Antiplasmodial Compounds from Millettia Dura.
Malaria still poses a big challenge to the health care of many tropical countries. The plasmodium resistance to the conventional drugs is the major hitch in its treatment. Higher plants have produced single line antimalarials and given important lead molecules. On this basis, flavonoids isolated fro...
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| Language: | en_US |
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Kabale University
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/930 |
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| author | Buyinza, Daniel Derese, Solomon Ndakala, Albert |
| author_facet | Buyinza, Daniel Derese, Solomon Ndakala, Albert |
| author_sort | Buyinza, Daniel |
| collection | KAB-DR |
| description | Malaria still poses a big challenge to the health care of many tropical countries. The plasmodium resistance to the conventional drugs is the major hitch in its treatment. Higher plants have produced single line antimalarials and given important lead molecules. On this basis, flavonoids isolated from millettia dura by chromatographic techniques were screened againest W2 and D6 strains of plasmoduim falcipalum. Both, the crude and pure compounds tested showed mild activities against the test organisms. The crude extract of the stem bark had the highest respective activity of 63.7±8.6 and 46.1±4.5 μg/ml against W2 and D6. Of the pure compounds, milletosin was active towards both W2 and D6 with a respective
IC50s of 87.9±8.9 and 66.70±30.3 μg/ml. Synergistic effect might have contributed to the relative high activity of the crude than the pure compounds. Basing on the structure activity relationship of the tested compounds, suitable structural modification could be ideal to enhance the antiplasmodial activity.
Keywords: Antiplasmodial, Compounds, Millettia Dura. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-930 |
| institution | KAB-DR |
| language | en_US |
| publishDate | 2023 |
| publisher | Kabale University |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9302024-01-17T04:44:05Z Antiplasmodial Compounds from Millettia Dura. Buyinza, Daniel Derese, Solomon Ndakala, Albert Antiplasmodial Compounds Millettia Dura Malaria still poses a big challenge to the health care of many tropical countries. The plasmodium resistance to the conventional drugs is the major hitch in its treatment. Higher plants have produced single line antimalarials and given important lead molecules. On this basis, flavonoids isolated from millettia dura by chromatographic techniques were screened againest W2 and D6 strains of plasmoduim falcipalum. Both, the crude and pure compounds tested showed mild activities against the test organisms. The crude extract of the stem bark had the highest respective activity of 63.7±8.6 and 46.1±4.5 μg/ml against W2 and D6. Of the pure compounds, milletosin was active towards both W2 and D6 with a respective IC50s of 87.9±8.9 and 66.70±30.3 μg/ml. Synergistic effect might have contributed to the relative high activity of the crude than the pure compounds. Basing on the structure activity relationship of the tested compounds, suitable structural modification could be ideal to enhance the antiplasmodial activity. Keywords: Antiplasmodial, Compounds, Millettia Dura. 2023-02-03T05:23:34Z 2023-02-03T05:23:34Z 2022 Article http://hdl.handle.net/20.500.12493/930 en_US application/pdf Kabale University |
| spellingShingle | Antiplasmodial Compounds Millettia Dura Buyinza, Daniel Derese, Solomon Ndakala, Albert Antiplasmodial Compounds from Millettia Dura. |
| title | Antiplasmodial Compounds from Millettia Dura. |
| title_full | Antiplasmodial Compounds from Millettia Dura. |
| title_fullStr | Antiplasmodial Compounds from Millettia Dura. |
| title_full_unstemmed | Antiplasmodial Compounds from Millettia Dura. |
| title_short | Antiplasmodial Compounds from Millettia Dura. |
| title_sort | antiplasmodial compounds from millettia dura |
| topic | Antiplasmodial Compounds Millettia Dura |
| url | http://hdl.handle.net/20.500.12493/930 |
| work_keys_str_mv | AT buyinzadaniel antiplasmodialcompoundsfrommillettiadura AT deresesolomon antiplasmodialcompoundsfrommillettiadura AT ndakalaalbert antiplasmodialcompoundsfrommillettiadura |