Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats.
Aluminium exposure has been linked with developmental neurotoxicity in humans and experimental animals.The study aimed to evaluate the ameliorative effect of Tamarindus indica on the developing cerebellar cortex, neurobehavior, and immunohistochemistry of the cerebellar cortex following prenatal alu...
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Kabale University
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/932 |
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| author | Usman, Ibe Michael Adebisi, Samuel Sunday Musa, Sunday Abraham Iliya, Ibrahim Abdullahi Archibong, Victor Bassey Lemuel, Ann Monima Keneth Iceland, Kasozi |
| author_facet | Usman, Ibe Michael Adebisi, Samuel Sunday Musa, Sunday Abraham Iliya, Ibrahim Abdullahi Archibong, Victor Bassey Lemuel, Ann Monima Keneth Iceland, Kasozi |
| author_sort | Usman, Ibe Michael |
| collection | KAB-DR |
| description | Aluminium exposure has been linked with developmental neurotoxicity in humans and experimental animals.The study aimed to evaluate the ameliorative effect of Tamarindus indica on the developing cerebellar cortex, neurobehavior, and immunohistochemistry of the cerebellar cortex following prenatal aluminum chloride (AlCl3) exposure. Pregnant timed Wistar rats were divided into 5 groups (n=4). Group I (negative control) was given distilled water, group II was treated with 200 mg/kg of AlCl3, group III were given 200 mg/kg of AlCl3 and 400 mg/kg of ethyl acetate leaf fraction of Tamarindus
indica (EATI), group IV were given 200 mg/kg of AlCl3 and 800 mg/kg of EATI, and group V were treated with 200 mg/kg of AlCl3 s/c and 300 mg/kg of vitamin E for 14 days (prenatal day 7–21) via the oral route. Male pups (n=6) were randomly selected and taken for neurobehavioral studies, and humanely sacrificed via intraperitoneal injection of thiopental sodium.
The cerebellum was removed, fixed and tissue processed for histological and immunohistochemical studies. The results revealed that prenatal AlCl3 exposure impacted neurodevelopment and neurobehaviour among exposed pups. Prenatal AlCl3 exposure was marked with delayed cytoarchitectural development of the cerebellar cortex and increased GFAP expression inthe cerebellar cortex. On the other hand, treatment with EATI and vitamin E were marked with significant improvements.The present study therefore concluded treatment with EATI shows an ameliorative effect to prenatal AlCl3 exposure.
Key words: Tamarindus Indica, Glial Fibrillary Protein, Motor Cordination, Aluminum Exposure |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-932 |
| institution | KAB-DR |
| language | en_US |
| publishDate | 2023 |
| publisher | Kabale University |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9322024-01-17T04:45:13Z Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. Usman, Ibe Michael Adebisi, Samuel Sunday Musa, Sunday Abraham Iliya, Ibrahim Abdullahi Archibong, Victor Bassey Lemuel, Ann Monima Keneth Iceland, Kasozi Tamarindus Indica Glial Fibrillary Protein Motor Cordination Aluminum Exposure Aluminium exposure has been linked with developmental neurotoxicity in humans and experimental animals.The study aimed to evaluate the ameliorative effect of Tamarindus indica on the developing cerebellar cortex, neurobehavior, and immunohistochemistry of the cerebellar cortex following prenatal aluminum chloride (AlCl3) exposure. Pregnant timed Wistar rats were divided into 5 groups (n=4). Group I (negative control) was given distilled water, group II was treated with 200 mg/kg of AlCl3, group III were given 200 mg/kg of AlCl3 and 400 mg/kg of ethyl acetate leaf fraction of Tamarindus indica (EATI), group IV were given 200 mg/kg of AlCl3 and 800 mg/kg of EATI, and group V were treated with 200 mg/kg of AlCl3 s/c and 300 mg/kg of vitamin E for 14 days (prenatal day 7–21) via the oral route. Male pups (n=6) were randomly selected and taken for neurobehavioral studies, and humanely sacrificed via intraperitoneal injection of thiopental sodium. The cerebellum was removed, fixed and tissue processed for histological and immunohistochemical studies. The results revealed that prenatal AlCl3 exposure impacted neurodevelopment and neurobehaviour among exposed pups. Prenatal AlCl3 exposure was marked with delayed cytoarchitectural development of the cerebellar cortex and increased GFAP expression inthe cerebellar cortex. On the other hand, treatment with EATI and vitamin E were marked with significant improvements.The present study therefore concluded treatment with EATI shows an ameliorative effect to prenatal AlCl3 exposure. Key words: Tamarindus Indica, Glial Fibrillary Protein, Motor Cordination, Aluminum Exposure 2023-02-03T05:25:34Z 2023-02-03T05:25:34Z 2022 Article http://hdl.handle.net/20.500.12493/932 en_US application/pdf Kabale University |
| spellingShingle | Tamarindus Indica Glial Fibrillary Protein Motor Cordination Aluminum Exposure Usman, Ibe Michael Adebisi, Samuel Sunday Musa, Sunday Abraham Iliya, Ibrahim Abdullahi Archibong, Victor Bassey Lemuel, Ann Monima Keneth Iceland, Kasozi Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title | Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title_full | Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title_fullStr | Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title_full_unstemmed | Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title_short | Tamarindus Indica Ameliorates Behavioral and Cytoarchitectural Changes in the Cerebellar Cortex Following Prenatal Aluminum Chloride Exposure in Wistar Rats. |
| title_sort | tamarindus indica ameliorates behavioral and cytoarchitectural changes in the cerebellar cortex following prenatal aluminum chloride exposure in wistar rats |
| topic | Tamarindus Indica Glial Fibrillary Protein Motor Cordination Aluminum Exposure |
| url | http://hdl.handle.net/20.500.12493/932 |
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