Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, ox...
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| Format: | Article |
| Language: | en_US |
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2023
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| Online Access: | http://hdl.handle.net/20.500.12493/906 |
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| author | Al-kuraishy, Hayder M. Al-Gareeb, Ali Ismail Mostafa-Hedeab, Gomaa Keneth Iceland, Kasozi Zirintunda, Gerald Aslam, Akhmed Allahyani, Mamdouh Welburn, Susan Christina Batiha, Gaber El-Saber |
| author_facet | Al-kuraishy, Hayder M. Al-Gareeb, Ali Ismail Mostafa-Hedeab, Gomaa Keneth Iceland, Kasozi Zirintunda, Gerald Aslam, Akhmed Allahyani, Mamdouh Welburn, Susan Christina Batiha, Gaber El-Saber |
| author_sort | Al-kuraishy, Hayder M. |
| collection | KAB-DR |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, oxidative stress, and sympatho-activation and in severe cases leads to sympathetic storm (SS). On the other
hand, an exaggerated immune response to the SARS-CoV-2 invasion may lead to
uncontrolled release of pro-inflammatory cytokine development of cytokine storm (CS).
In Covid-19, there are interactive interactions between CS and SS in the development of
multi-organ failure (MOF). Interestingly, cutting the bridge between CS and SS by antiinflammatory
and anti-adrenergic agents may mitigate complications that are induced by
SARS-CoV-2 infection in severely affected Covid-19 patients. The potential mechanisms
of SS in Covid-19 are through different pathways such as hypoxia, which activate the
central sympathetic center through carotid bodies chemosensory input and induced proinflammatory
cytokines, which cross the blood-brain barrier and activation of the sympathetic center. b2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation, and B-cells for the production of antibodies with inflammation exacerbation. b-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-kB. In conclusion, b-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. Evidence from this study triggers an idea for future prospective studies to confirm the potential role of b-blockers in the management of Covid-19. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-906 |
| institution | KAB-DR |
| language | en_US |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9062024-01-17T04:46:49Z Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. Al-kuraishy, Hayder M. Al-Gareeb, Ali Ismail Mostafa-Hedeab, Gomaa Keneth Iceland, Kasozi Zirintunda, Gerald Aslam, Akhmed Allahyani, Mamdouh Welburn, Susan Christina Batiha, Gaber El-Saber B-Blockers Sympathetic Cytokines Storms Covid-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, oxidative stress, and sympatho-activation and in severe cases leads to sympathetic storm (SS). On the other hand, an exaggerated immune response to the SARS-CoV-2 invasion may lead to uncontrolled release of pro-inflammatory cytokine development of cytokine storm (CS). In Covid-19, there are interactive interactions between CS and SS in the development of multi-organ failure (MOF). Interestingly, cutting the bridge between CS and SS by antiinflammatory and anti-adrenergic agents may mitigate complications that are induced by SARS-CoV-2 infection in severely affected Covid-19 patients. The potential mechanisms of SS in Covid-19 are through different pathways such as hypoxia, which activate the central sympathetic center through carotid bodies chemosensory input and induced proinflammatory cytokines, which cross the blood-brain barrier and activation of the sympathetic center. b2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation, and B-cells for the production of antibodies with inflammation exacerbation. b-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-kB. In conclusion, b-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. Evidence from this study triggers an idea for future prospective studies to confirm the potential role of b-blockers in the management of Covid-19. 2023-01-31T12:21:24Z 2023-01-31T12:21:24Z 2021 Article http://hdl.handle.net/20.500.12493/906 en_US application/pdf |
| spellingShingle | B-Blockers Sympathetic Cytokines Storms Covid-19 Al-kuraishy, Hayder M. Al-Gareeb, Ali Ismail Mostafa-Hedeab, Gomaa Keneth Iceland, Kasozi Zirintunda, Gerald Aslam, Akhmed Allahyani, Mamdouh Welburn, Susan Christina Batiha, Gaber El-Saber Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title | Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title_full | Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title_fullStr | Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title_full_unstemmed | Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title_short | Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. |
| title_sort | effects of b blockers on the sympathetic and cytokines storms in covid 19 |
| topic | B-Blockers Sympathetic Cytokines Storms Covid-19 |
| url | http://hdl.handle.net/20.500.12493/906 |
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