GABA dysfunction in schizophrenia: The GABAA receptor as a potential therapeutic target by Brandon L.M. Crotchett, Seth D. Reighard, Henry A. Nasrallah

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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

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Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments by Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar

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Prospects for the use of allosteric drugs in real-world clinical practice by I. R. Svechkareva, A. S. Kolbin

Subjects: “…allosteric modulation…”
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Distinct potency of compounds targeting the T1R3 subunit in modulating the response of human sweet and umami taste receptors by Maiko Kawasaki, Yuta Kidera, Ryusei Goda, Chiaki Taketani, Misato Ide, Wataru Fujii, Tomoya Nakagita, Takumi Misaka

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Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor by Santiago Stabile, Juan Facundo Chrestia, Gabriel Radivoy, Cecilia Bouzat

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Further In Vitro and Ex Vivo Pharmacological and Kinetic Characterizations of CCF219B: A Positive Allosteric Modulator of the α_1A-Adrenergic Receptor by Robert S. Papay, Dianne M. Perez

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Positive allosteric regulation of PAC1-R up-regulates<?A3B2 ACK?>PAC1-R and its specific ligand PACAP by Fan Guangchun, Tao Zhengxin, Chen Shang, Zhang Huahua, Yu Rongjie

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Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system by Christian Böhm, Anna-Lena Wiessler, Dieter Janzen, Julian Nausester, Benedikt Slavik, Helene M. Loos, Carmen Villmann, Andrea Buettner

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Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide by César O. Lara, Carlos F. Burgos, Katherine Fariña-Oliva, Ana M. Marileo, Victoria P. San Martín, David Flaig, Paul Soto-Ortega, Omayra V. Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A. Castro, Luis G. Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E. Yévenes

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Allosteric activators of cystathionine γ lyase to augment endogenous hydrogen sulfide and inhibit pathologic calcification by Sonia Nasi, Driss Ehirchiou, Cindy Blatter, Veronique Chobaz, Stefan Germann, Alexandra Brandenberger, Elias Bommeli, Emiko Uchikawa, Giuseppe Cirino, Rainer Riedl, Alexander So, Nathalie Busso

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Progress in GABAA receptor agonists for insomnia disorder by Weiyi Wang, Wanting Fu, Hongyan Zhu, Jing Ma, Jian Zhang, Jia Qi

Subjects: “…partial positive allosteric modulator…”
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GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases by Weijie Xie, Yuan Li, Xinyue Wang, Elena Blokhina, Evgeny Krupitsky, Marina Vetrova, Ji Hu, Ti‐Fei Yuan, Jue Chen, Hua Wang, Xiangfang Chen

Subjects: “…allosteric modulator…”
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Small molecule protein assembly modulators with pan-cancer therapeutic efficacy by Anuradha F. Lingappa, Olayemi Akintunde, Erin Samueli, Connie Ewald, Maya Michon, Niloufar Ziari, Ming Lu, Shao Feng Yu, Markus Froehlich, Phuong Uyen Le, Yuniel Fernandez, Suguna Mallesh, Jim Lin, Anatoliy Kitaygorodskyy, Dennis Solas, Jonathan C. Reed, Jaisri R. Lingappa, Andreas Müller-Schiffmann, Carsten Korth, Dharma Prasad, Aysegul Nalca, Emily Aston, Brad Fabbri, Sanjeev K. Anand, Thomas W. Campi, Emma Petrouski, Debendranath Dey, David W. Andrews, James L. Rubenstein, Vishwanath R. Lingappa

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Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer’s disease: a single ascending-dose stud... by Alexander C. Conley, Alexandra P. Key, Jennifer U. Blackford, Jason K. Russell, Kimberly M. Albert, Xuewen Gong, Michael Bubser, Jerri M. Rook, P. Jeffrey Conn, Craig W. Lindsley, Carrie K. Jones, Paul A. Newhouse

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Valerenic Acid and Pinoresinol as Positive Allosteric Modulators: Unlocking the Sleep-Promoting Potential of Valerian Extract Ze 911 by Roman Senn, Lukas Schertler, Hendrik Bussmann, Juergen Drewe, Georg Boonen, Veronika Butterweck

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Synthesis and Evaluation of a Novel Zuranolone Analog with High GABA_A Receptor PAM Activity and Excellent Pharmacokinetic Profiles by Yingjie Yang, Xu Deng, Hengwei Xu, Daoyuan Chen, Fengjuan Zhao, Huijie Yang, Wenyan Wang, Chunjie Sha, Mingxu Ma, Guanqing Zhang, Liang Ye, Jingwei Tian

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Calcium-Sensing Receptor as a Novel Target for the Treatment of Idiopathic Pulmonary Fibrosis by Kasope Wolffs, Renjiao Li, Bethan Mansfield, Daniel A. Pass, Richard T. Bruce, Ping Huang, Rachel Paes de Araújo, Bahareh Sadat Haddadi, Luis A. J. Mur, Jordanna Dally, Ryan Moseley, Rupert Ecker, Harry Karmouty-Quintana, Keir E. Lewis, A. John Simpson, Jeremy P. T. Ward, Christopher J. Corrigan, Renata Z. Jurkowska, Benjamin D. Hope-Gill, Daniela Riccardi, Polina L. Yarova

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The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice by Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesca Rosso, Ilaria Musante, Silvana Alfei, Maria Cerminara, Aldamaria Puliti, Gilberto Filaci, Daniela Fenoglio, Riccardo Leardi, Ernesto Fedele, Giambattista Bonanno, Marco Milanese, Tiziana Bonifacino

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