Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance
Background: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries. African animal trypanocide resistance (AATr) is rife in an environment where drug use and policy decisions ar...
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| Format: | Article |
| Language: | English |
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Tropical Medicine and Infectious Disease
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/928 |
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| author | Keneth Iceland, Kasozi Ewan Thomas, MacLeod Charles, Waiswa Michael, Mahero Ibrahim, Ntulume Susan Christina, Welburn |
| author_facet | Keneth Iceland, Kasozi Ewan Thomas, MacLeod Charles, Waiswa Michael, Mahero Ibrahim, Ntulume Susan Christina, Welburn |
| author_sort | Keneth Iceland, Kasozi |
| collection | KAB-DR |
| description | Background: African trypanocide resistance is an emerging public health emergency whose
control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries.
African animal trypanocide resistance (AATr) is rife in an environment where drug use and policy
decisions are disjointed. The objective of the study was to identify community factors responsible
for the development of AATr. This was important since diminazene aceturate (DA), isometamidium
chloride (ISM), and homidium bromide (HB) have existed for over 30 years and no new drugs have
been provided to farmers. Methods: An electronic keyword search across 12 databases was conducted
using a search criterion from 1806 to June 2022. This generated a total of 24 publications, but after
removing duplicates, review articles, and nonrelated articles, a total of eight papers were included in
the analysis by following the PRISMA checklist. A meta-analysis was conducted on the data extracted
and the risk ratio and inverse variance at 95% confidence interval were calculated using RevMan®.
Results: All the eight articles in the study showed that DA was the most preferred trypanocide in
both West and Eastern Africa. Poor farmer knowledge of AATr and limited drug options were major
drivers for trypanocide resistance. In addition, farmer treatments, use of untrained personnel, poor
administration, poor dosing, and preparation of trypanocides were major drivers for the development
of AATr and similarities were identified in DA and ISM practices (P = 0.13). Conclusions: AATr
is spread in developing countries due to a lack of community knowledge, attitudes, and drug-use
practices. This situation could be reversed through interdisciplinary collaborations in endemic
communities by promoting effective treatments and responsible drug handling. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-928 |
| institution | KAB-DR |
| language | English |
| publishDate | 2023 |
| publisher | Tropical Medicine and Infectious Disease |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9282024-01-17T04:44:00Z Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance Keneth Iceland, Kasozi Ewan Thomas, MacLeod Charles, Waiswa Michael, Mahero Ibrahim, Ntulume Susan Christina, Welburn Trypanocide resistance Trypanosomiasis Human African trypanosomiasis Animal African trypanosomiasis Global health One health Community practices attitudes and practices AATr Background: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries. African animal trypanocide resistance (AATr) is rife in an environment where drug use and policy decisions are disjointed. The objective of the study was to identify community factors responsible for the development of AATr. This was important since diminazene aceturate (DA), isometamidium chloride (ISM), and homidium bromide (HB) have existed for over 30 years and no new drugs have been provided to farmers. Methods: An electronic keyword search across 12 databases was conducted using a search criterion from 1806 to June 2022. This generated a total of 24 publications, but after removing duplicates, review articles, and nonrelated articles, a total of eight papers were included in the analysis by following the PRISMA checklist. A meta-analysis was conducted on the data extracted and the risk ratio and inverse variance at 95% confidence interval were calculated using RevMan®. Results: All the eight articles in the study showed that DA was the most preferred trypanocide in both West and Eastern Africa. Poor farmer knowledge of AATr and limited drug options were major drivers for trypanocide resistance. In addition, farmer treatments, use of untrained personnel, poor administration, poor dosing, and preparation of trypanocides were major drivers for the development of AATr and similarities were identified in DA and ISM practices (P = 0.13). Conclusions: AATr is spread in developing countries due to a lack of community knowledge, attitudes, and drug-use practices. This situation could be reversed through interdisciplinary collaborations in endemic communities by promoting effective treatments and responsible drug handling. Kabale University 2023-02-02T05:39:26Z 2023-02-02T05:39:26Z 2022-08-23 Article Kasozi, K.I.; MacLeod, E.T.; Waiswa, C.; Mahero, M.; Ntulume, I.; Welburn, S.C. Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance. Trop. Med. Infect. Dis. 2022, 7, 205. https://doi.org/10.3390/ tropicalmed7090205 http://hdl.handle.net/20.500.12493/928 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf Tropical Medicine and Infectious Disease |
| spellingShingle | Trypanocide resistance Trypanosomiasis Human African trypanosomiasis Animal African trypanosomiasis Global health One health Community practices attitudes and practices AATr Keneth Iceland, Kasozi Ewan Thomas, MacLeod Charles, Waiswa Michael, Mahero Ibrahim, Ntulume Susan Christina, Welburn Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title | Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title_full | Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title_fullStr | Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title_full_unstemmed | Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title_short | Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance |
| title_sort | systematic review and meta analysis on knowledge attitude and practices on african animal trypanocide resistance |
| topic | Trypanocide resistance Trypanosomiasis Human African trypanosomiasis Animal African trypanosomiasis Global health One health Community practices attitudes and practices AATr |
| url | http://hdl.handle.net/20.500.12493/928 |
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