A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda
Background—misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among he...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI.
2023
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12493/929 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1800403071203803136 |
|---|---|
| author | Keneth Iceland, Kasozi Anne, Laudisoit Lawrence Obado, Osuwat Gaber El-Saber, Batiha Naif E. Al, Omairi Eric, Aigbogun Herbert Izo, Ninsiima Ibe Michael, Usman Lisa M., DeTora Ewan Thomas, MacLeod Halima, Nalugo Francis P., Crawley Barbara E., Bierer Daniel Chans, Mwandah Charles Drago, Kato Kenedy, Kiyimba Emmanuel Tiyo, Ayikobua Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius David Paul, Nalumenya Robinson, Ssebuufu Nina Olivia, Rugambwa Grace Henry, Musoke Kevin, Bardosh Juma John, Ochieng Fred, Ssempijja Patrick, Kyamanywa Gabriel, Tumwine Khalid J., Alzahrani Susan Christina, Welburn |
| author_facet | Keneth Iceland, Kasozi Anne, Laudisoit Lawrence Obado, Osuwat Gaber El-Saber, Batiha Naif E. Al, Omairi Eric, Aigbogun Herbert Izo, Ninsiima Ibe Michael, Usman Lisa M., DeTora Ewan Thomas, MacLeod Halima, Nalugo Francis P., Crawley Barbara E., Bierer Daniel Chans, Mwandah Charles Drago, Kato Kenedy, Kiyimba Emmanuel Tiyo, Ayikobua Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius David Paul, Nalumenya Robinson, Ssebuufu Nina Olivia, Rugambwa Grace Henry, Musoke Kevin, Bardosh Juma John, Ochieng Fred, Ssempijja Patrick, Kyamanywa Gabriel, Tumwine Khalid J., Alzahrani Susan Christina, Welburn |
| author_sort | Keneth Iceland, Kasozi |
| collection | KAB-DR |
| description | Background—misinformation and mistrust often undermines community vaccine uptake,
yet information in rural communities, especially of developing countries, is scarce. This study aimed
to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical
trials among healthcare workers and staff in Uganda. Methods—a rapid exploratory survey was
conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the
country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence,
and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda.
Results—we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being
more informed than females (OR = 1.5, 95% CI: 0.7–3.0), and mistrust associated with policy decisions
to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting
challenges for the upcoming Oxford–AstraZeneca vaccinations. Knowledge, confidence and trust
scores were higher among the least educated (certificate vs. bachelor degree holders). We also found
a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as
the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3)
currently being promoted by the Ugandan government raises major policy concerns. High fear and
mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and
more affluent regions of the country. Conclusion—our study found that knowledge, confidence,
and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those
with higher wealth and educational status. There is a need to increase transparency and inclusive
participation to address these issues before new trials of COVID-19 vaccines are initiated |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-929 |
| institution | KAB-DR |
| language | English |
| publishDate | 2023 |
| publisher | MDPI. |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9292024-01-17T04:44:29Z A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda Keneth Iceland, Kasozi Anne, Laudisoit Lawrence Obado, Osuwat Gaber El-Saber, Batiha Naif E. Al, Omairi Eric, Aigbogun Herbert Izo, Ninsiima Ibe Michael, Usman Lisa M., DeTora Ewan Thomas, MacLeod Halima, Nalugo Francis P., Crawley Barbara E., Bierer Daniel Chans, Mwandah Charles Drago, Kato Kenedy, Kiyimba Emmanuel Tiyo, Ayikobua Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius David Paul, Nalumenya Robinson, Ssebuufu Nina Olivia, Rugambwa Grace Henry, Musoke Kevin, Bardosh Juma John, Ochieng Fred, Ssempijja Patrick, Kyamanywa Gabriel, Tumwine Khalid J., Alzahrani Susan Christina, Welburn COVID-19 clinical trials in resource poor countries COVID-19 Clinical trials in Africa COVID-19 and medical workers; Vaccines COVAX Background—misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among healthcare workers and staff in Uganda. Methods—a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence, and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda. Results—we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being more informed than females (OR = 1.5, 95% CI: 0.7–3.0), and mistrust associated with policy decisions to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting challenges for the upcoming Oxford–AstraZeneca vaccinations. Knowledge, confidence and trust scores were higher among the least educated (certificate vs. bachelor degree holders). We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3) currently being promoted by the Ugandan government raises major policy concerns. High fear and mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and more affluent regions of the country. Conclusion—our study found that knowledge, confidence, and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those with higher wealth and educational status. There is a need to increase transparency and inclusive participation to address these issues before new trials of COVID-19 vaccines are initiated Kabale University 2023-02-02T05:56:53Z 2023-02-02T05:56:53Z 2021-03-12 Article Kasozi, K.I.; Laudisoit, A.; Osuwat, L.O.; Batiha, G.E.-S.; Al Omairi, N.E.; Aigbogun, E.; Ninsiima, H.I.; Usman, I.M.; DeTora, L.M.; MacLeod, E.T.; et al. A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda. Vaccines 2021, 9, 253. https://doi.org/10.3390/ vaccines9030253 http://hdl.handle.net/20.500.12493/929 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf MDPI. |
| spellingShingle | COVID-19 clinical trials in resource poor countries COVID-19 Clinical trials in Africa COVID-19 and medical workers; Vaccines COVAX Keneth Iceland, Kasozi Anne, Laudisoit Lawrence Obado, Osuwat Gaber El-Saber, Batiha Naif E. Al, Omairi Eric, Aigbogun Herbert Izo, Ninsiima Ibe Michael, Usman Lisa M., DeTora Ewan Thomas, MacLeod Halima, Nalugo Francis P., Crawley Barbara E., Bierer Daniel Chans, Mwandah Charles Drago, Kato Kenedy, Kiyimba Emmanuel Tiyo, Ayikobua Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius Linda, Lillian Kevin, Matama Shui Ching, Nelly Mak David, Onanyang Theophilus, Pius David Paul, Nalumenya Robinson, Ssebuufu Nina Olivia, Rugambwa Grace Henry, Musoke Kevin, Bardosh Juma John, Ochieng Fred, Ssempijja Patrick, Kyamanywa Gabriel, Tumwine Khalid J., Alzahrani Susan Christina, Welburn A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title | A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title_full | A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title_fullStr | A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title_full_unstemmed | A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title_short | A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda |
| title_sort | descriptive multivariate analysis of community knowledge confidence and trust in covid 19 clinical trials among healthcare workers in uganda |
| topic | COVID-19 clinical trials in resource poor countries COVID-19 Clinical trials in Africa COVID-19 and medical workers; Vaccines COVAX |
| url | http://hdl.handle.net/20.500.12493/929 |
| work_keys_str_mv | AT kenethicelandkasozi adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT annelaudisoit adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lawrenceobadoosuwat adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gaberelsaberbatiha adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT naifealomairi adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ericaigbogun adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT herbertizoninsiima adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ibemichaelusman adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lisamdetora adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ewanthomasmacleod adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT halimanalugo adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT francispcrawley adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT barbaraebierer adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT danielchansmwandah adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT charlesdragokato adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kenedykiyimba adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT emmanueltiyoayikobua adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lindalillian adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinmatama adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT shuichingnellymak adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidonanyang adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT theophiluspius adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lindalillian adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinmatama adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT shuichingnellymak adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidonanyang adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT theophiluspius adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidpaulnalumenya adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT robinsonssebuufu adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ninaoliviarugambwa adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gracehenrymusoke adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinbardosh adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT jumajohnochieng adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT fredssempijja adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT patrickkyamanywa adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gabrieltumwine adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT khalidjalzahrani adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT susanchristinawelburn adescriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kenethicelandkasozi descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT annelaudisoit descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lawrenceobadoosuwat descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gaberelsaberbatiha descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT naifealomairi descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ericaigbogun descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT herbertizoninsiima descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ibemichaelusman descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lisamdetora descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ewanthomasmacleod descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT halimanalugo descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT francispcrawley descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT barbaraebierer descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT danielchansmwandah descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT charlesdragokato descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kenedykiyimba descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT emmanueltiyoayikobua descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lindalillian descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinmatama descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT shuichingnellymak descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidonanyang descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT theophiluspius descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT lindalillian descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinmatama descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT shuichingnellymak descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidonanyang descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT theophiluspius descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT davidpaulnalumenya descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT robinsonssebuufu descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT ninaoliviarugambwa descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gracehenrymusoke descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT kevinbardosh descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT jumajohnochieng descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT fredssempijja descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT patrickkyamanywa descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT gabrieltumwine descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT khalidjalzahrani descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda AT susanchristinawelburn descriptivemultivariateanalysisofcommunityknowledgeconfidenceandtrustincovid19clinicaltrialsamonghealthcareworkersinuganda |