattos Alves, Paulo Noronha Lisboa-Filho, Carolina Letícia Zilli Vieira, Marina Piacenti-Silva

“…Research indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. …”
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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…KRASG12C, ATM, ALK2), and neurodegeneration (e.g. amyloid beta plaques, MAPK p38), while exploring the intricacies associated with developing novel radiotracers for CNS targets. …”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…In this study, an AD mouse model was established through lateral ventricular injection of amyloid-beta1–42 (Aβ1–42). Subsequently, adeno-associated virus was administered to overexpress SFPQ in the hippocampus of AD mice. …”
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Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation by Karla Salgado-Puga, Roberto A. Prado-Alcalá, Fernando Peña-Ortega

“…Alzheimer’s disease (AD) is associated with an early hippocampal dysfunction, which is likely induced by an increase in soluble amyloid beta peptide (Aβ). This hippocampal failure contributes to the initial memory deficits observed both in patients and in AD animal models and possibly to the deterioration in activities of daily living (ADL). …”
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Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review by Ubaid Ansari, Jimmy Wen, Burhaan Syed, Dawnica Nadora, Romteen Sedighi, Denise Nadora, Vincent Chen, Forshing Lui

“…In Alzheimer's and Parkinson's diseases, NP2 is linked to amyloid-beta aggregation and dopaminergic neuron degeneration, respectively. …”
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PROTEOMIC PROFILING OF BLOOD-BASED BIOMARKERS IN THE EARLY DETECTION OF ALZHEIMERS DISEASE by Syeda Uroosa Hashmi, Fahad Farooq Lasi

“…AD is linked directly to the amyloid-beta peptides. The monomeric forms of Aβ aggregate to form fibrils and a variety of oligomers which later become neurotoxic. …”
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Multivariate Analyses with Two-Step Dimension Reduction for an Association Study Between ¹¹C-Pittsburgh Compound B and Magnetic Resonance Imaging in Alzheimer’s Disease... by Atsushi Kawaguchi, Fumio Yamashita

“…The neuropathological diagnosis of Alzheimer’s disease (AD) relies on amyloid beta (Aβ) deposition in brain tissues. To study the relationship between Aβ deposition and brain structure, as determined using ¹¹C-Pittsburgh compound B (PiB) and magnetic resonance imaging (MRI), respectively, we developed a regression model with PiB and MRI data as the predictor and response variables, respectively, and proposed a regression method for studying the association between them based on a supervised sparse multivariate analysis with dimension reduction based on a composite paired basis function. …”
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High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface by Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li

“…Control experiments were performed with two closely related proteins, amyloid-beta and tau, to reveal the specificity; the results show that the aptamer only recognized alpha-synuclein. …”
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C/EBPβ in Alzheimer’s disease: An integrative regulator of pathological mechanisms by Xiaoting Luo, Junyi Liang, Xue Lei, Fengqi Sun, Minghai Gong, Bin Liu, Zhongguang Zhou

“…Alzheimer's disease (AD) stands as one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function, neuroinflammation, amyloid-beta (Aβ) plaques, and neurofibrillary tangles (NFTs). …”
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Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview by María Alejandra Cerquera-Jaramillo, Mauricio O. Nava-Mesa, Rodrigo E. González-Reyes, Carlos Tellez-Conti, Alejandra de-la-Torre

“…AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated tau protein. …”
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Amyloid β-Related Angiitis Causing Coma Responsive to Immunosuppression by Shennan A. Weiss, David Pisapia, Stephan A. Mayer, Joshua Z. Willey, Kiwon Lee

“…Introduction. Amyloid-beta-related angiitis (ABRA) is a form of CNS vasculitis in which perivascular beta-amyloid in the intracerebral vessels is thought to act as a trigger for inflammation mediated by CD68+ macrophages and CD3+ T lymphocytes. …”
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Lecanemab’s Path Forward: Navigating the Future of Alzheimer’s Treatment in Europe Amidst the EMA's Rejection by Alessandro Martorana, Chiara Giuseppina Bonomi, Martina Gaia Di Donna, Caterina Motta

“…Abstract Lecanemab (Leqembi©, Biogen), a humanized anti-amyloid-beta monoclonal antibody, has been approved for early-stage Alzheimer’s disease (AD) in several countries, including the US and Japan. …”
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Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study by Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima

“…Here, we investigated the therapeutic potential of secretome derived from dental pulp stem cells (DPSCs) to reduce cytotoxicity and apoptosis caused by amyloid beta (Aβ) peptide. We determined whether DPSCs can secrete the Aβ-degrading enzyme, neprilysin (NEP), and evaluated the effects of NEP expression in vitro by quantitating Aβ-degrading activity. …”
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A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats by Menuka M. Pallebage-Gamarallage, Virginie Lam, Ryusuke Takechi, Susan Galloway, John C. L. Mamo

“…Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect. …”
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The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases by Gustavo Sáenz-Ravello, Marcela Hernández, Mauricio Baeza, Patricia Hernández-Ríos

“…Additionally, salivary biomarkers like amyloid-beta and tau are promising in detecting neurodegenerative disorders. …”
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Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Furthermore, cilostazol therapy lowered hippocampal levels of amyloid beta 1–42 (Aβ1-42) and p-tau protein, both of which are critical pathological indicators of neurodegenerative disorders. …”
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Exploring peripheral fluid biomarkers for early detection of Alzheimer's disease in Down syndrome: A literature review by Charlotte Jacob, Marleen Tollenaere, Hanane Kachar, Marie-Claude Potier, Peter Paul De Deyn, Debby Van Dam

“…Apart from the classic amyloid beta and Tau biomarkers, we also discuss more out-of-the-box biomarkers such as neurofilament light chain, Dual-specificity tyrosine-regulated kinase 1A, and monoaminergic biomarkers. …”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. …”
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