Worldwide Research Trends on Diabetic Foot Ulcers (2004–2020): Suggestions for Researchers by Pin Deng, Hongshuo Shi, Xuyue Pan, Huan Liang, Shulong Wang, Junde Wu, Wei Zhang, Fasen Huang, Xiaojie Sun, Hanjie Zhu, Zhaojun Chen

“…Analysis showed that the global research hotspots of DFU focused on lower limb amputation, diabetic foot infection, and treatment and management of DFU. …”
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Temporary ectopic banking as a treatment option for mangled thumb: a case report by Meisam Jafari Kafiabadi, Adel Ebrahimpour, Seyyed Hamidreza Ayatizadeh, Reza Fereidooni, Amirhossein Kamalinia, Mehrdad Sadighi, Farsad Biglari, Seyed Arman Moein

“…Necrosis necessitated amputation through the first metacarpophalangeal joint. …”
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A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies by Yazhou Zhang, Steve A. McClain, Hsi-Ming Lee, Muna S. Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark Wolff, Francis Johnson, Lorne M. Golub

“…Impaired wound-healing in diabetics can lead to life-threatening complications, such as limb amputation, associated in part with excessive matrix metalloproteinase- (MMP-) mediated degradation of collagen and other matrix constituents. …”
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Effectiveness of an Innovative Pulsed Electromagnetic Fields Stimulation in Healing of Untreatable Skin Ulcers in the Frail Elderly: Two Case Reports by Fabio Guerriero, Emanuele Botarelli, Gianni Mele, Lorenzo Polo, Daniele Zoncu, Paolo Renati, Carmelo Sgarlata, Marco Rollone, Giovannoi Ricevuti, Niccolò Maurizi, Matthew Francis, Mariangela Rondanelli, Simone Perna, Davide Guido, Piero Mannu

“…Despite appropriate treatment, the ulcers showed little improvement and the risk of amputation was high. Both patients underwent daily EBS therapy and standard dressing. …”
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ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice by Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault

“…Abstract Background Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therapeutic interventions, the underlying mechanisms precipitating the progression of PAD to CLTI remain elusive. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…The results indicated that MBD could inhibit the inflammatory responses induced by CuSO₄, tail amputation and LPS in zebrafish. Furthermore, MBD notably inhibited the intestinal migration of immune cells, enhanced the integrity of the gut mucosal barrier and improved intestinal peristalsis function in a zebrafish IBD model induced by trinitro-benzene-sulfonic acid (TNBS). …”
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Outcomes of oncologic arthroplasty in children and adolescents with malignant limb tumors: a systematic review by Vyacheslav I. Zorin, Sergei V. Vissarionov, Alexandr Y. Makarov, Timofey S. Rybinskikh, Kristina N. Rodionova

“…Background. Amputation was historically the primary surgical intervention for children with limb bone sarcomas. …”
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Comparison and Analysis between the NAV6 Embolic Protection Filter and SpiderFX EPD Filter in Superficial Femoral Artery Lesions by Prakash Krishnan, Arthur Tarricone, Allen Gee, Serdar Farhan, Haroon Kamran, Annapoorna Kini, Samin Sharma

“…An MAE was defined as death, MI, TVR, thrombosis, dissection, distal embolization, perforation at the level of the filter, and unplanned amputation. A descriptive comparison of the MAE rates between Emboshield NAV6 and SpiderFX embolic protection devices was conducted. …”
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Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis by Kris Aubrey-Bassler, John-Michael Gamble, Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo A Marra, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen

“…Three studies reported on amputation, with one finding a significant increase risk. …”
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Faktor Risiko Terjadinya Ulkus Diabetikum pada Pasien Diabetes Mellitus yang Dirawat Jalan dan Inap di RSUP Dr. M. Djamil dan RSI Ibnu Sina Padang by Rizky Loviana Roza, Rudy Afriant, Zulkarnain Edward

“…Foot ulceration is preventable, and relatively simple interventions can reduce amputations by up to 80%. Amputation has a major impact on individual, not only in distorting body image, but also loss of productivity, increasing dependency, and expensive cost of treating foot ulcer. …”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…Furthermore, the hemostatic efficacy of AC-AgNPs is demonstrated in mouse models of tail amputation and liver injury, where AC-AgNPs significantly reduce the amount of blood loss and the bleeding time. …”
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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

“…For the simulation component, a long-term CEA was performed using a Markov state transition model on a simulated cohort of 10 000 patients with DFUs over a 20-year period, assessing transitions between health states, including minor and major amputations and death. The incremental cost-effectiveness ratio (ICER) was calculated for the DEFINITE Care program relative to routine care.Results The estimation of average treatment effects based on propensity scores showed that the DEFINITE Care group exhibited a 9% lower mortality, 5% higher lower extremity amputation (LEA)-free survival, yet a 5% higher minor LEA rate compared with the matched historical controls. …”
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Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae by Chenkai Ge, Zhijun Ye, Weitao Hu, Jingrong Tang, Huimin Li, Fasheng Liu, Xinjun Liao, Jianjun Chen, Shouhua Zhang, Zigang Cao

“…We exposed zebrafish larvae to 0, 5, 15, and 25 mg/L pyrazosulfuron-ethyl at 3 days after caudal fin amputation. It was found that exposure to pyrazosulfuron-ethyl significantly inhibited caudal fin regeneration and affected the behavior of zebrafish larvae. …”
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Foot screening and customized health education program for patients with diabetic peripheral neuropathy: A nurse-led, real-world observational study by Shuhong Liu, Hexiao Ding, Dandan Li, Fen Lu, Gumei Luo, Yujin He, Hui Li, Xiuhong Zeng, Kaixin Li, Dong-E Gong, Xiling Hu, Yanming Chen, Xubin Yang

“…Background: Research has shown that DPN affects 50 % of individuals with diabetes and, in severe cases, can lead to amputation or death. Interventions led by doctors for DPN have demonstrated limited effectiveness in delaying its onset and progression. …”
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Glycaemic Control Impact on Renal Endpoints in Diabetic Patients on Haemodialysis by Danielle Creme, Kieran McCafferty

“…Patients with diabetes had more amputations (24 versus 2). Conclusion. Large number of diabetic patients on haemdialysis have poor glycaemic control. …”
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Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds by Chiaki Kitamura, Tatsuji Nishihara, Masamichi Terashita, Yasuhiko Tabata, Ayako Washio

“…In this paper, we focus on the local regeneration of the dentin-pulp complex by application of exogenous growth factors and scaffolds to amputated dental pulp.…”
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ORTHOPAEDIC EMERGENCY CASES AT HASAN SADIKIN HOSPITAL BANDUNG CAUSED BY TRADITIONAL BONE SETTER PRACTICE by Hantonius Hantonius, Hermawan Nagar Rasyid, Gibran Tristan Alpharian

“…Twelve percent of amputations in our centre were related to bonesetter practice. …”
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Symptoms of Diabetes by Linda B. Bobroff

“…Diabetes that is uncontrolled can lead to blindness, kidney disease, heart disease, and amputations. Early diagnosis is critical! If you have any of the symptoms described in this fact sheet, see your health care provider right away! …”
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Symptoms of Diabetes by Linda B. Bobroff

“…Diabetes that is uncontrolled can lead to blindness, kidney disease, heart disease, and amputations. Early diagnosis is critical! If you have any of the symptoms described in this fact sheet, see your health care provider right away! …”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…Notably, the need for minor amputations was much higher in MDR cases (<i>p</i> < 0.001), as was the need for major amputations (<i>p</i> < 0.001). …”
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