Role of Social Factors in Social Economic Status of Families in Kabale Municipality Kabale District. by Atukunda, Brian

“…., the results of the study have revealed that some conciliators do not know the law related to inheritance and succession, that is why we recommend them to learn that law and other rules and regulation in force in the country; the findings of the study have proven that some conciliators are biased, so we recommend them to be impartial in order to mediate parts on family based conflicts caused by alcohol up take fairly and the study concluded that it has been revealed by the findings that social factors have a negative impact on economic prosperity of families where dealing with these alcoholic beverages bring about spending and consumes time that could be devoted in generating income activities. This slows down family income, and agricultural productivity and reduces agricultural employment especially when land is portioned into small parts. …”
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Factors Affecting Teachers in Implementing the Thematic Curriculum in Primary Schools in Uganda: A Case Study of Butogota Primary School Kanungu District. by Twinomujuni, Dorothy

“…The findings showed that on factors affecting teachers in implementing the thematic curriculum, the majority of the respondents 60% mentioned thematic curriculums can feel prescriptive as factors affecting teachers in implementing thematic curriculum, it was also found that the majority of respondents 45% of teachers face challenges in implementing thematic curriculums, which often require a variety of engaging materials and activities and the majority 23% of respondents mentioned advocating for teachers to work together in developing thematic units and sharing resources as possible solutions to the challenges facing teachers in implementing the thematic curriculum. …”
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Provision of Managerial Skills by Micro Credit Institutions and Sustainability of MSMEs During COVID-19 Pandemic in Kigezi Region South Western Uganda by Kyabarongo, Benon, Moses, Agaba, Siraje, Kaaya

“…Enterprises' owners and managers were the units of inquiry due to their importance as custodians of information on all the activities taking place in their respective MSMEs. The research population was separated into clusters (areas or districts) and the appropriate sample was recruited using simple random sampling. …”
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Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa by Keneth Iceland, Kasozi, Zirintunda, Gerald, Ssempijja, Fred, Buyinza, Bridget, Alzahrani, Khalid J., Matama, Kevin, Nakimbugwe, Helen N., Alkazmi, Luay, Onanyang, David, Bogere, Paul, Ochieng, Juma John, Islam, Saher, Matovu, Wycliff, Nalumenya, David Paul, Batiha, Gaber El-Saber, Osuwat, Lawrence Obado, Abdelhamid, Mahmoud, Shen, Tianren, Omadang, Leonard, Welburn, Susan Christina

“…African animal trypanosomiasis (AAT) affects both livestock and wildlife carrying a significant risk of spillover and cross-transmission of species and strains between populations. Increased human activity together with pressure on land resources is increasing wildlife–livestock–human infections. …”
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model by Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni

“…Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage. Neutrophil activation is part of the dysregulated immune response to infection defining sepsis and neutrophil elastase is one of the powerful proteases causing both effects and damage. …”
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Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UP... by Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang

“…These results suggest that proteins harboring OBI-related mutations may tend to accumulate in the ER, thereby triggering an ERS response and impairing the transcription and translation of HBsAg via the activation of the unfolded protein response and ER-associated protein degradation pathway. …”
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Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…RelA signaling upregulated the expression of activating transcription factor 4 and glucose-regulated protein 78, thereby alleviating ER stress. …”
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Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…Therefore, we aimed to suppress the pro-inflammatory activity of M1-like macrophages and decrease their infiltration at the site of inflammatory insult to resolve tissue inflammation. …”
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Photon sensor-based monitoring of spatial variations in canopy FIPAR for crop growth assessment by Jian Wang, Zhenggui Zhang, Xin Li, Lu Feng, Xiaofei Li, Minghua Xin, Shiwu Xiong, Yingchun Han, Shijie Zhang, Xiaoyu Zhi, Beifang Yang, Guoping Wang, Yaping Lei, Zhanbiao Wang, Yabing Li

“…The photon sensor-based fraction of intercepted photosynthetically active radiation (FIPAR) monitoring system was demonstrated to provide accurate real-time tracking of crop growth. …”
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Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy? by Gloria P. Vergara-Diaz, Stefano Sapienza, Jean-François Daneault, Eric Fabara, Catherine Adans-Dester, Giacomo Severini, Vincent C. K. Cheung, Carmen Echevarría Ruiz de Vargas, Donna Nimec, Paolo Bonato

“…Linear mixed effect models showed that composition of the muscle synergies and their temporal activation coefficients present deviations from normative data proportional to the severity of functional limitations (i.e., GMFCS levels, p < 0.01). …”
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Morphological features of autoimmune gastritis by Ye. A. Losik, L. S. Selivanova, M. Yu. Konkov, T. L. Lapina, A. S. Tertychnyi, V. T. Ivashkin

“…In 3 cases non-metaplastic variant of patchy atrophic gastritis was present, the rest revealed superficial gastritis with signs of activity in 4 cases. No Н. рylori was found out morphologically.Conclusion. …”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…It was verified that high EDF1 expression in NB cells led to Lactosylceramide (LacCer) accumulation, as well as downstream ganglioside-GD3, which subsequently increased the expression of CD52 and immune checkpoint genes, chemotaxis, and apoptosis-related events in activated CD8+T cells. Mechanistically, EDF1 was recruited as a coactivator to form the NF-κB/RelA/EDF1 complex, which further prevented the promoter region methylation of ST8SIA1, to elevate its transcription. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Lastly, in vitro experiments were performed for validation.ResultsA least of four key targets, namely BCL2 apoptosis regulator (BCL2), estrogen receptor 1 (ESR1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and signal transducer and activator of transcription 3 (STAT3) were identified in this study, and molecular docking analyses revealed that SSA stably binds to these targets. …”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…In routine clinical practice PEI is diagnosed mainly on the basis of decreased pancreatic enzymes activity in stool in patients with verified pancreatic disease but can result in decreased exocrine function. …”
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Exploring mental health in veterinary students: common stressors and effective coping strategies: a narrative review by Rahib K. Islam, Emily K. Cobb, Hannah K. McCowan, Kylie Watson, Kaustuv Bhattacharya, Kaustuv Bhattacharya, Anjali Chandra, Warda Mohiuddin, Karen Gruszynski, Karen Gruszynski, Amanda H. Wilkerson, John J. Dascanio, Robert E. Davis, Vinayak K. Nahar, Vinayak K. Nahar

“…Effective coping strategies included exercise and social activities; whereas, harmful behaviors like substance misuse exacerbated mental health issues. …”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…The provision of appropriate timely health prevention, promotion and monitoring activities to reduce these health inequalities are needed, especially in deprived areas.…”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…The ArcA transcription factor activates genes related to metabolism, membrane permeability, and virulence, and its presence is required for pathogenicity in Salmonella Typhimurium, which can be phosphorylated independently of its cognate sensor, ArcB. …”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…Using an 8 % high-salt diet model, we evaluated the effects of Kae (200 mg/kg/day) in wild-type (WT) and activating transcription factor 4 (ATF4+/−) knockout mice. …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…No significant elevation of alanine transaminase and aspartate aminotransferase activity, or bilirubin level were detected. Conclusions. …”
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Variability and Source Characterization of Regional PM of Two Urban Areas Dominated by Biomass Burning and Anthropogenic Emission by Christian Mark G. Salvador, Jhon Robin dR. Yee, Iara Chantrelle V. Coronel, Angel T. Bautista, Raymond J. Sugcang, Mark Anthony M. Lavapiez, Rey Y. Capangpangan, Preciosa Corazon B. Pabroa

“…For Boracay, the mixed contributions of BB and vehicular activities influenced the formation of PM. Overall, the reanalysis of satellite data captured the long-term variability and origins of surface PM in two vital urban regions in the Philippines. …”
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