Delaying Onset of Dementia: Are Two Languages Enough? by Morris Freedman, Suvarna Alladi, Howard Chertkow, Ellen Bialystok, Fergus I. M. Craik, Natalie A. Phillips, Vasanta Duggirala, Surampudi Bapi Raju, Thomas H. Bak

“…Although there were differences in results across studies, a common theme was the significant effect of language use history as one of the factors in determining the onset of Alzheimer’s disease. Moreover, the Hyderabad study extended the findings to frontotemporal dementia and vascular dementia.…”
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Trends for Clinical Trials on Medicinal Products for Neurological Disorders in Lithuania and Europe by Emilijus Žilinskas, Arūnas Vaitkevičius

“…The majority of the trials (363 (17.20%)) were clinical trials for Alzheimer’s disease and other dementias. During the period of 2012–2021, there was a significant decrease in the annual registration rate of clinical trials for Alzheimer’s disease and other dementias (R² = 0.751, p = 0.001) and an increase of clinical trials for myoneural junction and muscle diseases and motor neuron disease (R² = 0.582, p = 0.010 and R² = 0.635, p = 0.006, accordingly). …”
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Frontotemporal dementia: peculiarities of clinical variants by B. Klimbytė, A. Vaitkus

“…Conventional neuropsychological tests used in the diagnosis of Alzheimer’s disease are not sensitive enough to assess cognitive impairment in the frontal lobes. …”
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Medicinal Effect of Nutraceutical Fruits for the Cognition and Brain Health by Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani

“…The recent era is witnessing evaluation of medicinal and nutritional value of fruits and fruit juices for the management and prevention of brain diseases like headache stress, anxiety, hypertension, and Alzheimer’s and Parkinson’s diseases by the scientists and researchers worldwide. …”
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In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders by Harry Pantazopoulos, Sabina Berretta

“…Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. …”
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An Approach to Diagnostic Criteria for the Definition of Slight Cognitive Impairment by Julio Armas Castro, Mayra Rosa Carrasco García, Sussette Angell Valdés, Yanet López Mena

“…For years the term slight cognitive impairment has been used in literature as a transitional stage between normal aging and a slight Alzheimer’s disease and in conversion studies it has been associated to quantitative and qualitative alterations that support that support the hypothesis that slight cognitive impairment constitutes an early stage of dementia in most of the patients. …”
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Effect of Combined Antihypertensive and Lipid-Lowering Therapies on Cognitive Function: A New Treatment Strategy? by Ze-Min Kuang

“…Actively controlling potential risk factors from middle age may be important for Alzheimer’s disease (AD) prevention.…”
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Modal Logic, Probability and Machine Learning Systems for Metadata Extraction by Simone Cuconato

“…The result is a well-motivated system of probabilistic modal logic, that defines a probability distribution over possible worlds of the truth value of metadata extracted from precision medicine approach to Alzheimer’s disease articles through machine learning systems.…”
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COMBINATION OF MULTILAYER Ag-Al FOR OPTICAL BIOSENSOR BASED ON SURFACE PLASMON RESONANCE by Tan Tai Nguyen

“…This leads us to believe that the proposed SPR sensor can be used to detect biological targets during the clinical diagnosis of diseases, e.g., heart disease, Alzheimer’s disease, cardiovascular disease, and stroke. …”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer’s disease leads to an impairment of cognitive processes. …”
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Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS by Sebastián Beltrán-Castillo, Jaime Eugenín, Rommy von Bernhardi

“…D-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like Alzheimer’s disease.…”
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Statistical identification of cell type-specific spatially variable genes in spatial transcriptomics by Lulu Shang, Peijun Wu, Xiang Zhou

“…Applied to five real datasets, Celina uncovers ct-SVGs associated with tumor progression and patient survival in lung cancer, identifies metagenes with unique spatial patterns linked to cell proliferation and immune response in kidney cancer, and detects genes preferentially expressed near amyloid-β plaques in an Alzheimer’s model.…”
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A Review of the Healthcare and Social Care Needs of the Older Prisoner Population in England and Wales by Paul Gavin, Cody Normitta Porter, Finley MacDonald

“…This paper provides an overview of the main challenges facing older prisoners in the context of their health and social care needs, including the development of mental health problems such as Alzheimer’s and dementia, as well as challenges related to mobility and engaging in structured activities in prison. …”
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The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation by Ekta Bajwa, Caitlin B. Pointer, Andis Klegeris

“…In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation.…”
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FAACOSE: A Fast Adaptive Ant Colony Optimization Algorithm for Detecting SNP Epistasis by Lin Yuan, Chang-An Yuan, De-Shuang Huang

“…We compared our method with other existing methods using synthetic datasets and applied the proposed method to Late-Onset Alzheimer’s Disease dataset. Our experimental results show that the proposed method outperforms other methods in epistasis detection, and the result of real dataset contributes to the research of mechanism underlying the disease.…”
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Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. …”
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White Matter Injury in Central Nervous System Disorders by Zheng L, Wang X, Li P, Hao Y, Zhang H, Chen H, Zheng Z

“…In this article, we will briefly describe the structure and function of white matter, summarize the pathological changes of WMI, and focus on the molecular mechanisms and therapeutic research advances in WMI after ischemic stroke, cerebral hemorrhage, Alzheimer’s disease, and multiple sclerosis diseases.Keywords: white matter injury, central nervous system, oligodendrocytes, myelin…”
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Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder? by Jay P. Patel, Benicio N. Frey

“…There has been growing evidence that BBB disruption is associated with brain inflammatory conditions such as Alzheimer’s disease and multiple sclerosis. Considering the increasing role of inflammation and oxidative stress in the pathophysiology of bipolar disorder (BD), here we propose a novel model wherein transient or persistent disruption of BBB integrity is associated with decreased CNS protection and increased permeability of proinflammatory (e.g., cytokines, reactive oxygen species) substances from the peripheral blood into the brain. …”
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Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans by Maxwell A. Virus, Evie G. Ehrhorn, LeeAnna M. Lui, Paul H. Davis

“…Consequently, several studies have examined the link between T. gondii infection and diseases such as schizophrenia, epilepsy, depression, bipolar disorder, dysphoria, Alzheimer’s disease, Parkinson’s disease, and obsessive-compulsive disorder (OCD). …”
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Exploring environmental factors contributing to Parkinson’s disease in AfrAbian populations by Wael Mohamed

“…Neurological diseases, including neurodegenerative syndromes like Alzheimer’s disease, Parkinson’s disease, and motor neuron illnesses, have been increasingly seen and recorded in the scientific literature. …”
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