The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs by Akira Yano, Kaori Ito, Yoshikatsu Miwa, Yoshito Kanazawa, Akiko Chiba, Yutaka Iigo, Yoshinori Kashimoto, Akira Kanda, Shinji Murata, Mitsuhiro Makino

“…The reduction of brain amyloid beta (Aβ) peptides by anti-Aβ antibodies is one of the possible therapies for Alzheimer’s disease. We previously reported that the Aβ peptide vaccine including the T-cell epitope of diphtheria-tetanus combined toxoid (DT) induced anti-Aβ antibodies, and the prior immunization with conventional DT vaccine enhanced the immunogenicity of the peptide. …”
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2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv... by Wei Dong, Yujia Peng, Guijie Chen, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan

“…Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer’s disease, have been closely associated with microbial alteration via the gut-brain axis. …”
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Oligodendrocyte precursor cells facilitate neuronal lysosome release by Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai

“…A similar reduction in OPC branching and neuronal lysosome accumulation is seen in an early-stage mouse model of Alzheimer’s disease. Our findings have implications for the prevention of age-related pathologies and the treatment of neurodegenerative diseases.…”
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Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN) by Tongya Yu, Yingying Lin, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Hui Quan, Yanxin Zhao, Xueyuan Liu

“…Microglia activation contributes to Alzheimer’s disease (AD) etiology, and microglia migration is a fundamental function during microglia activation. …”
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Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

“…Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer’s disease. Hyperpolarized [1-13C]pyruvate MRS has shown promise for neurological applications because it enables the real-time in vivo detection of glycolysis and oxidative phosphorylation flux. …”
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Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i> by Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray

“…Urban, family Apiaceae (CAW), improves cognitive function in mouse models of aging and Alzheimer’s disease and affects dendritic arborization, mitochondrial activity, and oxidative stress in mouse primary neurons. …”
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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…Qing Wang,1,&ast; Yishan Yin,2,&ast; Wei Liu,3,&ast; Lingyu Li,1 Zhen Wang,1 Yue Tian,1 Jing Fan1 1Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China; 2Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People’s Republic of China; 3Department of Emergency Critical Care Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jing Fan, Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China, Email sddzfanjing@163.comBackground: This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.Methods: We analyzed data from the 2011– 2012 and 2013– 2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). …”
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Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice by Oliver K. Fuller, Emma D. McLennan, Casey L. Egan, Nimna Perera, Lauren V. Terry, Jae Pyun, Mariana de Mendonca, Guilherme Defante Telles, Benoit Smeuninx, Emma L. Burrows, Ghizal Siddiqui, Darren J. Creek, John W. Scott, Michael A. Pearen, Pamali Fonseka, Joseph A. Nicolazzo, Suresh Mathivanan, Anthony J. Hannan, Grant A. Ramm, Martin Whitham, Mark A. Febbraio

“…Summary: Exercise improves cognitive function in Alzheimer’s disease (AD) via mechanism that are not fully clear. …”
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Search for signals of positive selection of circadian rhythm genes <i>PER1</i>, <i>PER2</i>, <i>PER3</i> in different human populations by A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva

“…In addition, many of the selection variants in the PER1, PER2, PER3 genes appear to regulate biological processes that are associated with major modern diseases, including obesity, cancer, metabolic syndrome, bipolar personality disorder, depression, rheumatoid arthritis, diabetes mellitus, lupus erythematosus, stroke and Alzheimer’s disease, making them extremely interesting targets for further research aimed at identifying the genetic causes of human disease.…”
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Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice by Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang

“…Abstract Background Apolipoprotein E4 (ApoE4) is associated with an increased risk of Alzheimer’s disease (AD), depression, and anxiety, which were reported to improve after the administration of metformin. …”
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Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation by Bong-Keun Jang, Soo Jung Shin, Hyun Ha Park, Vijay Kumar, Yong Ho Park, Jeom-Yong Kim, Hye-Yeon Kang, Sunyoung Park, Youngsun Kwon, Sang-Eun Shin, Minho Moon, Beom-Jin Lee

“…Background/Objectives: Aronia extract or its active compounds, especially anthocyanin, have shown potential for Alzheimer’s disease (AD)-related pathologies, including neuroinflammation, fibrillogenesis of amyloid beta (Aβ), and cognitive impairment. …”
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Proactive and Integrated Management and Empowerment in Parkinson’s Disease: Designing a New Model of Care by Emma Tenison, Agnes Smink, Sabi Redwood, Sirwan Darweesh, Hazel Cottle, Angelika van Halteren, Pieter van den Haak, Ruth Hamlin, Jan Ypinga, Bastiaan R. Bloem, Yoav Ben-Shlomo, Marten Munneke, Emily Henderson

“…Parkinson’s disease is the second most common neurodegenerative condition after Alzheimer’s disease. The number of patients will rise dramatically due to ageing of the population and possibly also due to environmental issues. …”
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Identification and Analysis of Components in Yizhi Granule and Cynomolgus Monkey Plasma after Oral Administration by UPLC/ESI-Q-TOF MS and Their Protective Effects on PC12 Cells by Erwei Hao, Jianfeng Qin, Wei Wei, Jianhua Miao, Yan Xie, Xianglong Pan, Hangxuan Wu, Jinling Xie, Xiaosu Fan, Zhengcai Du, Xiaotao Hou, Jiagang Deng

“…It can also provide some references for the research of Alzheimer’s disease.…”
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2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2 by Yae Jin Yoon, Yu-Jin Lee, Jiyeon Choi, Seung-Wook Chi, Sangku Lee, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han

“…2′-Hydroxycinnamaldehyde (HCA) is a component of the commonly used spice cinnamon, which has beneficial effects on cancer, allergies, bacterial/viral infections, and Alzheimer’s disease. Our previous study showed that HCA induced reactive oxygen species (ROS) and apoptosis in cancer cells, and pretreatment of cancer cells with antioxidants abolished HCA-mediated ROS production and apoptosis. …”
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Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…Our recent data further suggest that preE is associated with impaired autophagy, vascular dysfunction, and proteinopathy/tauopathy disorder, similar to neurodegenerative diseases such as Alzheimer’s disease (AD), including the presence of the cis stereo-isoform of phosphorylated tau (cis P-tau), amyloid-β, and transthyretin in the placenta and circulation. …”
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Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study by Zi-Han Yin, Qiong-Nan Bao, Ya-Qin Li, Yi-Wei Liu, Zi-Qi Wang, Fang Ye, Xia He, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Zi-Wen Chen, Ling Zhao, Fan-Rong Liang

“…The primary outcome was the change in the Alzheimer’s Disease Assessment Scale-Cognitive Scale (ADAS-Cog) score. …”
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Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…Thus, evidence has suggested that Al increases the risk of developing neurodegenerative diseases, particularly Alzheimer’s disease (AD). Purinergic signaling has been shown to play a role in several neurological conditions as it can modulate the functioning of several cell types, such as microglial cells, the main resident immune cells of the CNS. …”
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dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…Therapeutic strategies for Alzheimer’s disease (AD) often involve inhibiting acetylcholinesterase (AChE), underscoring the need for novel inhibitors with high selectivity and minimal side effects. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Concerning neurodegenerative disorders, smell impairments are often observed in Parkinson’s and Alzheimer’s diseases [7]. Functional imaging studies showed a reduced activity of the hippocampus and amygdala in response to odourous stimuli in patients with Parkinson’s disease compared with healthy controls. …”