Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles by Qiong Pan, Ya-Qian Li, Ke Guo, Min Xue, Yu Gan, Kejian Wang, Da-Bao Xu, Qiu-Yun Tu

“…As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. …”
Get full text

DFT Calculations and Molecular Docking Studies on a Chromene Derivative by Najet Aouled Dlala, Younes Bouazizi, Houcine Ghalla, Naceur Hamdi

“…Finally, Chrom-D has been evaluated as a multifunctional agent against Alzheimer’s disease (AD).…”
Get full text

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment by Shijin Xia, Xinyan Zhang, Songbai Zheng, Ramin Khanabdali, Bill Kalionis, Junzhen Wu, Wenbin Wan, Xiantao Tai

“…Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer’s disease, atherosclerosis, heart disease, type II diabetes, and cancer. …”
Get full text

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…In this review, the research history and milestone events of studying metal ions, including iron, manganese, copper, and zinc in neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), will be introduced. …”
Get full text

Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy? by Jisu Elsa Jacob, Ajith Cherian, K. Gopakumar, Thomas Iype, Doris George Yohannan, K. P. Divya

“…Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer’s disease, sleep disorders, and depression. …”
Get full text

Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function by Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E. Müller

“…The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer’s disease. Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. …”
Get full text

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche by Alejandro Luarte, Luis Federico Bátiz, Ursula Wyneken, Carlos Lafourcade

“…Novel approaches using various types of stem cells have been proposed to treat common neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease, or stroke. …”
Get full text

Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins by Sajad Chamani, Vanessa Bianconi, Aida Tasbandi, Matteo Pirro, George E. Barreto, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In recent years, compelling evidence has shown that impairment of resolution of inflammation is a crucial pathogenic hallmark in different neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. This review summarizes current knowledge on the role of resolvins in resolution of inflammation and highlights available evidence showing the neuroprotective potential of EPA- and DHA-derived resolvins (E-series and D-series resolvins, respectively) in neurodegenerative diseases.…”
Get full text

Complex Brain Network Analysis and Its Applications to Brain Disorders: A Survey by Jin Liu, Min Li, Yi Pan, Wei Lan, Ruiqing Zheng, Fang-Xiang Wu, Jianxin Wang

“…It is well known that most brain disorders are complex diseases, such as Alzheimer’s disease (AD) and schizophrenia (SCZ). In general, brain regions and their interactions can be modeled as complex brain network, which describe highly efficient information transmission in a brain. …”
Get full text

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives by Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valeriani

“…The management of neurodegenerative diseases such as Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington’s disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. …”
Get full text

The role of structural viscoelasticity in deformable porous media with incompressibleconstituents: Applications in biomechanics by Maurizio Verri, Giovanna Guidoboni, Lorena Bociu, Riccardo Sacco

“…Interestingly, the loss of viscoelastic tissue properties has been associated with various disease conditions, such as atherosclerosis, Alzheimer’s disease and glaucoma. Thus, the findings of this work may be relevant to many applications in biology and medicine.…”
Get full text

Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population by Johannes Lange, Kristin Aaser Lunde, Camilla Sletten, Simon Geir Møller, Ole-Bjørn Tysnes, Guido Alves, Jan Petter Larsen, Jodi Maple-Grødem

“…Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. …”
Get full text

A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…Analysis of the scientific literature allowed us to identify changes in the expression of 40 microRNAs derived from transposons in Alzheimer’s disease. For 24 of these microRNAs, the mechanisms of regulation of genes involved in the functioning of the brain have been described. …”
Get full text

Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders by Mi Eun Kim, Jun Sik Lee

“…While acute neuroinflammation plays a protective role by facilitating pathogen clearance and tissue repair, chronic and dysregulated inflammation contributes significantly to the progression of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Multiple Sclerosis. …”
Get full text

A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024 by Xia Li, Wei Su, Lili Cai

“…The University of Toronto and the Journal of Alzheimer’s Disease were identified as key contributors to this field. …”
Get full text

A Corticobasal Syndrome Variant of Familial Creutzfeldt-Jakob Disease with Stroke-Like Onset by Ján Necpál, Martin Stelzer, Silvia Koščová, Michal Patarák

“…Various neurodegenerative disorders are manifested with CBS as a clinical phenotype, including corticobasal degeneration (CBD), progressive supranuclear palsy, Alzheimer’s disease, and CJD. In our patient, mutation E200K and M129M polymorphism of the PRNP gene and typical immunohistochemical findings pointed to a diagnosis of CJD. …”
Get full text

Peripheral proteinopathy in neurodegenerative diseases by Bin Xu, Xia Lei, Ying Yang, Jiayi Yu, Jun Chen, Zhi Xu, Keqiang Ye, Jing Zhang

“…Abstract Proteinopathies in neurology typically refer to pathological changes in proteins associated with neurological diseases, such as the aggregation of amyloid β and Tau in Alzheimer’s disease, α-synuclein in Parkinson’s disease and multiple system atrophy, and TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal dementia. …”
Get full text

Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations by Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierks

“…In Alzheimer’s disease (AD), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of AD. …”
Get full text

Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model by Maitham Ahmed Al-Sammak, Douglas G. Rogers, Kyle D. Hoagland

“…Long-term exposure to L-BMAA is believed to lead to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases and amyotrophic lateral sclerosis (Lou Gehrig’s disease). …”
Get full text

Acquired Localized Hypertrichosis Induced by Rivastigmine by Adrian Imbernón-Moya, Sebastian Podlipnik, Fernando Burgos, Elena Vargas-Laguna, Antonio Aguilar-Martínez, Eva Fernández-Cogolludo, Miguel Angel Gallego-Valdes

“…We report on a Caucasian 80-year-old male with personal history of Alzheimer’s disease. The patient started therapy with oral rivastigmine one month prior to clinical presentation of localized hypertrichosis on both forearms. …”
Get full text