Intertwined depressive and cognitive trajectories and the risk of dementia and death in older adults: a competing risk analysis by Jufen Liu, Ziyang Ren, Yushan Du, Lirong Nie

“…To date, their joint trajectories and associations with dementia and death remain underexplored.Aims To explore the interactions between depressive symptoms and cognitive function, their developmental trajectories and the associations with all-cause dementia, Alzheimer’s disease (AD) and all-cause death in older adults.Methods Data were from the Health and Retirement Study. …”
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Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition by Hannah C. Saternos, Kathleen V. Forero, Mahmood A. Meqdad, Raghad Buqaileh, Clare L. Sunderman, Gillian Gallagher, William S. Messer, Ashraf M. Mohieldin, Claudio A. Mucci, Sanjana Kumariya, Islam A. Osman, James P. Burkett, Wissam A. AbouAlaiwi

“…Decreased biosynthesis of NO contributes to cerebral amyloid angiopathy in Alzheimer’s disease (AD) patients through increased deposition of amyloid beta (Aβ). …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors. …”
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An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy. …”
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Rapid and Efficient Purification of Functional Collectin-12 and Its Opsonic Activity against Fungal Pathogens by Jie Zhang, Anna Li, Chang-qing Yang, Peter Garred, Ying Jie Ma

“…Furthermore, CL-12 has been shown to be associated with the pathogenesis of human diseases such as Alzheimer’s disease and multiple sclerosis lesion development. …”
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Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers by Pedro Lobos, Barbara Bruna, Alex Cordova, Pablo Barattini, Jose Luis Galáz, Tatiana Adasme, Cecilia Hidalgo, Pablo Muñoz, Andrea Paula-Lima

“…Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer’s disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce aberrant Ca2+ signals at sublethal concentrations and decrease the expression of type-2 ryanodine receptors (RyR2), which are crucial for hippocampal synaptic plasticity and memory. …”
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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain by Hao-Ming Xu, Hong-Li Huang, You-Lian Zhou, Hai-Lan Zhao, Jing Xu, Di-Wen Shou, Yan-Di Liu, Yong-Jian Zhou, Yu-Qiang Nie

“…We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).…”
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Feasibility of screening for cognitive impairment among older persons and referral by community health workers in Wakiso district, Uganda by Racheal Alinaitwe, Seggane Musisi, David Mukunya, Yvette Wibabara, Byamah B Mutamba, Noeline Nakasujja

“…The CHWs received a one-day training on causes, signs and symptoms, and management of cognitive impairment and screened older persons ≥ 60 years for cognitive impairment using the Alzheimer’s Disease scale 8 (AD8). Psychiatric clinical officers (PCOs) administered the AD8 to the older persons after assessment by the CHWs who then referred them for appropriate clinical care. …”
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Excess mortality and associated community risk factors related to hurricane Maria in Puerto Rico by Kristen N Cowan, Diego E Zavala, Erick Suarez, José A Lopez-Rodriguez, Omar Alvarez

“…Results: In the 6 months following Maria there were increases in mortality risk for cardiovascular disease, Alzheimer’s, diabetes, sepsis, chronic respiratory disease, hypertension and all-cause mortality. …”
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Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways by Julien Colas, Natacha Chessel, Allaeddine Ouared, Emmanuelle Gruz-Gibelli, Pascale Marin, François R. Herrmann, Armand Savioz

“…It suggests that the RA-dependent pathways belong to an anti-DSB Adaptative Gene Expression (DSB-AGE) system that can be targeted by prevention strategies to preserve memory in Alzheimer’s disease and aging.…”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Abstract Background Significant sex differences exist in the prevalence and incidence of Alzheimer’s disease (AD). Notably, testosterone has been reported to regulate cognitive functions in the brain, with low serum testosterone levels correlating with increased AD risk. …”
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice by Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zhu

“…Exposure to chronic psychiatric stress has been linked to Alzheimer’s disease-related tau hyperphosphorylation and abnormalities in glutamate neurotransmission. …”
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Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior by A. O. Bragin, O. V. Saik, I. V. Chadaeva, P. S. Demenkov, A. L. Markel, Yu. L. Orlov, E. I.  Rogaev, I. N. Lavrik, V. A. Ivanisenko

“…Alterations in neuronal apoptosis are observed in aging and neuropathologies accompanied by changes in psycho­emo­ tional state (epilepsy, Alzheimer’s disease, neurotrauma). The expression of key neuronal apoptosis genes (Casp3, Bax and Bcl-xl) in the brain of highly aggressive rats is significantly altered. …”
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Association between domain-specific physical activity and triglyceride‑glucose (TyG) index among US adults: Evidence from NHANES 2007–2018 by Kai Yao

“…Abstract Objectives The triglyceride-glucose (TyG) index is not only a reliable marker for insulin resistance, but also has broad applications in assessing the risk of various diseases, including cardiovascular disease, stroke, depression, and Alzheimer’s disease. The study aims to investigate the relationship between domain-specific moderate- or vigorous-intensity physical activity (MVPA) and TyG index among US adults. …”
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Neuroprotective Potential of <i>Origanum majorana</i> L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru, Lucian Hritcu

“…These findings underscore the potential of using <i>O. majorana</i> to improve memory impairment and reduce oxidative stress associated with cognitive disorders, including Alzheimer’s disease (AD).…”
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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington’s Disease (HD). …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…GV1001, a multifunctional peptide with anti-inflammatory, anti-cancer, antioxidant, and anti-Alzheimer’s properties, has demonstrated inhibition of EndMT. …”
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Antioxidant and cytotoxic activities of 2-oxo-1,2,3,4-tetrahydropyrimidines by Sarosh Iqbal, Shahida Perveen, M. Iqbal Choudhary, Musarrat Jabeen, Shumaila Kiran, Faiza Qayyum, Khalid Mohammed Khan

“…It contributes to the onset and progression of chronic inflammation, cancers, diabetes mellitus, atherosclerosis, Alzheimer’s disease, ocular disease, nephropathy, and premature aging. …”
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Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey by Pinto, Sara Martinho Almeida, Lacerda, Sara, Morfin, Jean-François, Aroso, Rafael Tiago,  Teixeira, Daniela Sofia de Sousa, Garda, Zoltán, Pereira, Maria Miguens,  Geraldes, Carlos Frederico Gusmão Campos, Tóth, Éva

“…For the specific targeting of amyloid peptides implicated in many pathologies such as Alzheimer’s disease and diabetes, they have designed benzothiazole-derivative metal chelates with detection potential in MRI, optical, and nuclear imaging modalities. …”
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Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer’s and Parkinson’s diseases. This review provides an overview of the basic molecular mechanisms involved in mitochondrial fusion and focuses on the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics. …”
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