Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases by Marjana Brkic, Sriram Balusu, Claude Libert, Roosmarijn E. Vandenbroucke

“…Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS). …”
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Synergistic effects of mutation and glycosylation on disease progression by Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh

“…Inherited missense mutations in glycosylated proteins such as NOTCH3, Low-density lipoprotein receptor (LDLR), and Amyloid precursor protein (APP) could affect their glycosylation states, leading to cerebral small vessel disease, hypercholesterolemia, and Alzheimer’s disease, respectively. Additionally, physiological states and aging-related conditions can affect the expression levels of glycosyltransferases. …”
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Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease by Géraldine Gelders, Veerle Baekelandt, Anke Van der Perren

“…Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…Higher FGCRS was associated with increased all-cause dementia risk after adjusting for demographic, major lifestyle, clinical factors and the polygenic risk score (PRS) of Alzheimer’s disease. Comparing the high versus low tertile of FGCRS, the odds ratios (ORs) and 95% confidence intervals (CIs) were 1.26 (1.12 to 1.41) for all-cause dementia, 1.67 (1.33 to 2.09) for Alzheimer’s disease and 1.53 (1.07 to 2.16) for vascular dementia (all ptrend<0.05). …”
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Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…Dysfunctional zinc signaling is associated with a number of chronic disease states including cancer, cardiovascular disease, Alzheimer’s disease, and diabetes. Cellular homeostasis requires mechanisms that tightly control the uptake, storage, and distribution of zinc. …”
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Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia by Caitlin A. Finney, David A. Brown, Artur Shvetcov

“…Data was sourced from the Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). …”
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Laser Therapy and Dementia: A Database Analysis and Future Aspects on LED-Based Systems by Daniela Litscher, Gerhard Litscher

“…Mainly because of the movement in the age pyramid, one can assume that the incidence of Alzheimer’s disease or dementia in general will increase in the coming decades. …”
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MicroRNAs in Neurotoxicity by Prameet Kaur, Arunmozhiarasi Armugam, Kandiah Jeyaseelan

“…Neurotoxicity-mediated pathophysiological conditions could then manifest as diseases or disabilities like Parkinson’s and Alzheimer’s which have debilitating implications. Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. …”
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D-Amino Acids in the Nervous and Endocrine Systems by Yoshimitsu Kiriyama, Hiromi Nochi

“…Aberrant receptor activity is related to diseases of the central nervous system (CNS), such as Alzheimer’s disease, amyotrophic lateral sclerosis, and schizophrenia. …”
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Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson’s Disease by Guanyu Zhang, Jinghong Ma, Piu Chan, Zheng Ye

“…Semantic disfluency is a common problem in Parkinson’s disease (PD) and Alzheimer’s disease (AD). We demonstrated a graph theoretical analysis of semantic fluency in patients with PD (N=86), patients with AD (N=40), and healthy controls (HC, N=88). …”
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From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases by Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrier

“…The review will end with a chapter on the prion-like propagation of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease and tauopathies.…”
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Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation by Pijush Chakraborty, Markus Zweckstetter

“…Abstract The pathological deposition of tau and amyloid-beta into insoluble amyloid fibrils are pathological hallmarks of Alzheimer’s disease. Molecular chaperones are important cellular factors contributing to the regulation of tau misfolding and aggregation. …”
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Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System by Woo Fong Yen, Mahiran Basri, Mansor Ahmad, Maznah Ismail

“…Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. …”
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Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode by Shindy Ayu Netania Priyanto, Elly Septia Yulianti, Ahmad Zakiyuddin, Siti Fauziyah Rahman

“…However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defined as an analytical tool that combines certain biological recognition components with a physical transducer. …”
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Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry by Xiaojing Long, Chunxiang Jiang, Lijuan Zhang

“…Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer’s disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. …”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo by G. D. Rabinovici, W. J. Jagust

“…PIB binds specifically to fibrillar beta-amyloid (Aβ) deposits, and is a sensitive marker for Aβ pathology in cognitively normal older individuals and patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). PIB-PET provides us with a powerful tool to examine in vivo the relationship between amyloid deposition, clinical symptoms, and structural and functional brain changes in the continuum between normal aging and AD. …”
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Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging by Zhenwei Gong, Radhika H. Muzumdar

“…The higher incidence of diabetes is especially alarming considering that diabetes in itself increases the risk for multiple other age-related diseases such as cancer, stroke, cardiovascular diseases, Parkinson’s disease, and Alzheimer’s disease (AD). In this review, we summarize the current evidence on how aging affects pancreatic β cell function, β cell mass, insulin secretion and insulin sensitivity. …”
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The WAVE complex in developmental and adulthood brain disorders by Hyung-Goo Kim, Clara Berdasco, Angus C. Nairn, Yong Kim

“…In addition, alterations in the WAVE complex are implicated in the pathophysiology of Alzheimer’s disease and Parkinson’s disease, as well as in behavioral adaptations to psychostimulants or maladaptive feeding.…”
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Usability Pitfalls of Diabetes mHealth Apps for the Elderly by Maša Isaković, Urban Sedlar, Mojca Volk, Janez Bešter

“…Diabetes mellitus has high prevalence in the ageing population and is often accompanied by other comorbidities, such as Alzheimer’s disease, and general disabilities, such as poor eyesight. …”
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Relationship between Zinc (Zn2+) and Glutamate Receptors in the Processes Underlying Neurodegeneration by Bartłomiej Pochwat, Gabriel Nowak, Bernadeta Szewczyk

“…Under clinical conditions, hyperactivity of the glutamate system is associated with ischemia, epilepsy, and neurodegenerative diseases such as Alzheimer’s, Huntington’s, and many others. The achievement of glutamate activity in the physiological range requires efficient control by endogenous regulatory factors. …”
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