Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…Similarly, PDE5 dysregulation disrupts nitric oxide (NO) signaling and protein kinase G (PKG) pathways, which are involved in cerebrovascular homeostasis, recovery after ischemic events, and neurodegenerative processes in Alzheimer’s, Parkinson’s, and Huntington’s diseases. …”
Get full text

Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons by Se-In Lee, Heejin Lim, Na Yeon Kim, Jichang Yu, Joonho Cho, Hyein Lee, Dae Won Moon, Jinsoo Seo

“…Amyloid-β (Aβ), a hallmark of Alzheimer’s disease (AD), is generated from the sequential cleavage of amyloid precursor proteins (APPs) by β- and γ-secretases, primarily within endosomes after APP endocytosis by canonical clathrin-mediated endocytosis in neurons. …”
Get full text

Hydrolase-Treated Royal Jelly Attenuates H2O2- and Glutamate-Induced SH-SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of Vascular Dementia by Nualpun Sirinupong, Worrapanitch Chansuwan, Pratchaya Kaewkaen

“…Vascular dementia (VaD) is the second most common type of dementia following Alzheimer’s disease, but the therapeutic efficacy is still not effective. …”
Get full text

Association of Social Engagement with Brain Volumes Assessed by Structural MRI by Bryan D. James, Thomas A. Glass, Brian Caffo, Jennifer F. Bobb, Christos Davatzikos, David Yousem, Brian S. Schwartz

Get full text

The Role of Pharmaceutical Innovation in Clinical Practice Guidelines for Chronic Diseases by Meaghan Roach, Natalie Land, Jennifer Hernandez, Reina Rau, Jacquelyn W. Chou, Stacey S. Hickson, Danielle F. Rollmann, J. Ross Maclean

“…Clinical practice guidelines published from 2000 to 2021 were identified for five chronic diseases: ischemic heart disease (IHD), non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), and type 2 diabetes (T2D). …”
Get full text

Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice by Nhung Ha Thuy Le, Seon Ah Park, Yu Mi Kim, Dong Kuk Ahn, Won Jung, Seong Kyu Han

“…Glutamate excitotoxicity is considered as the etiology of stroke and neurodegenerative diseases, namely, Parkinson’s disease (PD), Alzheimer’s disease (AD), and others. Meanwhile, substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc), a pivotal site in regulating orofacial nociceptive transmission via Aδ and C primary afferent fibers, majorly utilize glutamate as the principal excitatory neurotransmitter. …”
Get full text

Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> by Julia Tortajada-Pérez, Andrea del Valle Carranza, Cristina Trujillo-del Río, Mar Collado-Pérez, José María Millán, Gema García-García, Rafael Pascual Vázquez-Manrique

“…This disruption contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, or Huntington’s disease. The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.…”
Get full text

Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…Deviations in brain metabolism are the result of longterm pathological processes, which finally are manifested as symptoms of Parkinson’s or Alzheimer’s diseases or multiple sclerosis and other neuropathologies, as for example diabetic neuropathy. …”
Get full text

Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain by Zhong-Sen Qu, Liang Li, Xiao-Jiang Sun, Yu-Wu Zhao, Jin Zhang, Zhi Geng, Jian-Liang Fu, Qing-Guo Ren

“…Diabetes mellitus (DM) and Alzheimer’s disease (AD) are characterized by amyloid deposits. …”
Get full text

Association between osteoarthritis and cognitive function: results from the NHANES 2011–2014 and Mendelian randomization study by Kun Zhao, Liuyan Nie, Jingting Zhao, Yankai Dong, Kaixiu Jin, Song Wang, Xiangming Ye

“…Genetically predicted specific-site OA was not significantly associated with the risk of dementia (OR = 1.12; 95% CI: 0.96–1.32; p = 0.16), Alzheimer’s disease (OR = 0.95, 95% CI: 0.68–1.31, p = 0.74), vascular dementia (OR = 1.32, 95% CI: 0.82–2.13, p = 0.25) with accepted heterogeneity and no evidence of directional pleiotropy. …”
Get full text

Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients by Yan Lv, Huijuan Chen, Zhiyan Sui, Yingliu Huang, Shixiong Huang, Feng Chen, Guoqiang Wen

“…Vascular dementia, secondary to Alzheimer’s dementia, ranks as one of the most frequent dementia types. …”
Get full text

Cognitive Planning Improved After Cycling Exercise in Older Adults with Down Syndrome by Shannon D. R. Ringenbach, Nathaniel E. Arnold, Forouzan Rafiei Rezvani, Chih-Chia Chen

“…Background/Objectives: Cognitive functions are a crucial part of daily living, especially for adults with Down syndrome (DS) who have a high likelihood of developing Alzheimer’s disease in adulthood. In addition, adults with DS move slower and are not meeting the standard aerobic activity guidelines each week. …”
Get full text

Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles by Tenesha Connor, Hemal Weerasinghe, Justin Lathia, Clemens Burda, Murat Yildirim

“…Their stability enables long-term, targeted drug delivery and photodynamic therapy, presenting potential therapeutic applications in treating brain tumors, Alzheimer’s disease, and traumatic brain injury. This review highlights the impact of QDs on MPM, their effectiveness in overcoming light attenuation in deep tissue, and their expanding role in diagnosing and treating neurological disorders, positioning them as transformative agents for both brain imaging and intervention.…”
Get full text

Genetic proxies for clinical traits are associated with increased risk of severe COVID-19 by N. J. M. Chaddock, S. S. R. Crossfield, M. Pujades-Rodriguez, M. M. Iles, A. W. Morgan

“…In univariate analyses, 17 PRS were associated with increased risk of severe COVID-19 and, of these, four remained associated with COVID-19 outcomes following adjustment for sociodemographic/clinical variables: hypertension PRS (OR = 1.1, 95%CI 1.03–1.18), atrial fibrillation PRS (OR = 1.12, 95%CI 1.03–1.22), peripheral vascular disease PRS (OR = 0.9, 95%CI 0.82–0.99), and Alzheimer’s disease PRS (OR = 1.14, 95%CI 1.05–1.25). …”
Get full text

Understanding the Impact of Urinary Incontinence in Persons with Dementia: Development of an Interdisciplinary Service Model by Patrick Juliebø-Jones, Elizabeth Coulthard, Elizabeth Mallam, Hilary Archer, Marcus J. Drake

“…Majority of persons had a diagnosis of Alzheimer’s disease (n = 43, 57%). Average score for how much urine leakage interferes with everyday life was 7.7/10 (range 2–10). 58.7% (n = 44) revealed some degree of sleep disturbance due to UI. 83% (n = 62) stated daily activities were limited due to UI. …”
Get full text

The Impact of the COVID-19 Pandemic on the Mental Health of Older Primary Care Patients and Their Family Members by Tara Seibert, Matthew W. Schroeder, Anthony J. Perkins, Seho Park, Eleanor Batista-Malat, Katharine J. Head, Tamilyn Bakas, Malaz Boustani, Nicole R. Fowler

“…Participants were dyads enrolled in the Caregiver Outcomes of Alzheimer’s Disease Screening (COADS) trial, which included 1,809 dyads of older primary care patients and one of their family members. …”
Get full text

Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 by Wai Wa Ray Chan, Jessica Chow, Dennis Dik-Long Chau, Yuqi Zhai, Kwok-Fai Lau

“…The brain-enriched adaptor protein FE65 has been shown to interact with Alzheimer’s disease amyloid precursor protein (APP) to alter the processing of APP. …”
Get full text

TDP-43 as a potential retinal biomarker for neurodegenerative diseases by Margit Glashutter, Margit Glashutter, Printha Wijesinghe, Joanne A. Matsubara, Joanne A. Matsubara

“…These include amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), and others. …”
Get full text

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Abstract Aggregation of microtubule-associated tau protein is a distinct hallmark of several neurodegenerative disorders such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP). …”
Get full text

Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD by Bernard Croisile, Samar Dimachki, Franck Tarpin-Bernard, Hanna Chainay

“…Introduction Recent studies on cognitive training in patients with Alzheimer’s disease (AD) showed positive long-term effects on cognition and daily living, suggesting remote computer-based programmes to increase training sessions while reducing patient’s travelling. …”
Get full text