Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats.
Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer...
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Kabale University
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/905 |
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| author | Kalange, Muhamudu Nansunga, Miriam Keneth Iceland, Kasozi Kasolo, Josephine Namulema, Jackline Kasande Atusiimirwe, Jovile Tiyo Ayikobua, Emanuel Ssempijja, Fred Munanura, Edson Ireeta Matama, Kevin Semuyaba, Ibrahim Zirintunda, Gerald Gerald Okpanachi, Alfred Omachonu |
| author_facet | Kalange, Muhamudu Nansunga, Miriam Keneth Iceland, Kasozi Kasolo, Josephine Namulema, Jackline Kasande Atusiimirwe, Jovile Tiyo Ayikobua, Emanuel Ssempijja, Fred Munanura, Edson Ireeta Matama, Kevin Semuyaba, Ibrahim Zirintunda, Gerald Gerald Okpanachi, Alfred Omachonu |
| author_sort | Kalange, Muhamudu |
| collection | KAB-DR |
| description | Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate- Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). GroupV was the negative control consisting of healthy rats.
Results: Antimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing
that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries.
Keywords: Antimalarials, Pharmacodynamics, Antimalarial Agents, Malaria, Developing Countries, Gastric Ulcers. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-905 |
| institution | KAB-DR |
| publishDate | 2023 |
| publisher | Kabale University |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-9052024-01-17T04:43:43Z Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. Kalange, Muhamudu Nansunga, Miriam Keneth Iceland, Kasozi Kasolo, Josephine Namulema, Jackline Kasande Atusiimirwe, Jovile Tiyo Ayikobua, Emanuel Ssempijja, Fred Munanura, Edson Ireeta Matama, Kevin Semuyaba, Ibrahim Zirintunda, Gerald Gerald Okpanachi, Alfred Omachonu Antimalarials Pharmacodynamics Antimalarial Agents Malaria Developing Countries Gastric Ulcer Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate- Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). GroupV was the negative control consisting of healthy rats. Results: Antimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries. Keywords: Antimalarials, Pharmacodynamics, Antimalarial Agents, Malaria, Developing Countries, Gastric Ulcers. 2023-01-31T11:50:06Z 2023-01-31T11:50:06Z 2020 Article http://hdl.handle.net/20.500.12493/905 application/pdf Kabale University |
| spellingShingle | Antimalarials Pharmacodynamics Antimalarial Agents Malaria Developing Countries Gastric Ulcer Kalange, Muhamudu Nansunga, Miriam Keneth Iceland, Kasozi Kasolo, Josephine Namulema, Jackline Kasande Atusiimirwe, Jovile Tiyo Ayikobua, Emanuel Ssempijja, Fred Munanura, Edson Ireeta Matama, Kevin Semuyaba, Ibrahim Zirintunda, Gerald Gerald Okpanachi, Alfred Omachonu Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title | Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title_full | Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title_fullStr | Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title_full_unstemmed | Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title_short | Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. |
| title_sort | antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative oxidative enzymes in male wistar rats |
| topic | Antimalarials Pharmacodynamics Antimalarial Agents Malaria Developing Countries Gastric Ulcer |
| url | http://hdl.handle.net/20.500.12493/905 |
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