An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease by Brooke McMinn, Alicia L. Duval, Christie M. Sayes

“…Adverse outcome pathways (AOPs) are pragmatic tools in human health hazard characterization and risk assessment. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

Subjects: “…Adverse outcome pathway (AOP)…”
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Temperature-dependent toxicity and mechanisms of florfenicol on the embryonic development of marine medaka (Oryzias melastigma) by Xingying Guo, Xu Gong, Jinhui Wang, Tan-Duc Nguyen, Syed Shabi Ul Hassan Kazmi, Jiezhang Mo, Feng Hua, Wenhua Liu, Zhen Wang

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Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set enrichment analysis by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…Next, we developed a global adverse outcome pathway (AOP) network based on the existed AOP-wiki. …”
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DRomics, a workflow to exploit dose-response omics data in ecotoxicology by Delignette-Muller, Marie Laure, Siberchicot, Aurélie, Larras, Floriane, Billoir, Elise

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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…Comprehensive understanding of the precise mode of action/adverse outcome pathway (MoA/AOP) of chemicals becomes a key step towards superseding the current repeated dose toxicity testing methodology with new generation predictive toxicology tools. …”
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Responses of an <i>In Vitro</i> Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens^®) Following Exposure to Skin Sensitizers and Non-Sensitiz... by Sabina Burla, Aline Chary, Tommaso Serchi, Sébastien Cambier, Kristie Sullivan, Elizabeth Baker, Nikaeta Sadekar, Arno C. Gutleb

“…While the process of skin sensitization is well characterized through the adverse outcome pathway (AOP) framework, the immunological mechanisms underlying respiratory sensitization remain less well understood. …”
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Evaluating the toxicity of sea-dumped conventional and chemical munition degradation products to fish and human cells using a combination of cell viability assays by João Barbosa, Colin R. Janssen, Marijke Neyts, Koen Parmentier, Frédéric Laduron, Kris Geukens, Philippe François, Jana Asselman

“…The study also reveals inter-species and inter-organ variability in toxicity mechanisms, identifying potential adverse outcome pathways such as AOP 220. These findings highlight the need for further research into chronic exposure scenarios at environmentally realistic concentrations and contribute crucial data to understanding the risks posed by the degradation products of these chemicals to aquatic life and human health.…”
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