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  1. 441

    Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

    Published 2025-02-01
    “…The bacterial growth rate remained largely unchanged after the phage resistance mutation, but mice infected with the mutant strain showed significantly higher survival rates than those infected with the wild-type strain. vB_Kpn_HF0522 increased the survival rate of infected G. mellonella from 12.5% to 75%, inhibited incisional surgical site infections and alleviated inflammatory response in mice.Conclusion: These findings indicate that vB_Kpn_HF0522 has significant potential for treating specific bacterial infections, and may serve as an antimicrobial agent for research and clinical anti-infective therapy.Keywords: phage vB_Kpn_HF0522, phage therapy, Klebsiella pneumoniae, phage resistance, incisional surgical site infection, biofilm…”
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  2. 442
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  4. 444

    Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

    Published 2025-03-01
    “…We applied these methods to evaluate condensation of the SARS-CoV-2 nucleocapsid (N) protein under GSK3 inhibitor treatment, which we had previously identified in our HCS campaign to induce condensation with well-defined structure-activity relationships (SAR). …”
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    Business Study Guide : BTEC Level 4 HNC and Level 5 HND in Business /

    Published 2011
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    Book
  8. 448

    Midwifery : Preparation for practice 5e / book 1.

    Published 2019
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    Book
  9. 449

    Midwifery : Preparation for practice 5e / book 2.

    Published 2019
    View in OPAC
    Book
  10. 450
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    Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

    Published 2020-10-01
    “…IRs (95% CI) for serious AEs, serious infections, herpes zoster (all), opportunistic infections (excluding tuberculosis [TB]) and TB were 9.0 (8.6 to 9.4), 2.5 (2.3 to 2.7), 3.6 (3.4 to 3.9), 0.4 (0.3 to 0.5) and 0.2 (0.1 to 0.2), respectively. …”
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  12. 452
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  14. 454

    Development and application of an efficient, accurate, and environmentally friendly liquid chromatography–tandem mass spectrometry method for the determination of five Alternaria toxins in wheat by Huiyuan Lang, Zengwang Guo, Yu Wu, Li Li, Hongmei Liu, Lianzhou Jiang, Songxue Wang, Jin Ye

    Published 2025-01-01
    “…This study developed a rapid, efficient, and environmentally friendly method for the simultaneous determination of five types of Alternaria toxins in wheat using high-precision and stable isotope liquid chromatography tandem mass spectrometry. …”
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  18. 458

    Improved SED-fitting Assumptions Result in Inside-out Quenching at z ~ 0.5 and Quenching at All Radii Simultaneously at z ~ 1 by Alexander de la Vega, Susan A. Kassin, Camilla Pacifici, Stéphane Charlot, Emma Curtis-Lake, Jacopo Chevallard, Timothy M. Heckman, Anton M. Koekemoer, Weichen Wang

    Published 2025-01-01
    “…We then perform radial SED fits to multiband flux profiles measured from Hubble Space Telescope images for 1440 galaxies at 0.4 <  z  < 1.5 of stellar masses 10 ^10 –10 ^11.5 M _⊙ using both the traditional and the more physically motivated assumptions. …”
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  19. 459

    Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling by Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D. Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck

    Published 2025-02-01
    “…Abstract Macrophages express numerous G protein-coupled receptors (GPCRs) that regulate adhesion, migration, and activation, but the function of orphan receptor GPRC5B in macrophages is unknown. Both resident peritoneal and bone marrow-derived macrophages from myeloid-specific GPRC5B-deficient mice show increased migration and phagocytosis, resulting in improved bacterial clearance in a peritonitis model. …”
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  20. 460

    Characterization of Seasonal Difference of HULIS-C Sources from Water Soluble PM2.5 in Seoul, Korea: Probing Secondary Processes by Hyung-Min Lee, Se Pyo Lee, Yugen Li, Jian Zhen Yu, Jin Young Kim, Yong Pyo Kim, Ji Yi Lee

    Published 2020-10-01
    “…In this study, we characterized the seasonal variation of HULIS-C (the carbon component of HULIS) and identified primary and secondary sources contributing to HULIS-C at an urban site in Seoul, Korea by analyzing 131 PM2.5 samples collected over a year from October 2012 to September 2013. …”
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