Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF mut papillary thyroid cancer with decreased liver toxicity by Shuai Xu, Qi Liang, Hang Li, Hai Zhou, Zhenyuan Xu, Yanjun Yan, Yue Zhang, Renqun Ye, Xujun You

“…Abstract Background Diosbulbin B (DB) is a traditional Chinese medicine used for thyroid cancer treatment, but always brings severe liver injury. In the current study, we investigated the role of astragalus polysaccharide (APS) in DB-induced hepatotoxicity and their anti-tumor effect on BRAF mut papillary thyroid cancer (PTC), and disclosed the underlying mechanisms. …”
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Antipyretic action of the new hydrazides 2 - (5 - (adamantane-1-yl)-4-r-1 ,2,4-triazol-3-ylthio)acetate by E. S. Pruglo, V. М. Оdintsova, А. А. Safonov

“…Despite the high efficacy of analgesics, antipyretics, their use is not always safe. Therefore, the search for new highly efficient drug with antipyretic action is an urgent problem nowadays. …”
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Controllable synthesis of alumina nanofibers with tunable crystal phases via a facile and cost-effective dealloying process by Qianwen Sun, Zhenying Huang, Wenqiang Hu, Haozheng Han, Weici Zhuang, Xue Li, Youbo Wu, Xinkang Li, Ziqiang Zhu, Yang Zhou

“…However, the scalable production of Al2O3 nanofibers has always faced significant challenges, namely, high cost and complicated processes. …”
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Treatment of waste marine clay by alkaline-activated ground granulated blast-furnace slag and municipal solid waste incineration bottom ash by Saiou Fu, Ping Wang, Shiyu Liu, Qianshen Ding, Lei Lang, Lijun Han, Xin Chen, Jiangshan Li

“…However, the engineering performance and durability of roadbed materials prepared from WMC have always been a concern for scholars and engineers. …”
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Early versus delayed interventions for necrotizing pancreatitis: A systematic review and meta‐analysis by Yousuke Nakai, Hideyuki Shiomi, Tsuyoshi Hamada, Shogo Ota, Mamoru Takenaka, Takuji Iwashita, Tatsuya Sato, Tomotaka Saito, Atsuhiro Masuda, Saburo Matsubara, Keisuke Iwata, Tsuyoshi Mukai, Hiroyuki Isayama, Ichiro Yasuda

“…Abstract Objectives Interventions for necrotizing pancreatitis are generally postponed until 4 weeks after the onset of acute pancreatitis, but there remains controversy about whether we should always wait >4 weeks or can intervene early when necessary. …”
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International festival-workshop of film schools “Kinoproba”: From a local city event to a large-scale one. (Physiological essay) by Liliya M. Nemchenko

“…Since creative industries are always connected with commercial and legal discourse, the article draws attention to the economic and legal aspects of the festival (financing, contracts with studios and authors, etc.). …”
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Reducing peak thermo-electricity energy demand in building: Insights from sensible and latent storage – Applicable in hot and arid regions by Wajdi Rajhi, Noreen Izza Arshad, Naoufel Kraiem, Ahmed Mir, Lioua Kolsi, Ahmad H. Milyani, Mohammed N. Ajour, Hesham A. Alhumade, Aliakbar Karimipour

“…In hot and desert regions, buildings have a considerable share in electricity consumption, so supplying electricity in critical hours for building cooling is always challenging for the electricity supply grid. …”
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ASSESSMENT OF CITIZENS'AWARENESS REGARDING ORAL HYGIENE AND PREVENTION OF DENTAL DISEASES by L.F. Kaskova, O.S. Pavlenkova, M.O. Sadovski, L.I. Amosova

“…respondents answered as follows: 42% of young people always pay attention to the composition, twice as many people - buy what the dentist advises, and the rest respondents were not interested in the components of the paste. …”
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Features of Cerebral Hemorrhage in the Victims of Peaceful Territory and Fighters of the Operation of the Combined Forces – of the Antiterrorist Operation After Traumatic Brain Inj... by V. Shevaga, M. Semchyshyn, B. Zadorozhna, A. Zadorozhny

“…The severity of the injury is not always associated with the degree of changes in blood flow, but the incidence and mortality from cerebrovascular lesions increase after trauma received during hostilities, because the vascular system of the brain is too sensitive to mechanical influences and different energies (light, sound, temperature, electromagnetic), which are released during the explosions of mines or shells. …”
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Quantitation of polysorbate 80 in recombinant protein formulation using high-performance liquid chromatography by A. D. Askretkov, D. O. Shatalov, N. V. Orlova, D. I. Zybin, V. V. Nikolaeva, A. A. Klishin, E. S. Tuzova, D. S. Minenkov, S. A. Kedik, Yu. A. Seregin

“…Polysorbate 80 (PS80) quantification in biopharmaceutical products has always been challenging owing to its minute content, absorption to the protein backbone, lack of specific chromophoric PS80 groups, and heterogenic nature. …”
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Retalho supramaleolar de fluxo reverso: aplicações clínicas Supramalleolous flap of reverse flow: clinical applications by Juliano Candido Batista

“…In the past, with intermediate transfer flaps were used, as the leg cross, are still with major drawbacks: they rely on more than one occasion, generate a lot of discomfort to the patient and are not always effective. Microsurgery has become an option that helps a lot to cover injuries this point, however, depends on the team with training and specialized equipment. …”
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Fish keypoint detection for offshore aquaculture: a robust deep learning approach with PCA-based shape constraint by Gen Li, Gen Li, Anji Lian, Zidan Yao, Yu Hu, Yu Hu, Guoliang Pang, Guoliang Pang, Taiping Yuan, Taiping Yuan, Zhenhua Li, Xiaohua Huang, Xiaohua Huang, Gang Wang

“…As a result, output keypoints of such networks do not always conform to the shape of a fish and the training process can be affected by incorrect labels, leading to errors in subsequent tasks.MethodsTo address these issues, this paper proposes a robust deep learning approach characterized by three improvements. 1) A shape model of fish that includes the average shape of fish, principal components of fish keypoints, and corresponding eigenvalues is constructed using principal component analysis (PCA) and unscented transform. 2) A customized version of anchor boxes is introduced and referred to as “anchor fish”, which along with the shape model, can be used to encode and decode fish keypoints. 3) Shape variation loss, calculated based on the eigenvalues in the shape model, is added as part of the loss function to constrain the output of the regression head. …”
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Current status of Botryosphaeriaceae species in Italy: Impacts on agricultural crops and forest ecosystems by Dalia AIELLO, Carlo BREGANT, Antonia CARLUCCI, Vladimiro GUARNACCIA, Giorgio GUSELLA, Benedetto Teodoro LINALDEDDU, Laura MUGNAI, Maria Luisa RAIMONDO, Giancarlo POLIZZI

“…Preventive detection and adequate control strategies are always needed to limit the potential damage caused by Botryosphaeriaceae. …”
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Visual film myths of the soviet era in the ideological creation of a "new" person / Визуальные киномифы советской эпохи в идеологическом созидании «нового» человека... by Sergey Malenko / Маленко Сергей Анатольевич, Andrey Nekita / Некита Андрей Григорьевич

“…The film-mythological actualization of the archetypal essence of the Soviet man always asserted the priority of the spiritual over the material. …”
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Examining the Effects of Construction Project Delays on Costs from the Perspective of Stakeholders Using a System Dynamics Approach: Insights from a Commercial Complex Project in Q... by Amirhosein Saffarinia, Hamidreza Yazdani

“…This study confirmed that delays are almost always costly. However, their impact depends on the managers’ mindset and project conditions. …”
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Geometric characteristics of bicuspid aortic valvesCentral MessagePerspective by Jan Nijs, MD, Babs Vangelder, MD, Kaoru Tanaka, MD PhD, Sandro Gelsomino, MD, PhD, FESC, Ines Van Loo, MD, Mark La Meir, MD, PhD, Jos Maessen, MD, PhD, Bas L.J.H. Kietselaer, MD, PhD

“…The position of the raphe can vary and is not always situated in the middle of the free edge. The position of the right/non commissure is variable, whereas the right/left commissure is more fixed.…”
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Harnessing Multiscale Topographic Environmental Variables for Regional Coral Species Distribution Models by Annie S. Guillaume, Renata Ferrari, Oliver Selmoni, Véronique J. L. Mocellin, Hugo Denis, Melissa Naugle, Emily Howells, Line K. Bay, Stéphane Joost

“…Interestingly, variables at the finest resolution (15 m) were not always the most relevant for producing accurate coral SDMs, with optimal resolutions between 15 and 60 m depending on the variable type and species. …”
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The distributions of the gladiator frogs (Hyla boans group) in Colombia, with comments on size variations and sympatry by Lynch John Douglas, Suárez Mayorga Angela M.

“…Hyla pugnax occurs across the Caribbean lowlands and up the Magdalena valley as well as in the Maracaibo Basin and at a few cis-Andean sites, but always below 500 m. Sympatry is relatively common between H. boans and H. rosenbergi but, less common between H. boans and either "H. crepitans" or H. pugnax. …”
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A novel framework for analyzing rainy season dynamics in semi-arid environments: a case study in the Peruvian Rio Santa basin by L. Hänchen, E. Potter, C. Klein, P. Calanca, F. Maussion, W. Gurgiser, G. Wohlfahrt

“…However, these metrics based on precipitation time series do not always accurately reflect plant water availability, and the variety of available metrics can complicate the selection of the most suitable one. …”
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Therapeutic Anticoagulant Does not Modify Thromboses Rate Vein after Venous Reconstruction Following Pancreaticoduodenectomy by Mehdi Ouaïssi, Igor Sielezneff, Nicolas Pirro, Rémi Bon Mardion, Jean Batiste Chaix, Abdelrhame Merad, Stéphane Berdah, Vincent Moutardier, Silvia Cresti, Olivier Emungania, Loundou Anderson, Brunet Christian, Sastre Bernard

“…Curative anticoagulant treatment was always indicated after type IV (n=2) resection, and after resection of type II when the length of venous resection was longer than ≥2 cm. …”
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