The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections
Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. PCR remains the standard benchmark for initial diagnosis of COVID-19 infection, while advances in immunological profiling are guiding clinical treatment. The SARS- Cov-2 virus has underg...
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2023
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| Online Access: | http://hdl.handle.net/20.500.12493/924 |
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| author | Mohamed, Moubarak Keneth Iceland, Kasozi Helal F., Hetta Hazem M., Shaheen Abdur, Rauf Hayder M., Al-kuraishy Safaa, Qusti Eida M., Alshammari Emmanuel Tiyo, Ayikobua Fred, Ssempijja Adam Moyosore, Afodun Ritah, Kenganzi Ibe Michael, Usman Juma John, Ochieng Lawrence Obado, Osuwat Kevin, Matama Ali I., Al-Gareeb Emmanuel, Kairania Monica, Musenero Susan, Christina Welburn Gaber, El-Saber Batiha |
| author_facet | Mohamed, Moubarak Keneth Iceland, Kasozi Helal F., Hetta Hazem M., Shaheen Abdur, Rauf Hayder M., Al-kuraishy Safaa, Qusti Eida M., Alshammari Emmanuel Tiyo, Ayikobua Fred, Ssempijja Adam Moyosore, Afodun Ritah, Kenganzi Ibe Michael, Usman Juma John, Ochieng Lawrence Obado, Osuwat Kevin, Matama Ali I., Al-Gareeb Emmanuel, Kairania Monica, Musenero Susan, Christina Welburn Gaber, El-Saber Batiha |
| author_sort | Mohamed, Moubarak |
| collection | KAB-DR |
| description | Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov-
2 pandemic progresses. PCR remains the standard benchmark for initial diagnosis of COVID-19
infection, while advances in immunological profiling are guiding clinical treatment. The SARS-
Cov-2 virus has undergone multiple mutations since its emergence in 2019, resulting in changes in
virulence that have impacted on disease severity globally. The emergence of more virulent variants of
SARS-Cov-2 remains challenging for effective disease control during this pandemic. Major variants
identified to date include B.1.1.7, B.1.351; P.1; B.1.617.2; B.1.427; P.2; P.3; B.1.525; and C.37. Globally,
large unvaccinated populations increase the risk of more and more variants arising. With successive
waves of COVID-19 emerging, strategies that mitigate against community transmission need to be
implemented, including increased vaccination coverage. For treatment, convalescent plasma therapy,
successfully deployed during recent Ebola outbreaks and for H1N1 influenza, can increase survival rates and improve host responses to viral challenge. Convalescent plasma is rich with cytokines
(IL-1β, IL-2, IL-6, IL-17, and IL-8), CCL2, and TNFα, neutralizing antibodies, and clotting factors
essential for the management of SARS-CoV-2 infection. Clinical trials can inform and guide treatment
policy, leading to mainstream adoption of convalescent therapy. This review examines the limited
number of clinical trials published, to date that have deployed this therapy and explores clinical
trials in progress for the treatment of COVID-19 |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-924 |
| institution | KAB-DR |
| language | English |
| publishDate | 2023 |
| publisher | Life |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9242024-01-17T04:50:01Z The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections Mohamed, Moubarak Keneth Iceland, Kasozi Helal F., Hetta Hazem M., Shaheen Abdur, Rauf Hayder M., Al-kuraishy Safaa, Qusti Eida M., Alshammari Emmanuel Tiyo, Ayikobua Fred, Ssempijja Adam Moyosore, Afodun Ritah, Kenganzi Ibe Michael, Usman Juma John, Ochieng Lawrence Obado, Osuwat Kevin, Matama Ali I., Al-Gareeb Emmanuel, Kairania Monica, Musenero Susan, Christina Welburn Gaber, El-Saber Batiha coronavirus COVID-19 therapy COVID-19 vaccine COVID-19 convalescent therapy SARS-CoV-2 infection human antibodies variants of concern Ebola Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. PCR remains the standard benchmark for initial diagnosis of COVID-19 infection, while advances in immunological profiling are guiding clinical treatment. The SARS- Cov-2 virus has undergone multiple mutations since its emergence in 2019, resulting in changes in virulence that have impacted on disease severity globally. The emergence of more virulent variants of SARS-Cov-2 remains challenging for effective disease control during this pandemic. Major variants identified to date include B.1.1.7, B.1.351; P.1; B.1.617.2; B.1.427; P.2; P.3; B.1.525; and C.37. Globally, large unvaccinated populations increase the risk of more and more variants arising. With successive waves of COVID-19 emerging, strategies that mitigate against community transmission need to be implemented, including increased vaccination coverage. For treatment, convalescent plasma therapy, successfully deployed during recent Ebola outbreaks and for H1N1 influenza, can increase survival rates and improve host responses to viral challenge. Convalescent plasma is rich with cytokines (IL-1β, IL-2, IL-6, IL-17, and IL-8), CCL2, and TNFα, neutralizing antibodies, and clotting factors essential for the management of SARS-CoV-2 infection. Clinical trials can inform and guide treatment policy, leading to mainstream adoption of convalescent therapy. This review examines the limited number of clinical trials published, to date that have deployed this therapy and explores clinical trials in progress for the treatment of COVID-19 Kabale University 2023-02-02T04:36:49Z 2023-02-02T04:36:49Z 2021-07-31 Article Moubarak, M.; Kasozi, K.I.; Hetta, H.F.; Shaheen, H.M.; Rauf, A.; Al-kuraishy, H.M.; Qusti, S.; Alshammari, E.M.; Ayikobua, E.T.; Ssempijja, F.; et al. The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections. Life 2021, 11, 734. https://doi.org/ 10.3390/life11080734 http://hdl.handle.net/20.500.12493/924 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf Life |
| spellingShingle | coronavirus COVID-19 therapy COVID-19 vaccine COVID-19 convalescent therapy SARS-CoV-2 infection human antibodies variants of concern Ebola Mohamed, Moubarak Keneth Iceland, Kasozi Helal F., Hetta Hazem M., Shaheen Abdur, Rauf Hayder M., Al-kuraishy Safaa, Qusti Eida M., Alshammari Emmanuel Tiyo, Ayikobua Fred, Ssempijja Adam Moyosore, Afodun Ritah, Kenganzi Ibe Michael, Usman Juma John, Ochieng Lawrence Obado, Osuwat Kevin, Matama Ali I., Al-Gareeb Emmanuel, Kairania Monica, Musenero Susan, Christina Welburn Gaber, El-Saber Batiha The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title | The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title_full | The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title_fullStr | The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title_full_unstemmed | The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title_short | The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections |
| title_sort | rise of sars cov 2 variants and the role of convalescent plasma therapy for management of infections |
| topic | coronavirus COVID-19 therapy COVID-19 vaccine COVID-19 convalescent therapy SARS-CoV-2 infection human antibodies variants of concern Ebola |
| url | http://hdl.handle.net/20.500.12493/924 |
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