EDITORIAL by Ivan Čuk

“…Your comments on any of the published articles or any queries you might have are also always welcome. The Editorial Board wishes you a good reading. …”
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Automatic melanoma and non-melanoma skin cancer diagnosis using advanced adaptive fine-tuned convolution neural networks by Muhammad Amir Khan, Tehseen Mazhar, Muhammad Danish Ali, Umar Farooq Khattak, Tariq Shahzad, Mamoon M. Saeed, Habib Hamam

“…Traditionally approaches have High computational costs, a lack of interpretability, deal with numerous hyperparameters and spatial variation have always been problems with machine learning (ML) and DL. …”
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Parental involvement of immigrant parents in early educational centers and its relationship with intercultural sensitivity by Marian Bilbao, Florencia Guglielmetti-Serrano, María José Mera-Lemp, José J. Pizarro, José J. Pizarro, Denisse Fernandez, Gonzalo Martínez-Zelaya

“…Among facilitators, a positive climate among parents increased the odds of always participating, while the presence of other immigrant families in school paradoxically correlated with lower involvement. …”
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Evaluation of the Quality of Delirium Website Content for Patient and Family Education: Cross-Sectional Study by Karla Krewulak, Kathryn Strayer, Natalia Jaworska, Krista Spence, Nadine Foster, Scotty Kupsch, Khara Sauro, Kirsten M Fiest

“…While most delirium-related website content generally meets quality standards based on DISCERN and JAMA benchmark criteria, high scores do not always ensure patient and family-friendliness. Many of the top-rated delirium content were text-heavy and complex in layout, which could be overwhelming for users seeking clear, concise information. …”
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Comparison of tea tree oil 5%, tea tree oil 10%, and nystatin inhibition zones against vaginal Candida isolates in pregnancy by Evy Ervianti, Damayanti, Indah Purnamasari, Linda Astari, Budi Prasetyo, Pepy D Endraswari, Budi Utomo, Endang Wahyu Fitriani, Diah Mira Indramaya, M Yulianto Listiawan, Cita Rosita Sigit Prakoeswa

“…Clinical study suggests that conventional topical treatments for VVC are not always enough to eradicate Candida spp. from the vaginal microenvironment. …”
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THE RCEP ECONOMIES AMID GLOBAL TURBULENCE by Svitlana Radziyevska

“…Practical implications. East Asia has always been one of the most contested regions of the world where the interests of the global players intersect; however, the prosperity at present requires not only the reconsideration of the lessons learned in the past, but primarily implies the transformation from competition to collaboration – the imperative for peaceful coexistence in future for all. …”
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Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies by Cristina Ferreira Almeida, Andreia Palmeira, Maria João Valente, Georgina Correia-da-Silva, Anne Marie Vinggaard, Maria Emília Sousa, Natércia Teixeira, Cristina Amaral

“…Due to key estrogen signaling, estrogen receptor-positive (ER⁺) breast cancer treatment has always been focused on aromatase inhibition and ER modulation. …”
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The association between aldosterone and lipid profiles in patients with primary aldosteronism by Ning-Peng Liang, Kun-Rui Rao, Ming Hu, Ru-Yi Bao, Jian-Wei Liu, Ze-Qun Lai, Hong-Jin Zhang, Huang Zhang, Meng-Bo Wu, Xiang-Tao Zhang, Yi-Fei Dong

“…However, the above associations were not always present in clinically matched EH patients.…”
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IMPLEMENTASI PENGUATAN PENDIDIKAN KARAKTER (PPK) DI MADRASAH IBTIDAIYAH by Ummu Jauharin Farda

“…Somethings that can be recommended to relevant parties include: (1) Semarang city government in this case the City Ministry of Religion should socialize Perpres No. 87 of 2018 related to strengthening character education and conducting socialization as well as mentoring. (2) The school is always pro-active and cooperates between schools who already know the information and implementation related to Presidential Regulation No.87 of 2018 concerning strengthening character education. …”
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CLINICAL STUDIES OF MATERIALS FOR TEMPORARY REMOVABLE PROSTHESIS by O.S. Kyrmanov

“…Declared in dental literature light curing mechanical properties of composite materials and dual-curing is not always supported by the inconvenience for manual processing. …”
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Establishing an objective decision criterion for intraocular lens exchange due to homogeneous calcification: a prospective clinical analysis by Timur M. Yildirim, Grzegorz Łabuz, Nikola Henningsen, Hyeck-Soo Son, Victor A. Augustin, Leoni Britz, Lizaveta Chychko, Ramin Khoramnia, Gerd U. Auffarth

“…Conclusion Homogeneous IOL calcification is not always associated with a pronounced reduction in visual acuity. …”
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Assessment of knowledge, attitude & practice of biomedical waste management among junior doctors during COVID-19 pandemic in a medical college & hospital of Eastern India by Hasina Banu, Swarnava Pramanick, Sinjita Dutta, Kumkum Bhattacharyya, Hirak Jyoti Raj

“…Assessment of attitude was accomplished by ‘five-point Likert’s scale’ and that of practice by answers like ‘never’, ‘sometimes’ and ‘always’ against preset questions. The data were analysed using Statistical Package for Social Sciences (SPSS) software. …”
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TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1‐Mediated Neuronal PANoptosis in Spinal Cord Injury by Junsheng Lou, Yiting Mao, Wu Jiang, Honghao Shen, Yunpeng Fan, Qing Yu, Conghui Zhou, Ziyao Wei, Kailiang Zhou, Mengran Jin, Junsong Wu

“…Abstract Spinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis after injury. …”
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The impact of soil data on SWAT modeling: Effects, requirements, and future directions by Yassine Bouslihim, Mohamed Ouarani, Soufiane Taia, El Mahdi El Khalki, Abdessamad Hadri, Mohamed Hakim Kharrou, Abdelghani Chehbouni

“…Key results show that: (1) the choice of global soil dataset minimally affects streamflow simulations, especially for monthly time steps and large-scale catchments, though different datasets often require distinct parametrizations to achieve similar performance; (2) for sediment and nutrient transport simulations, soil data selection becomes crucial for model accuracy; and (3) the relationship between soil data resolution and model performance is not linear, with high-resolution data not always guaranteeing better results. This review identifies critical research gaps, including the need to: understand dynamic soil conditions, explore SWAT's sensitivity to temporal resolutions, refine global soil datasets, and investigate groundwater flow dynamics. …”
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Exploring the SARS-CoV-2 spike protein destabilizer toxin from the scorpion, spider, and wasp group of toxins as a promising candidate for the identification of pharmacophores agai... by Mousa O. Germoush, Maged Fouda, Mohammad J. S. Mantargi, Moustafa Sarhan, Barakat M. AlRashdi, Diaa Massoud, Ahmed E. Altyar, Mohamed M. Abdel-Daim

“…Therefore, developing more potent medications is always a primary goal. Finding more effective drugs is a top priority. …”
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Agent-Based Adaptive Dynamic Round Robin (AADRR) Scheduling Algorithm by Zafar Iqbal Khan, Muzafar Khan, Syed Nasir Mehmood Shah

“…AADRR efficiently reduces average turnaround times and average waiting times for each workload and performs better in response time. AADRR may not always provide the most favorable measures in all scenarios. …”
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Nutrients and Quality Aspects Characterizing <i>Ostrea edulis</i> Cultivated in Valli di Comacchio (Northern Italy) Across Different Seasons by Francesco Chiefa, Paola Tedeschi, Mirco Cescon, Valentina Costa, Elena Sarti, Manuel Salgado-Ramos, Noelia Pallarés, Natasha Damiana Spadafora, Leonardo Aguiari, Luisa Pasti

“…Contaminant levels were always below the imposed concentration limits; however, higher levels of toxic metals were detected in the winter, while polycyclic aromatic hydrocarbons were detected in the summer and autumn. …”
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Clinical Characteristics and Risk Factors for Severity and Prognosis of Convulsive Status Epilepticus by Zhen Tian, Yingchun Xu, Rundong He, Di Huang, Wanyu Liu, Peiwen Li, Jiasheng Yang, Jie Yang, Jing Ding, Wei Yue

“…ABSTRACT Background Convulsive status epilepticus (CSE) is a frequently encountered serious condition in the field of neurology. Research on CSE has always been a key issue in the field of neurological emergencies. …”
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The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing by Tezenas, Emilie, Giraud, Tatiana, Véber, Amandine, Billiard, Sylvain

“…We found that the presence of a fungal-like mating-type locus (i.e. not preventing diploid selfing) always sheltered the mutation under selfing, i.e. it decreased the purging probability and increased the purging time of the mutations. …”
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Method of Entry Layout under Synergistic Effects of Abutment Stress and Dynamic Stress by Wenlong Shen, Guocang Shi, Meng Wang, Tenglong Rong, Yungang Wang, Ruifeng Zhang, Xiangyu Wang, Jianbiao Bai

“…In underground mining engineering, rocks around the entry are always subjected to large plastic deformation disasters, such as supporting body failure, roof rock collapse, and even rock burst under abutment stress and dynamic stress. …”
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