Effectiveness of Tailored Multisensory Stimulation Intervention in People with Major Neurocognitive Disorder: A Quasiexperimental Pilot Study by Jèssica Garrido-Pedrosa, Elisabet Capdevila, Núria Berga-Quintana, Loreto González-Román, Maria Eulalia Guijosa-Mira, Irene Astilleros Castro, Jennifer Grau-Sánchez

“…Moreover, a substantial improvement in the participants’ quality of life, measured with the quality of life in Alzheimer’s disease (p=.03) and in neuropsychiatric symptoms (neuropsychiatric inventory-questionnaire, p=.04), was observed postintervention. …”
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Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications by Wang Meng, Wang Chao, Zhao Kaiwei, Ma Sijia, Sang Jiajia, Xu Shijie

“…These compounds have demonstrated significant anti-inflammatory, antioxidant, and neurogenic effects, making them promising candidates for the prevention and treatment of neurological conditions, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression. …”
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Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress by Göksel Şener, Gözde Karakadıoglu, Dilek Ozbeyli, Seren Ede, Refiye Yanardag, Ozlem Sacan, Asli Aykac

“…This study was designed to investigate whether Petroselinum crispum (PC) extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease (AD) rat model. The rats were divided into; control, scopolamine (1 mg/kg, i.p.), galantamine (1.5 mg/kg, i.p.) and PC extract (2 g/kg, p.o.)…”
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Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation by Marie-Theres Zeuner, Thomas Vallance, Sakthivel Vaiyapuri, Graeme S. Cottrell, Darius Widera

“…Aberrant activation of the transcription factor NF-κB, as well as uncontrolled inflammation, has been linked to autoimmune diseases, development and progression of cancer, and neurological disorders like Alzheimer’s disease. Reporter cell lines are a valuable state-of-the art tool for comparative analysis of in vitro drug screening. …”
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Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels by Zhikui Zhou, Baiyun Fan, Qiang Chen, Xuezhong Li, Xianjin Ke

“…Cognitive performance was assessed according to a composite Z-score of the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), and Digit Symbol Substitution Test (DSST). …”
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Psychobiotics, Novel Therapeutic Agents for the Psychiatric Disorders by Praveen Reddy P., K. Sandhya, Aparna Srikantam

“…Various neurological disorders such as Parkinson’s disease, Alzheimer’s disease, autism spectrum disorder in young children, stress, anxiety etc., are afflicting the people all over the world. …”
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

“…Neurodegenerative diseases such as Alzheimer’s disease (AD) pose substantial challenges to patients and health-care systems, particularly in countries with aging populations. …”
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Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…In this article, we highlight the application in the modeling of human neurodegenerative diseases (NDDs) such as FXS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and autistic spectrum disorders (ASD), and organoid-based drug screening. …”
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Humanin Rescues Cultured Rat Cortical Neurons from NMDA-Induced Toxicity Not by NMDA Receptor by Ai-Ling Cui, Jian-Zhong Li, Zhi-Bo Feng, Guo-Lin Ma, Liang Gong, Chun-Ling Li, Ce Zhang, Kefeng Li

“…Humanin is a 24-aa peptide cloned from the brain of patients with Alzheimer’s disease (AD). In the present study, excitatory toxicity was induced by N-methyl-D-aspartate (NMDA) in primarily cultured rat cortical neurons. …”
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Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease by Jihoon Jang, Soyeon Jeong, Sung Ik Lee, Wongi Seol, Hyemyung Seo, Ilhong Son, Dong Hwan Ho

“…Oxidative stress is the most critical risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD) and Huntington’s disease (HD). …”
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Exploring the microbiota-gut-brain axis: impact on brain structure and function by Lidya K. Yassin, Mohammed M. Nakhal, Alreem Alderei, Afra Almehairbi, Ayishal B. Mydeen, Amal Akour, Mohammad I. K. Hamad

“…We will therefore discuss how SCFAs can influence microglia, neuronal, and astrocyte function, as well as their role in brain disorders such as Alzheimer’s disease (AD), and Parkinson’s disease (PD). …”
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The protective role of GLP-1 in neuro-ophthalmology by Sohum Sheth, Aashay Patel, Marco Foreman, Mohammed Mumtaz, Akshay Reddy, Ramy Sharaf, Siddharth Sheth, Brandon Lucke-Wold

“…This article identifies the sources and targets of GLP-1 in the brain and review the mechanisms which mediate its neuroprotective effects, as well as implications for Alzheimer’s disease (AD) and Parkinson’s disease (PD). …”
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Microbial Characteristics and Functions in Coffee Fermentation: A Review by Xiaojing Shen, Qi Wang, Hongsheng Wang, Guoqing Fang, Ying Li, Jilai Zhang, Kunyi Liu

“…These compounds often relate to the prevention of cardiovascular disease, Alzheimer’s disease, and antibacterial, anti-diabetic, neuroprotection, and anti-cancer activities. …”
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Lysine Reacts with Cholesterol Hydroperoxide to Form Secosterol Aldehydes and Lysine-Secosterol Aldehyde Adducts by George Wafula Wanjala, Arnold Nola Onyango, David Rasugu Abuga, John Kamathi Muchuna, Calvin Onyango, Moses Makayoto

“…Two cholesterol secosterol aldehydes, namely, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxyaldehyde (secosterol B), are highly bioactive compounds which have been detected in human tissues and potentially contribute to the development of physiological dysfunctions such as atherosclerosis, Alzheimer’s disease, diabetes, and cancer. They were originally considered to be exclusive products of cholesterol ozonolysis and thus to be evidence for endogenous ozone formation. …”
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Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology by Rupal Dhariwal, Rupal Dhariwal, Mukul Jain, Mukul Jain, Yaser Rafiq Mir, Abhayveer Singh, Bhavik Jain, Pankaj Kumar, Mohd Tariq, Mohd Tariq, Devvret Verma, Khemraj Deshmukh, Virendra Kumar Yadav, Tabarak Malik, Tabarak Malik

“…By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. …”
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Splicing accuracy varies across human introns, tissues, age and disease by S. García-Ruiz, D. Zhang, E. K. Gustavsson, G. Rocamora-Perez, M. Grant-Peters, A. Fairbrother-Browne, R. H. Reynolds, J. W. Brenton, A. L. Gil-Martínez, Z. Chen, D. C. Rio, J. A. Botia, S. Guelfi, L. Collado-Torres, M. Ryten

“…We find support for the latter by observing a genome-wide increase in splicing inaccuracies in samples affected with Alzheimer’s disease as compared to neurologically normal individuals. …”
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A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice by Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Roy Haast, Dieter Lütjohann, Laus M. Broersen, Arend Heerschap, Amanda J. Kiliaan

“…APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. …”
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Genetic Risk Score Predicts Late-Life Cognitive Impairment by Mariegold E. Wollam, Andrea M. Weinstein, Judith A. Saxton, Lisa Morrow, Beth Snitz, Nicole R. Fowler, Barbara L. Suever Erickson, Kathryn A. Roecklein, Kirk I. Erickson

“…A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. …”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Furthermore, we present the role of PGC-1α in the pathogenesis of various neurological diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, and other PolyQ diseases. …”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD). β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation. …”
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