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161
Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases
Published 2024-01-01“…In this review, family members, characterizations, structure, functions and related signaling pathways, and therapeutic values of PLD was summarized, then five representative diseases including Alzheimer disease (AD), Parkinson’s disease (PD), etc. were selected as examples to tell the involvement of PLD in these neurological diseases. …”
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162
Neuropsychiatric symptoms in Alzheimer’s disease
Published 2024-02-01“…Neuropsychiatric symptoms worsen everyday activities, quality of life, and ability to socialise of people with Alzheimer's disease, making the diagnosis and treatment of these symptoms increasingly important. …”
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163
Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes
Published 2011-01-01“…Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly. …”
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164
Clinical Interaction between Brain and Kidney in Small Vessel Disease
Published 2011-01-01“…Recently, changes in the vascular system of the brain have been shown to contribute to the onset and progression of cognitive impairment, not only vascular dementia but also Alzheimer's disease. Patients with CKD are also reported to have higher risk of impaired cognitive function in the future compared with non-CKD subjects. …”
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165
Cross-Talk between Apolipoprotein E and Cytokines
Published 2011-01-01“…Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. …”
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166
Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein.
Published 2021-01-01“…P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ) protein have produced contradictory results. …”
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167
Storage and Processing Working Memory Functions in Alzheimer-Type Dementia
Published 1999-01-01“…In the present study, we have adapted a procedure used to investigate age-related memory modifications, involving both verbal and visuo-spatial material in tasks tapping passive and active processes, to investigate the deterioration associated with Alzheimer's disease. A group of Alzheimer patients in the early stages of the disease were matched to a control group of healthy elderly. …”
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168
Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review
Published 2025-01-01“…The primary neuropathological diagnosis was Alzheimer's Disease Neuropathologic Change (ADNC), present predominantly in intermediate to severe forms. …”
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169
EVALUATION OF THE THERAPEUTIC EFFECTS OF SALVIA ROSMARINUS ESSENTIAL OIL ON NERVOUS SYSTEM DISORDERS
Published 2025-02-01“…This review explores the therapeutic potential of rosemary in alleviating nervous system disorders such as Alzheimer's disease (AD), major depressive disorder (MDD), epilepsy, Parkinson's disease (PD), addiction, and attention-deficit hyperactivity disorder (ADHD). …”
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170
A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin
Published 2012-01-01“…Complexes between Aβ(1–16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu2+ is involved in Aβ(1–16) aggregation. …”
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171
Insulin in Central Nervous System: More than Just a Peripheral Hormone
Published 2012-01-01“…More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” …”
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172
Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reacti...
Published 2012-01-01“…Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mitochondrial ATP generation, redox state, transmembrane potential, and generation of reactive oxygen species (ROS) by the respiratory chain (RC), we developed a detailed kinetic model. …”
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173
Spines, Plasticity, and Cognition in Alzheimer's Model Mice
Published 2012-01-01“…The pathological hallmarks of Alzheimer's disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have been known for many decades, but the links between AD pathology and dementia and effective therapeutic strategies remain elusive. …”
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174
Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review
Published 2022-07-01“…Alzheimer's disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role of caregivers. …”
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175
Examining vaccination-related adverse events in frequent neurodegenerative diseases
Published 2025-02-01“…This study investigates adverse events following vaccination in patients with four neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Multiple Sclerosis (MS), and Parkinson's disease. …”
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176
Specificity of Cognitive Impairment in Neurological Disease: A Methodological Critique of Parkinson’s Disease
Published 1991-01-01“…Sometimes, a relationship has been established between certain cognitive deficits and particular neurochemical deficits which has led to the notion of specific drug treatment, e.g. cholinergic deficits and memory failure in Alzheimer's disease. However, these conclusions are often potentially flawed by methodological inadequacies. …”
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177
SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia
Published 1997-01-01“…We examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed significantly lower perfusion in frontal inferior and temporal inferior areas as compared to controls, both demented groups showed significantly more severe bilateral hypoperfusion in superior frontal, superior temporal and parietal areas as compared to non-demented PD patients and controls. …”
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178
Hsp70 and Its Molecular Role in Nervous System Diseases
Published 2011-01-01“…Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis). …”
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179
HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses.
Published 2025-02-01“…These methods find that systemic lupus erythematosus genes predominantly function in myeloid cells, and Alzheimer's disease genes mainly play roles in inhibitory and excitatory neurons. …”
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180
Medical-Surgical Nursing : assessment and management of clinical problems /
Published 2011Table of Contents: “…V. 2 -- Gastrointestinal system -- Nutritional problems -- Obesity -- Upper gastrointestinal problems -- Lower gastrointestinal problems -- Liver, pancreas, and biliary tract problems -- Urinary system -- Renal and urologic problems -- Acute kidney injury and chronic kidney disease -- Endocrine system -- Diabetes mellitus -- Endocrine problems -- Reproductive system -- Breast disorders -- Sexually transmitted diseases -- Female reproductive problems -- Male reproductive problems -- Nervous system -- Acute intracranial problems -- Stroke -- Chronic neurologic problems -- Alzheimer's disease, dementia, and delirium -- Peripheral nerve and spinal cord problems -- Musculoskeletal system -- Musculoskeletal trauma and orthopedic surgery -- Musculoskeletal problems -- Arthritis and connective tissue diseases -- Critical care -- Shock, systemic inflammatory response syndrome, and multiple organ dysfunction syndrome -- Respiratory failure and acute respiratory distress syndrome -- Emergency, terrorism, and disaster nursing -- Appendixes A: Cardiopulmonary resuscitation and basic life support for health care providers -- Appendixes B: Nursing diagnoses -- Appendixes C: Laboratory references intervals.…”
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